Results 211 to 220 of about 290,709 (248)

Expression of Vascular Endothelial Growth Factor C and Vascular Endothelial Growth Factor Receptor 3 in Corneal Lymphangiogenesis

Experimental Eye Research, 2001
Lymphangiogenesis has been reported in vascularized corneas. However, the molecular mechanisms of lymphangiogenesis in the cornea are still unclear. Since lymphatic vessels may contribute to a decreased success rate of keratoplasty in vascularized cornea by accelerating antigen recognition and graft rejection, elucidation of the mechanisms of corneal ...
T, Mimura, S, Amano, T, Usui, Y, Kaji, T, Oshika, Y, Ishii   +5 more
openaire   +2 more sources

Vascular endothelial growth factor-C and its receptor-3 signaling in tumorigenesis

3 Biotech, 2023
The cancer-promoting ligand vascular endothelial growth factor-C (VEGF-C) activates VEGF receptor-3 (VEGFR-3). The VEGF-C/VEGFR-3 axis is expressed by a range of human tumor cells in addition to lymphatic endothelial cells. Activating the VEGF-C/VEGFR-3 signaling enhances metastasis by promoting lymphangiogenesis and angiogenesis inside and around ...
Selvaraj Vimalraj, Krishnasamy Naidu Gopal Hariprabu, Mostafizur Rahaman, Periyasami Govindasami, Karthikeyan Perumal, Saravanan Sekaran, Dhanraj Ganapathy   +6 more
openaire   +2 more sources

Developmental expression of vascular endothelial growth factor receptor 3 and vascular endothelial growth factor C in forebrain

Neuroscience, 2015
Increased understanding of the neurovascular niche suggests that development of the central nervous system (CNS) and its vasculature is coordinated through shared regulatory factors. These include the vascular endothelial growth factor (VEGF) family, reported to promote neuroproliferation and neuroprotection in addition to angiogenesis via its ...
M C, Ward, A M, Cunningham
openaire   +2 more sources

Vascular endothelial growth factor receptor-3 expression in mycosis fungoides

Leukemia & Lymphoma, 2012
Here, we have studied vascular endothelial growth factor receptor-3 (VEGFR-3) expression in mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma (CTCL). Immunohistochemistry revealed that in two-thirds of 34 patients, VEGFR-3 was expressed in situ by both tumor and stromal cells irrespective of the disease stage.
Pedersen, Ida Holst, Willerslev-Olsen, Andreas, Vetter-Kauczok, Claudia, Krejsgaard, Thorbjørn, Lauenborg, Britt, Kopp, Katharina Luise, Geisler, Carsten, Bonefeld, Charlotte M, Zhang, Qian, Wasik, Mariusz A, Dabelsteen, Sally, Andersen, Anders Woetmann, Becker, Jurgen C, Odum, Niels   +13 more
openaire   +3 more sources

Vascular Endothelial Growth Factor Receptor-3 Mediates Induction of Corneal Alloimmunity

Ocular Immunology and Inflammation, 2004
There are no studies so far linking molecular regulation of lymphangiogenesis and induction of adaptive immunity. Here, we show that blockade of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling significantly suppresses corneal antigen-presenting (dendritic) cell trafficking to draining lymph nodes, induction of delayed-type ...
Lu, Chen, Pedram, Hamrah, Claus, Cursiefen, Qiang, Zhang, Bronislaw, Pytowski, J Wayne, Streilein, M Reza, Dana   +6 more
openaire   +2 more sources

Vascular Endothelial Growth Factor Receptor-3

1999
Cell-cell communication during vascular development and tumour angiogenesis seems to involve at least five endothelial cell-specific tyrosine kinase receptors belonging to two distinct subclasses: two receptors of the Tie family, and three vascular endothelial cell growth factor receptors, VEGFR-1, -2 and -3, originally named Fltl (Fms-like tyrosine ...
J, Taipale, T, Makinen, E, Arighi, E, Kukk, M, Karkkainen, K, Alitalo   +5 more
openaire   +2 more sources

Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck

Head & Neck, 2003
AbstractBackground and Methods.VEGF proteins and their receptors are involved in tumor vessel neoformation. The third VEGF receptor, VEGFR3 (flt‐4) is important during both blood vessel development and lymphatic vessel formation. Because HNSCC preferentially metastasizes to regional lymph nodes, we investigated the expression of VEGFR3 and its ligand ...
Csilla, Neuchrist, Bohan M, Erovic, Allesandra, Handisurya, Michael B, Fischer, Georg E, Steiner, David, Hollemann, Claudia, Gedlicka, A, Saaristo, Martin, Burian   +8 more
openaire   +2 more sources

Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma

Cancer, 2003
AbstractBACKGROUNDVascular endothelial growth factor C (VEGF‐C) plays an important role in lymphangiogenesis and activates VEGF receptor 3 (VEGFR‐3). By contrast, lymphatic spread is an important prognostic factor in patients with nonsmall cell lung carcinoma (NSCLC).
Mitsuyuki, Arinaga, Tsuyoshi, Noguchi, Shinsuke, Takeno, Masao, Chujo, Takashi, Miura, Yuzo, Uchida   +5 more
openaire   +2 more sources

Serum vascular endothelial growth factor receptor 3 as a potential biomarker in psoriasis

Experimental Dermatology, 2018
AbstractTo discover novel biomarkers of psoriasis, a target‐specific antibody array screening of serum samples from psoriasis patients was initially performed. The results revealed that vascular endothelial growth factor receptor 3 (VEGFR‐3) was significantly elevated in the sera of psoriasis patients, compared to healthy controls.
Xia Hong, Shan Jiang, Nancy Marmolejo, Ramya Vangipuram, Elmira Ramos‐Rojas, Yulin Yuan, Zuan‐Tao Lin, Yaxi Li, Jingyi Qiu, Yikun Xing, Christopher Haley, Stephen K. Tyring, Tianfu Wu   +12 more
openaire   +2 more sources

Expression of vascular endothelial growth factor receptor‐3 (VEGFR‐3) in human prostate

The Prostate, 2003
AbstractBACKGROUNDThe growth and dissemination of tumors has been associated with angiogenesis, which is regulated by a group of polypeptide factors including vascular endothelial growth factor‐C (VEGF‐C). VEGF‐C binds its receptor, vascular endothelial growth factor receptor‐3 (VEGFR‐3) to promote growth of tumor‐associated lymphatic vessels.METHODSIn
Rile, Li, Mamoun, Younes, Thomas M, Wheeler, Peter, Scardino, Makato, Ohori, Anna, Frolov, Gustavo, Ayala   +6 more
openaire   +2 more sources