Results 21 to 30 of about 290,709 (248)

Vascular Endothelial Growth Factor Receptor 3 Is Involved in Tumor Angiogenesis and Growth [PDF]

Cancer Research, 2007
Abstract Vascular endothelial growth factor receptor 3 (VEGFR-3) binds VEGF-C and VEGF-D and is essential for the development of the lymphatic vasculature. Experimental tumors that overexpress VEGFR-3 ligands induce lymphatic vessel sprouting and enlargement and show enhanced metastasis to regional lymph nodes and beyond, whereas a ...
Pirjo, Laakkonen, Marika, Waltari, Tanja, Holopainen, Takashi, Takahashi, Bronislaw, Pytowski, Philipp, Steiner, Daniel, Hicklin, Kris, Persaud, James R, Tonra, Larry, Witte, Kari, Alitalo   +10 more
openaire   +2 more sources

Clinical significance of vascular endothelial growth factor‐C and vascular endothelial growth factor receptor 3 in patients with T1 lung adenocarcinoma [PDF]

Cancer, 2005
AbstractBACKGROUNDVascular endothelial growth factor‐C (VEGF‐C) plays an important role in lymphangiogenesis and activates VEGF receptor‐3 (VEGFR‐3). Lymphatic spread is an important prognostic factor in patients with lung adenocarcinoma. The aim of the current study was to determine whether the expression of VEGF‐C and VEGFR‐3 correlates with ...
Hiroshi, Kojima, Noriharu, Shijubo, Gen, Yamada, Shingo, Ichimiya, Shosaku, Abe, Masaaki, Satoh, Noriyuki, Sato   +6 more
openaire   +2 more sources

Quantification of Circulating Vascular Endothelial Growth Factor Receptor-3–Positive Lymphatic/Vascular Endothelial Progenitor Cells [PDF]

Clinical Cancer Research, 2009
To the Editor: We read with interest the article by Bogos et al. ([1][1]), which showed that circulating lymphatic/vascular endothelial progenitor cells (LVEPC) are significantly increased in small cell lung cancer (SCLC) patients and correlate with clinical behavior.
Farace, Françoise, Taylor, Melissa B., Rößler, Jochen, Loriot, Yohann, Besse, B.   +4 more
openaire   +2 more sources

Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma

Oncology Letters, 2014
Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis.
OMOTO, ITARU, MATSUMOTO, MASATAKA, OKUMURA, HIROSHI, UCHIKADO, YASUTO, SETOYAMA, TETSURO, KITA, YOSHIAKI, OWAKI, TETSUHIRO, KIJIMA, YUKO, SHINCHI, HIROYUKI, ISHIGAMI, SUMIYA, UENO, SHINICHI, NATSUGOE, SHOJI   +11 more
openaire   +3 more sources

Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in ovarian epithelial tumors

Chinese Journal of Cancer Research, 2007
Objective To explore the role of vascular endothelial growth factor-C (VEGF-C) in the process of angiogenesis, lymphangiogenesis and lymphatic metastasis in epithelial ovarian tumors.
Xiao-yan Fu, Ming-xing Ding, Ning Zhang, Xing-qiu Lin, Ji-cheng Li   +4 more
openaire   +1 more source

Mutation in Vascular Endothelial Growth Factor-C, a Ligand for Vascular Endothelial Growth Factor Receptor-3, Is Associated With Autosomal Dominant Milroy-Like Primary Lymphedema [PDF]

Circulation Research, 2013
Rationale: Mutations in vascular endothelial growth factor (VEGF) receptor-3 ( VEGFR3 or FLT4) cause Milroy disease, an autosomal dominant condition that presents with congenital lymphedema.
Gordon, Kristiana, Schulte, Dörte, Brice, Glen, Simpson, Michael A., Roukens, M. Guy, Van Impel, Andreas, Connell, Fiona, Kalidas, Kamini, Jeffery, Steve, Mortimer, Peter S., Mansour, Sahar, Schulte-Merker, Stefan, Ostergaard, Pia   +12 more
openaire   +5 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source