Results 91 to 100 of about 840,839 (338)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

ORGAN SPECIFIC VASCULAR RESPONSE TO FIBROSIS AFFECTS BREAST CANCER METASTATIC ORGANOTROPISM [PDF]

, 2016
The solid tumor microenvironment, pre-metastatic niche, and fibrotic environment are known to have significant biochemical and biomechanical similarities to the fibrotic environment. All have significantly increased levels of factors such as TGFβ, HIF1α,
Fletcher, Eliot S, Fletcher, Eliot S
core   +1 more source

Vascular endothelial growth factor signaling in development and disease

Development, 2018
Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems.
Sinem Karaman, V. Leppänen, K. Alitalo
semanticscholar   +1 more source

Vascular endothelial growth factor C promotes survival of retinal vascular endothelial cells via vascular endothelial growth factor receptor-2 [PDF]

British Journal of Ophthalmology, 2006
To determine vascular endothelial growth factor C (VEGF-C) expression in retinal endothelial cells, its antiapoptotic potential and its putative role in diabetic retinopathy.Cultured retinal endothelial cells and pericytes were exposed to tumour necrosis factor (TNF)alpha and VEGF-C expression determined by reverse transcriptase-polymerase chain ...
Bojun, Zhao, Gill, Smith, Jun, Cai, Aihua, Ma, Mike, Boulton   +4 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The relationship between 1,25(OH)D levels and interleukin-32 and vascular endothelial growth factor levels in endometriosis cyst tissue: An original article

SAGE Open Medicine
Background: Endometriosis involves the presence of endometrial-like tissue outside the uterus, driven by inflammatory pathways including elevated interleukin-32 and vascular endothelial growth factor.
Mirza Ismail, Hanom Husni Syam, Mulyanusa Amarullah Ritonga, Anita Rachmawati, Wiryawan Permadi, Ruswana Anwar, Shofwal Widad   +6 more
doaj   +1 more source

c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype. [PDF]

PLoS ONE, 2013
The proto-oncogene c-Myc is vital for vascular development and promotes tumor angiogenesis, but the mechanisms by which it controls blood vessel growth remain unclear. In the present work we investigated the effects of c-Myc knockdown in endothelial cell
Victoria Florea, Nithya Bhagavatula, Gordana Simovic, Francisco Y Macedo, Ricardo A Fock, Claudia O Rodrigues   +5 more
doaj   +1 more source

Myosin IIA-mediated forces regulate multicellular integrity during vascular sprouting [PDF]

, 2019
Angiogenic sprouting is a critical process involved in vascular network formation within tissues. During sprouting, tip cells and ensuing stalk cells migrate collectively into the extracellular matrix while preserving cell-cell junctions, forming patent ...
Chen, Christopher S., Choi, Colin, Dong, Li, Eyckmans, Jeroen, Howes, Caroline, King, Jessica, Mirabella, Teodelinda, Oberai, Assad, Stapleton, Sarah, Yang, Jinling, Yoon, Christine   +10 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cardiotoxicity with vascular endothelial growth factor inhibitor therapy

npj Precision Oncology, 2018
Angiogenesis inhibitors targeting the vascular endothelial growth factor (VEGF) signaling pathway (VSP) have been important additions in the therapy of various cancers, especially renal cell carcinoma and colorectal cancer.
R. Touyz, J. Herrmann
semanticscholar   +1 more source