Results 131 to 140 of about 982,599 (398)
Inhibition of renal cell carcinoma angiogenesis and growth by antisense oligonucleotides targeting vascular endothelial growth factor [PDF]
Angiogenesis is critical for growth and metastatic spread of solid tumours. It is tightly controlled by specific regulatory factors. Vascular endothelial growth factor has been implicated as the key factor in tumour angiogenesis.
A Takahashi +61 more
core +2 more sources
, 2000 In order to grow beyond minimal size and to metastasize, tumors need to induce the growth of new blood vessels (angiogenesis). Whereas in normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors ...
Detmar, Michael
core +1 more source
International Brazilian Journal of Urology, 2010 Bladder cancer is a common and frequently lethal cancer. Natural history studies indicate two distinct clinical and molecular entities corresponding to invasive and non-muscle invasive disease.
Xiaoping Yang, Thomas W. Flaig
doaj +1 more source
Development of a Computationally Optimized Model of Cancer-induced Angiogenesis through Specialized Cellular Mechanics [PDF]
arXiv, 2016 Angiogenesis, the development of new vasculature, is a critical process in the growth of new tumors. Driven by a goal to understand this aspect of cancer proliferation, I develop a discrete computationally optimized mathematical model of angiogenesis that specializes in intercellular interactions.
arxiv
Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony [PDF]
, 2010 A model is proposed to study the process of hypoxia-induced angiogenesis in cancer cells. The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake. VEGF-A is dynamically controlled by the HIF-1alpha concentration. If not degraded, HIF-1alpha can bind to the subunit termed HIF-1beta and so
arxiv +1 more source
Journal of Biochemistry (Tokyo), 2013 Vascular endothelial growth factors (VEGFs) belong to the platelet-derived growth factor supergene family, and they play central roles in the regulation of angiogenesis and lymphangiogenesis.
M. Shibuya
semanticscholar +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
Deleted in Malignant Brain Tumors 1 is Present in the Vascular Extracellular Matrix and Promotes Angiogenesis [PDF]
, 2012 Objective— Deleted in malignant brain tumors 1 (DMBT1) belongs to the scavenger receptor cysteine-rich superfamily of proteins and is implicated in innate immunity, cell polarity, and differentiation.
Eble, Johannes A +8 more
core +1 more source
Vascular growth factors in hypertensive state pathogenesis
Кардиоваскулярная терапия и профилактика, 2005 Summarizing and analyzing the information on the role of neurotrophic and growth factors in vascular pathology, arterial hypertension (AH), and organ damage (OD) pathogenesis, enables us to set new targets for treatment strategy.
O. A. Gomazkov
doaj
Retinal and choroidal angiogenesis: a review of new targets
International Journal of Retina and Vitreous, 2017 Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for ...
Thiago Cabral +6 more
doaj +1 more source