Results 1 to 10 of about 200,039 (118)

The vascular endothelium as decision maker in lung injury [PDF]

Frontiers in Cell and Developmental Biology
The vascular endothelium is the largest organ in the human body, capable of performing a wide range of cellular signaling and synthetic functions. It is also subjected to considerable mechanical stress due to the shear forces generated by blood flow ...
Diana Klein
doaj   +2 more sources

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

Redox Biology, 2021
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used.
Sindy Giebe, Anja Hofmann, Melanie Brux, Frazer Lowe, Damien Breheny, Henning Morawietz, Coy Brunssen   +6 more
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Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the primary cause of cardiovascular disease, the leading contributor of morbidity and mortality worldwide.
Emily Punch, Justus Klein, Patrick Diaba‐Nuhoho, Henning Morawietz, Mahdi Garelnabi   +4 more
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The aging endothelium

Vascular Biology, 2021
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases.
Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, Jennifer R Gamble   +4 more
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Reproducibility and research integrity: the role of scientists and institutions

BMC Research Notes, 2021
Reproducibility and research integrity are essential tenets of every scientific study and discovery. They serve as proof that an established and documented work can be verified, repeated, and reproduced.
Patrick Diaba-Nuhoho, Michael Amponsah-Offeh   +1 more
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YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment

Cell Communication and Signaling, 2020
Background Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment.
Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas, Jennifer R. Gamble   +7 more
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Oxidative Stress, Antioxidants and Hypertension

Antioxidants, 2023
As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and
Michael Amponsah-Offeh, Patrick Diaba-Nuhoho, Stephan Speier, Henning Morawietz   +3 more
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ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Vascular endothelial cell (EC) alignment in the direction of flow is an adaptive response that protects against aortic diseases, such as atherosclerosis. The Rho GTPases are known to regulate this alignment.
Angelina J. Lay, Paul R. Coleman, Ann Formaz‐Preston, Ka Ka Ting, Ben Roediger, Wolfgang Weninger, Martin A. Schwartz, Mathew A. Vadas, Jennifer R. Gamble   +8 more
doaj   +1 more source

Cross-Talk of NADPH Oxidases and Inflammation in Obesity

Antioxidants, 2023
Obesity is a major risk factor for cardiovascular and metabolic diseases. Multiple experimental and clinical studies have shown increased oxidative stress and inflammation linked to obesity.
Henning Morawietz, Heike Brendel, Patrick Diaba-Nuhoho, Rusan Catar, Nikolaos Perakakis, Christian Wolfrum, Stefan R. Bornstein   +6 more
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The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b

Molecular Therapy: Nucleic Acids, 2016
The regulation of function of endothelial cell–cell junctions is fundamental in sustaining vascular integrity. The polycistronic microRNA (miR) complexes containing miR-23a-27a-24-2, and 23b-27b-24-1 are predicted to target the majority of major ...
Jia Li, Yang Zhao, Ying Lu, William Ritchie, Georges Grau, Mathew A Vadas, Jennifer R Gamble   +6 more
doaj   +1 more source