Results 31 to 40 of about 200,188 (263)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
THE SENSITIVITY OF VASCULAR ENDOTHELIUM AND ITS PREDICTORS IN PATIENTS WITH CARDIOVASCULAR PATHOLOGY
Кардиоваскулярная терапия и профилактика, 2014 Aim. To estimate the role of endogenous metabolic factors in formation of vascular endothelium reactivity in patients with different genesis cardiovascular regulation disorders.Materials and methods.
E. O. Andreeva +3 more
doaj +1 more source
The Cell Surface, 2023 Multiple blood-borne pathogens infecting mammals establish close interactions with the host vascular endothelium as part of their life cycles. In this work, we investigate differences in the interactions of three Trypanosoma species: T.
Sara Silva Pereira +4 more
doaj +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
, 2018 Over the last 40 years, research on the vascular endothelium has provided important clues for the understanding of vascular disease. This new knowledge is finding its way into clinical medicine. In this review we deal with some areas where significant advances in the prevention and treatment of cardiovascular research has been achieved and with some of
openaire +3 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
AntioxidantsEndothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism ...
Michael Adu-Gyamfi +12 more
doaj +1 more source
VASOMOTOR FUNCTION OF THE ENDOTHELIUM IN PATIENTS WITH CHRONIC KIDNEY DISEASE AND HYPERTENSION
Український Журнал Нефрології та Діалізу, 2017 Investigation of the functional state of the vascular endothelium contributes to the further study of the mechanisms of development and pharmacological correction, particularly in hypertensive patients with chronic kidney disease.
N. V. Demikhova +3 more
doaj +1 more source
Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice. [PDF]
PLoS ONE, 2016 Endothelial-mesenchymal transition (EndMT) drives endothelium to contribute to normal development and disease processes. Here, we report that EndMTs occur in the diabetic endothelium of Ins2Akita/wt mouse, and show that induction of sex determining ...
Pierre J Guihard +5 more
doaj +1 more source
Bioactive Materials, 2023 Native-like endothelium regeneration is a prerequisite for material-guided small-diameter vascular regeneration. In this study, a novel strategy is proposed to achieve phase-adjusted endothelial healing by step-wise modification of parallel-microgroove ...
Bingcheng Yi +5 more
doaj +1 more source