Results 61 to 70 of about 19,730 (240)

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

The effects that secondary parkinsonian syndromes have on health status

Journal of Education, Health and Sport
Introduction and aim of work: The parkinsonian syndrome is a component of Parkinson's disease. A thorough neurological examination can detect symptoms belonging to the parkinsonian syndrome.
Dawid Kościołek, Michał Urbaś, Jakub Misiak, Aleksandra Kościołek, Martyna Kępczyk, Oliwia Czekaj, Miłosz Ojdana, Kaja Surowiecka, Oliwia Kwaśniewska, Yehor Demianenko   +9 more
doaj   +1 more source

Parkinsonism in in the Yaroslavl region: clinico-epidemiological aspects and a working experience of a specialized center

Анналы клинической и экспериментальной неврологии, 2017
The objective: to explore clinico-epidemiological aspects ofparkinsonism in the Yaroslavl region. One thousand patientswere examined in the movement disorders outpatient clinics in20072010.
N. V. Pizova, M. A. Bykanova, E. V. Kurapin, A. Yu. Kоvalchuk   +3 more
doaj   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Demographic and Clinical Profile of Patients with Parkinsonism in Northwestern Nigeria

Nigerian Journal of Medicine
Introduction: Parkinsonism is a disorder characterised by bradykinesia, rigidity, tremors and postural or gait abnormality of many aetiologies with idiopathic Parkinson’s disease (PD) topping the list of causes.
Halimat Hassan Amin, Salisu Abdullahi Balarabe, Abdullahi Ibrahim Augie, Kenechukwu Celsus Eze, Ochiaga Olisa, Farouk Kabir Umar   +5 more
doaj   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Long‐Term Ambient Benzene Exposure and Brain Disorders Among Urban Adults: Effect Modification by Genetic Susceptibility and Potential Mediation by Plasma Proteins

Advanced Science, EarlyView.
Low‐level ambient benzene exposure is associated with increased risks of multiple brain disorders in urban adults. Genetic susceptibility modifies these associations, while plasma proteomics points to potential biological pathways linking benzene exposure to adverse brain health.
Jianhui Guo, Xia Zhong, Petros Koutrakis, Carolina L. Zilli Vieira, Feifei Si, Yaqi Wang, Xinyao Lian, Yi Fan, Zhaokun Wang, Shaodan Huang, Jing Li   +10 more
wiley   +1 more source

The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review

Frontiers in Neurology
BackgroundDopaminergic imaging has become a pivotal tool in the diagnosis of Parkinson's disease (PD) and related disorders. Its ability to assess presynaptic dopamine transporter function provides crucial insights for distinguishing PD from other ...
Elena Ardila Jurado, Lisa Zünd-Hofer, Florian Brugger, Nicolas Nicastro, Kailash P. Bhatia, Georg Kägi, Georg Kägi   +6 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source