Results 121 to 130 of about 3,154,071 (299)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

open access: yesFEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain   +11 more
wiley   +1 more source

Management of vascular diseases

open access: yes, 2014
This thesis is about management of vascular diseases divided into three parts including arterial,venous and lymphatic disorders mainly focusing on pharmacological treatments.általános orvosangolegységes ...
Ghalegolab Behbahani, Arman
core  

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Mid-level Deep Pattern Mining∗

open access: yes, 2015
Mid-level visual element discovery aims to find clusters of image patches that are both representative and discrimi-native. In this work, we study this problem from the prospec-tive of pattern mining while relying on the recently popular-ized ...
Anton Van Den Hengel   +7 more
core   +1 more source

Anatomy and Classification of Pelvic Trauma

open access: yesJournal of Endovascular Resuscitation and Trauma Management
Pelvic fracture is one of the most complex injuries in trauma treatment. Bleeding continues to be one of the primary causes of death from pelvic fracture, and the severity of bleeding is not necessarily correlated with the fracture pattern.
Jacopo Giuliani   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

PATTERN OF PERIPHERAL VASCULAR DISEASE IN TROOPS AND TROOP FAMILIES IN ARMED FORCES

open access: yesPakistan Armed Forces Medical Journal, 2018
Objective: To delineate pattern of peripheral vascular disease (PAD) (upper or lower limb vessels) among troops and their families in the Armed Forces. Study Design: Cross sectional descriptive study.
Afshan Fayyaz   +2 more
doaj   +4 more sources

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen   +11 more
wiley   +1 more source

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