Results 191 to 200 of about 41,153 (223)

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Significance of Peripheral Perfusion Changes During Remote Ischemic Conditioning in Critically Ill Patients. [PDF]

J Clin Med
Jaras M, Chaleckas E, Pranskuniene Z, Tamosuitis T, Pranskunas A.   +4 more
europepmc   +1 more source

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

A narrow therapeutic window of platelet P2Y₁₂ reactivity in high-risk Chinese percutaneous coronary intervention patients. [PDF]

PeerJ
Gong L, Liu Y, Li J, Tan S, Guo C, Wang Z, Song H, Kuang Y, Cao Y, Yang G.   +9 more
europepmc   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Toward Optimal Antiplatelet Therapy in Acute Ischemic Stroke: What Can We Learn from a Post Hoc Subgroup Analysis of the ACUTE-PRAS Study? [PDF]

J Atheroscler Thromb
Wakisaka Y, Ago T.
europepmc   +1 more source

Reversing the irreversible? A case of successful surgical repair in a late-presenting aortopulmonary window with severe pulmonary hypertension. [PDF]

Egypt Heart J
Mulawarman R, Ongko Joyo E, Aefiansyah Putra MA, Agita Sembiring A, Natalia Siagian S, Lilyasari O.   +5 more
europepmc   +1 more source

Carnosine-Enriched Chicken Meat Improves Microvascular Function and Anti-Inflammatory Phenotype in Patients with Chronic Coronary Syndrome. [PDF]

Nutrients
Uršić D, Kolobarić N, Drenjančević I, Mihaljević Z, Šušnjara P, Stupin A, Jukić I, Kibel A.   +7 more
europepmc   +1 more source

Comparison of Peripapillary and Submacular Choroidal Changes After Trabeculectomy and Phaco-Trabeculectomy in Open-Angle Glaucoma. [PDF]

Clin Ophthalmol
Eraydin B, Cakmak-Cengiz E, Arıtürk N.
europepmc   +1 more source

Microvascular Dysfunction in Patients with Prediabetes: Novel Methods Identify Impaired Microcirculation. [PDF]

Life (Basel)
Lamprou S, Evangelidis N, Koletsos N, Zografou I, Stoimeni A, Mintziori G, Gkolias V, Trakatelli CM, Savopoulos C, Doumas M, Triantafyllou A.   +10 more
europepmc   +1 more source