Results 221 to 230 of about 5,143,177 (255)

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Impact of exercise on cognitive efficiency in older adults with subjective memory complaints: a randomized clinical trial. [PDF]

Front Aging Neurosci
Silva GO, Clark M, Lautenschlager NT, Thomas HJ, Smith KJ, Maslen BA, Cox KL, Pestell CF, Ainslie PN, Carter HH, Naylor LH, Green DJ.   +11 more
europepmc   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Mechanisms regulating cerebral perfusion during running exercise: Influence of foot strike-induced pulsatility oscillations, CO₂ reactivity and BP. [PDF]

J Physiol
Simpson LL, Perkins DR, Howe CA, Bruce CD, Cornwell WK, Lawley JS.   +5 more
europepmc   +1 more source

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

Impact of antiplatelet therapy on erectile dysfunction following percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction. [PDF]

Front Med (Lausanne)
Choi J, Lee CU, Park HW, Kim JH, Lee YS, Ahn JH, Koh JS, Kang MG, Kim W, Tantry US, Gurbel PA, Hwang JY, Jeong YH.   +12 more
europepmc   +1 more source

Corticosterone binds α_1A-adrenoceptors with high affinity and induces strain-dependent vascular desensitization in female spontaneously hypertensive rats. [PDF]

Hypertens Res
Santander-Plantamura YA, Nuñez-Solano K, Sigrist-Flores SC, Gallardo-Ortíz IA, Hong E, Villalobos-Molina R.   +5 more
europepmc   +1 more source

Attenuation of short-term autonomic cardiovascular responses with advancing gestational age. [PDF]

Front Physiol
Moertl MG, Piani F, Lackner HK, Lučovnik M, Žebeljan I, Mahlmann A, Dinevski D.   +6 more
europepmc   +1 more source

Berry Anthocyanins and Their Metabolites in Endothelial Dysfunction Associated with Diabetes and Cardiometabolic Risk. [PDF]

Molecules
Zujko ME.
europepmc   +1 more source