Results 51 to 60 of about 41,153 (223)

Association between NT-pro-BNP levels and endothelial dysfunction assessed by digital thermal monitoring in patients with coronary artery disease

Frontiers in Cardiovascular Medicine
ObjectiveEndothelial dysfunction is a key mechanism in the progression of coronary artery disease (CAD). N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), a biomarker of myocardial wall stress, has been associated with vascular abnormalities beyond
Ji-Hung Wang, Ji-Hung Wang, Ji-Hung Wang, I-Min Su, I-Min Su, I-Min Su, Bang-Gee Hsu, Bang-Gee Hsu, Bang-Gee Hsu, Bang-Gee Hsu   +9 more
doaj   +1 more source

Diagnosing migraine with vasomotor reactivity using the migraine vascular index: a validation study

Romanian Journal of Neurology
Background. Migraine is diagnosed based on the International Headache Society (IHS) criteria, all of which are subjective complaints. Endothelial dysfunction and altered vasomotor reactivity have been implicated in migraine pathophysiology, which has been objectively studied as reduced breath-holding index (BHI) in migraineurs. We aimed to validate the
Salim Harris, Teguh A. S. Ranakusuma, Al Rasyid, Efta Yudiarsah, Cleopas Martin Rumende, Darto Satoto, Aldy S. Rambe, Melissa A. L. Witjaksono, Kevin M. Saputri   +8 more
openaire   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Neckties and Cerebrovascular Reactivity in Young Healthy Males: A Pilot Randomised Crossover Trial

Stroke Research and Treatment, 2011
Background. A necktie may elevate intracranial pressure through compression of venous return. We hypothesised that a tight necktie would deleteriously alter cerebrovascular reactivity. Materials and Methods.
Mark Rafferty, Terence J. Quinn, Jesse Dawson, Matthew Walters   +3 more
doaj   +1 more source

Ultrasonographic Changes in Brain Hemodynamics in Patients with Parkinson’s Disease and Risk Factors for Cerebrovascular Disease: A Pilot Study

Parkinson's Disease, 2021
Recent epidemiological studies have revealed a correlation between atypical features and worse functional outcomes in Parkinson’s disease (PD) patients with cerebrovascular disease (CVD).
Rodrigo Tavares Brisson, Rita de Cássia Leite Fernandes, Josevânia Fulgêncio de Lima Arruda, Liene Duarte Silva, Marco Antônio Sales Dantas de Lima, Ana Lucia Zuma Rosso   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

A novel vascular health index: Using data analytics and population health to facilitate mechanistic modeling of microvascular status

Frontiers in Physiology, 2022
The study of vascular function across conditions has been an intensive area of investigation for many years. While these efforts have revealed many factors contributing to vascular health, challenges remain for integrating results across research groups,
Nithin J. Menon, Brayden D. Halvorson, Gabrielle H. Alimorad, Jefferson C. Frisbee, Daniel J. Lizotte, Daniel J. Lizotte, Daniel J. Lizotte, Aaron D. Ward, Aaron D. Ward, Daniel Goldman, Paul D. Chantler, Stephanie J. Frisbee, Stephanie J. Frisbee, Stephanie J. Frisbee   +13 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source