Results 51 to 60 of about 40,074 (224)

Ultrasonographic Changes in Brain Hemodynamics in Patients with Parkinson’s Disease and Risk Factors for Cerebrovascular Disease: A Pilot Study

Parkinson's Disease, 2021
Recent epidemiological studies have revealed a correlation between atypical features and worse functional outcomes in Parkinson’s disease (PD) patients with cerebrovascular disease (CVD).
Rodrigo Tavares Brisson, Rita de Cássia Leite Fernandes, Josevânia Fulgêncio de Lima Arruda, Liene Duarte Silva, Marco Antônio Sales Dantas de Lima, Ana Lucia Zuma Rosso   +5 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Diagnosing migraine with vasomotor reactivity using the migraine vascular index: a validation study

Romanian Journal of Neurology
Background. Migraine is diagnosed based on the International Headache Society (IHS) criteria, all of which are subjective complaints. Endothelial dysfunction and altered vasomotor reactivity have been implicated in migraine pathophysiology, which has been objectively studied as reduced breath-holding index (BHI) in migraineurs. We aimed to validate the
Salim Harris, Teguh A. S. Ranakusuma, Al Rasyid, Efta Yudiarsah, Cleopas Martin Rumende, Darto Satoto, Aldy S. Rambe, Melissa A. L. Witjaksono, Kevin M. Saputri   +8 more
openaire   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study

Journal of Atherosclerosis and Thrombosis, 2012
High-sensitivity C-reactive protein (hs-CRP) identifies individuals at risk for cardiovascular disease (CVD) without an increased level of low-density lipoprotein cholesterol (LDL-C). The present study was performed to compare hs-CRP and LDL-C in association with the cardio-ankle vascular index (CAVI) in Japanese community dwellers considered to be at ...
Higashiyama, Aya, Wakabayashi, Ichiro, Kubota, Yoshimi, Adachi, Yoshiko, Hayashibe, Akiko, Nishimura, Kunihiro, Sugiyama, Daisuke, Kadota, Aya, Imano, Hironori, Miyamatsu, Naomi, Miyamoto, Yoshihiro, Okamura, Tomonori   +11 more
openaire   +3 more sources

The impact of obesity on the parameters of cardiovascular remodeling, cerebral blood flow and autonomic regulation of cardiac rhythm in hypertensive patients

Zaporožskij Medicinskij Žurnal, 2017
Objective. The aim of this study was to assess autonomic regulation disturbances, disorders of systemic, brain and intra-cardiac hemodynamics and to find out the features of vascular and cardiac remodeling in patients with arterial hypertension ...
V. V. Syvolap, O. V. Vizir-Tronova
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source