Results 61 to 70 of about 1,333,578 (308)

EGR1 Nuclear Condensates Promote Renal Cyst Development in Polycystic Kidney Disease

Exploration
Autosomal dominant polycystic kidney disease (ADPKD) is marked by aberrant cell proliferation driven by cAMP‐PKA and MAPK signaling pathways. EGR1, a transcription factor directly activated by the above two pathways, is critical in the over‐proliferation
Chaoqun Ren, Zhaoxu Wu, Min Li, Yaqin Du, Hong Zhou, Yazhu Quan, Mengyao Xiong, Yiming Wang, Zhiwei Qiu, Shuai Zhu, Xiaowei Li, Jinzhao He, Cai Gao, Hui Cai, Tingting Li, Baoxue Yang   +15 more
doaj   +1 more source

C1q/TNF‐related protein 4 mediates proliferation and migration of vascular smooth muscle cells during vascular remodelling

Clinical and Translational Medicine, 2023
Background Vascular remodelling is an essential pathophysiological state in many circulatory diseases. Abnormal vascular smooth muscle cell (VSMC) behaviour leads to neointimal formation and may eventually results in major adverse cardiovascular events ...
Jingying Liu, Xingbo Long, Hexin Li, Qiuxia Yan, Lu Wang, Ziyu Qin, Hong Zhang   +6 more
doaj   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Hemodynamic Mechanisms Regulating Inflammatory Vascular Remodeling [PDF]

, 2017
Hemodynamic forces are critical regulators of vascular health and disease. Shear stress, the frictional force of blood flowing over the endothelium, is a major hemodynamic input into vascular function. For example, inflammatory blood flow patterns induce
Givens, Chris
core   +1 more source

Pulmonary Vascular Remodeling in Pulmonary Hypertension

, 2023
Pulmonary vascular remodeling is the critical structural alteration and pathological feature in pulmonary hypertension (PH) and involves changes in the intima, media and adventitia.
Shuai Wang, Yawen Cao, Zhuangzhuang Jia, Xuan Zhang, Jingyuan Mao, Lin Wang, Shanshan Lin, Haifeng Yan, Zeyu Zhang, Xianliang Wang, Lin, Shanshan, Zhang, Xuan, Wang, Shuai, Yan, Haifeng, Jia, Zhuangzhuang, Zhang, Zeyu, Cao, Yawen, Wang, Lin, Wang, Xianliang, Mao, Jingyuan   +19 more
core   +1 more source

KIF13B Attenuates Sepsis-Induced Myocardial Dysfunction through the Stabilization of PLIN5

Research
Sepsis-induced cardiac dysfunction (SICD) is a major contributor to mortality in sepsis. Kinesin family member 13B (KIF13B) has been identified as a critical protective factor for metabolic disorder and cardiovascular disease; however, the role of KIF13B
Lianxin Zhang, Guolin Miao, Si Mei, Yufei Han, Yitong Xu, Wenxi Zhang, Jingxuan Chen, Kaikai Lu, Yinqi Zhao, Zihao Zhou, Jinxuan Chen, Jiabao Guo, Pingping Lai, Sin Man Lam, Guanghou Shui, Ling Zhang, Weiguang Zhang, Wei Huang, Yuhui Wang, Xunde Xian   +19 more
doaj   +1 more source

Vascular Remodeling in Transplant Vasculopathy [PDF]

Circulation Research, 2007
As therapeutic strategies to prevent acute rejection progressively improve, transplant vasculopathy (TV) constitutes the single most important limitation for long-term functioning of solid organ allografts. In TV, allograft arteries characteristically develop severe, diffuse intimal hyperplastic lesions that eventually compromise luminal flow and cause
Richard N, Mitchell, Peter, Libby
openaire   +2 more sources

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Roles of matrix metalloproteinases in flow-induced outward vascular remodeling

, 2009
Sustained hemodynamic stresses, especially high blood flow, result in flow-induced outward vascular remodeling. Our previous study showed that macrophage depletion reduced flow-induced outward remodeling of the rat common carotid artery, indicating that ...
Hashimoto, Tomoki, Tsou, Tsung-Ling, Chang, Mayland, Mobashery, Shahriar, Ota, Ryo, Yeghiazarians, Yerem, Young, William L, Kurihara, Chie, Sakamoto, Atsuhiro   +8 more
core   +1 more source

Reduction of specific enterocytes from loss of intestinal LGR4 improves lipid metabolism in mice

Nature Communications
Whether intestinal Leucine-rich repeat containing G-protein-coupled receptor 4 (LGR4) impacts nutrition absorption and energy homeostasis remains unknown.
Yuan Liang, Chao Luo, Lijun Sun, Tiange Feng, Wenzhen Yin, Yunhua Zhang, Michael W. Mulholland, Weizhen Zhang, Yue Yin   +8 more
doaj   +1 more source