Results 51 to 60 of about 1,333,578 (308)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension. [PDF]

, 2013
BACKGROUND: Increased thoracic ascending aortic stiffness is thought to contribute to concentric left ventricular hypertrophy and increased mortality, a pattern seen in hypertension.
Francis, JM, Rider, OJ, Nethononda, R, Petersen, SE, Neubauer, Stefan, Francis, Jane M., Rider, Oliver J., Petersen, Steffen E., Neubauer, S, Nethononda, Richard, Clarke, Kieran, Byrne, James, Clarke, K, Byrne, JP, Leeson, P, Leeson, Paul   +15 more
core   +1 more source

Comprehensive annotation and analysis of human microproteins by human microprotein atlas platform

Communications Chemistry
Small open reading frames (sORFs) and their encoded microproteins are increasingly recognized as a widespread but poorly characterized components of the human proteome. Here we show a Human Microprotein Atlas (HMPA) platform that integrates 617,462 human
Boming Kang, Rui Fan, Xiangwen Ji, Yuan Zhou, Qinghua Cui, Chunmei Cui   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Annexin A5 Therapy Attenuates Vascular Inflammation and Remodeling and Improves Endothelial Function in Mice

, 2011
Objective— Annexin A5 (AnxA5) has antithrombotic, antiapoptotic, and antiinflammatory properties; we investigated its effectiveness against vascular inflammation, remodeling, and dysfunction in accelerated atherosclerosis.
Hetty C. de Boer, Paul H.A. Quax, Margreet R. de Vries, Mariette Nordzell, Johan Frostegård, Anton Jan van Zonneveld, J. Wouter Jukema, Mark M. Ewing, Knut Pettersson, Jukema, J.W., Nordzell, M., Pettersson, K., Quax, P.H.A., Zonneveld, A.J. van, Pettersson, K, Frostegard, J., Vries, M.R. de, Ewing, MM, Frostegard, J, Boer, H.C. de, de, Boer HC, Nordzell, M, van, Zonneveld AJ, Quax, PHA, de, Vries MR, Jukema, JW, Ewing, M.M.   +26 more
core   +1 more source

Intestinal Epithelial-Derived Exosomes Under Cold Stimulation Promote Adipose Thermogenesis

Metabolites
Background: Whether intestinal epithelial cells can regulate distant adipose tissue remains a mystery. Methods: Cold-stimulated intestinal epithelial cell-derived exosomes (Cold IEC-Exo) play a pivotal role in enhancing adipose thermogenesis and ...
Xue Han, Tiange Feng, Yaxu Yang, Ziming Zhu, Fangyu Shao, Lijun Sun, Yue Yin, Weizhen Zhang   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

ACSL1 Aggravates Thromboinflammation by LPC/LPA Metabolic Axis in Hyperlipidemia Associated Myocardial Ischemia‐Reperfusion Injury

Advanced Science
Acute myocardial infarction (AMI) is associated with well‐established metabolic risk factors, especially hyperlipidemia and obesity. Myocardial ischemia‐reperfusion injury (mIRI) significantly offsets the therapeutic efficacy of revascularization ...
Shuai Jiang, Xueguang Lin, Bo Chen, Gang Chen, Kristine J.S. Kwan, Jing Liu, Qi Sun, Jie Wang, Yijie Lu, Jindong Tong, Ying Deng, Bo Yu, Jingdong Tang   +12 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Disruption of Notch1 induces vascular remodeling, intussusceptive angiogenesis, and angiosarcomas in livers of mice [PDF]

, 2012
Notch signaling mediates embryonic vascular development and normal vascular remodeling; Notch1 knockout mice develop nodular regenerative hyperplasia (NRH).
Markus H. Heim, Tornillo, Luigi, Radtke, Freddy, Freddy Radtke, Rothweiler, Sonja, Rothweiler, S., Terracciano, L., Meili-Butz, S., Djonov, Valentin, Luigi Terracciano, Silvia Meili–Butz, Tornillo, L., Meili-Butz, Silvia, Dill, M. T., Djonov, V., Luigi Tornillo, Ruslan Hlushchuk, Radtke, F., Hlushchuk, R., Semela, D., Valentin Djonov, Dill, Michael T., Heim, M. H., Dill, Michael T, David Semela, Michael T. Dill, Sonja Rothweiler, Semela, David, Terracciano, Luigi, Hlushchuk, Ruslan, Heim, Markus H., Heim, Markus H, Djonov, Valentin Georgiev, Radtke F, Heim MH, Rothweiler S, Tornillo L, Meili-Butz S, Djonov V, Terracciano L, Hlushchuk R, Dill MT, Semela D   +42 more
core   +1 more source