Results 31 to 40 of about 1,333,578 (308)

TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding [PDF]

, 2019
Excessive vascular remodeling is characteristic of hemophilic arthropathy (HA) and may contribute to joint bleeding and the progression of HA. Mechanisms for pathological vascular remodeling after hemophilic joint bleeding are unknown.
von Drygalski, Annette, Wyseure, Tine, Wanko, Bettina, Olmer, Merissa, Mosnier, Laurent O., Behrendt, Niels, Zhou, Jenny Y., Morodomi, Yosuke, Morser, John, Lotz, Martin, Agashe, Ruchi, Cooke, Esther J., Yang, Tingyi, Laurent O. Mosnier, John Morser, Tine Wyseure, Bettina Wanko, Niels Behrendt, Esther J. Cooke, Ruchi Agashe, Jenny Y. Zhou, Martin Lotz, Yosuke Morodomi, Annette von Drygalski, Merissa Olmer, Tingyi Yang   +25 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Complement activation in vascular remodeling and organ damage

, 2008
Vascular remodeling is an active process of alterations as part of structural adaptations in response to injuries. In the process of remodeling, vessel wall cells can not only secrete complement components, but also represent potential targets of active ...
Zernecke, A., Shagdarsuren, E., Mueller, D.N., Weber, C., Erdenechimeg Shagdarsuren, Dominik Müller, Alma Zernecke, Christian Weber   +7 more
core   +1 more source

Triglyceride–glucose index in the associations between chronic low-grade inflammation and carotid intima-media thickness: mediation and effect-modification across triglyceride–glucose strata

BMC Cardiovascular Disorders
Aims Atherosclerosis is established as a chronic inflammatory disease, yet the potential mediating role of glucose and lipid metabolism in inflammation-driven atherogenesis has not been fully elucidated.
Xueguang Lin, Shishuai Xie, Bingbing Pu, Zheyu Wang, Hui Zhang, Yunxia Li, Jingdong Tang, Bo Yu, Shuai Jiang   +8 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Efficacy of various extent of resection on survival rates of patients with pilocytic astrocytoma: based on a large population

Scientific Reports
Pilocytic astrocytoma (PA) is classified as a Grade I benign neuroglial tumor. The extent of surgical resection is a critical factor influencing the prognosis for patients with PA.
Jun Su, Shanshan Guo, Zheyuan Chen, Yiming Han, Jingwang Yan, Qiyun Tang, Yu Mao, Haiqiang Zhang, Guojiang Hou, Gaopan Dong, Chao Guo, Pengfei Yang   +11 more
doaj   +1 more source

Citronellal Attenuates Oxidative Stress–Induced Mitochondrial Damage through TRPM2/NHE1 Pathway and Effectively Inhibits Endothelial Dysfunction in Type 2 Diabetes Mellitus

Antioxidants, 2022
In type 2 diabetes mellitus (T2DM), oxidative stress induces endothelial dysfunction (ED), which is closely related to the formation of atherosclerosis. However, there are few effective drugs to prevent and cure it. Citronellal (CT) is an aromatic active
Ya-Ling Yin, Huan-Huan Wang, Zi-Chen Gui, Shan Mi, Shuang Guo, Yue Wang, Qian-Qian Wang, Rui-Zhu Yue, Lai-Biao Lin, Jia-Xin Fan, Xue Zhang, Bing-Yan Mao, Tian-Heng Liu, Guang-Rui Wan, He-Qin Zhan, Mo-Li Zhu, Lin-Hua Jiang, Peng Li   +17 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Mechanobiology in vascular remodeling

, 2017
Vascular remodeling is a common pathological process in cardiovascular diseases and includes changes in cell proliferation, apoptosis and differentiation as well as vascular homeostasis.
Qing-Ping Yao, Kai Huang, Zong-Lai Jiang, Yue Han   +3 more
core   +1 more source