Results 21 to 30 of about 1,333,578 (308)

Airway wall remodeling in asthma : novel mechanisms of human bronchial smooth muscle cells in the induction of angiogenesis [PDF]

, 2014
Asthma is a global major health concern and it affects estimated 300 million people. The prevalence of asthma is rising and there is no cure for asthma, only the symptoms can be controlled.
Keglowich, Laura Franziska
core   +1 more source

Vascular Repair and Remodeling: A Review [PDF]

, 2017
Cardiovascular diseases (CVDs) such as ischemic heart disease (IHD), stroke, and peripheral artery disease (PAS) are the leading cause of mortality and morbidity around the world: about 30% of global deaths and 10% of global disease burden a year are due
Rodrigo Garcia, Jesica Ramirez, Ramírez, Jésica, Nicolas F. Renna, Roberto M. Miatello, Miatello, Roberto Miguel, García, Rodrigo Damián, Renna, Nicolas Federico   +7 more
core   +1 more source

Erythropoietin attenuates pulmonary vascular remodeling in experimental pulmonary arterial hypertension through interplay between endothelial progenitor cells and heme-oxygenase [PDF]

, 2015
BackgroundPulmonary arterial hypertension (PAH) is a pulmonary vascular disease with a high mortality, characterized by typical angio-proliferative lesions. Erythropoietin (EPO) attenuates pulmonary vascular remodeling in PAH. We postulated that EPO acts
Beatrijs eBartelds, Rolf M. F. Berger, Janny eTakens, Hans eWijnberg, Janny Takens, Berger, Rolf M F, Saffloer eMohaupt, Frank A.D.T.G. Wagener, Bartelds, Beatrijs, Frank A. D. T. G. Wagener, Pennings, Sebastiaan W C, Affara, Nada, Rosa L.E. Loon, Saffloer Mohaupt, Berger, Rolf M F; id_orcid, Nada eAffara, van Loon, Rosa Laura E, Sebastiaan W. C. Pennings, Wijnberg, Hans, Nada Affara, Wagener, Frank A D T G, Beatrijs Bartelds, Sebastiaan W.C. Pennings, Rosa Laura E. van Loon, Mohaupt, Saffloer, Takens, Janny, Rolf M.F. Berger, Hans Wijnberg   +27 more
core   +2 more sources

From remodeling to quiescence: The transformation of the vascular network

, 2021
The vascular system is essential for embryogenesis, healing, and homeostasis. Dysfunction or deregulated blood vessel function contributes to multiple diseases, including diabetic retinopathy, cancer, hypertension, or vascular malformations.
Franco Claudio Areias, Ouarné Marie, Pena Andreia, Andreia Pena, Marie Ouarné, Cláudio Areias Franco   +5 more
core   +1 more source

Intussusceptive Vascular Remodeling Precedes Pathological Neovascularization [PDF]

, 2019
Objective— Pathological neovascularization is crucial for progression and morbidity of serious diseases such as cancer, diabetic retinopathy, and age-related macular degeneration.
Marass, Michele,, del Peso, Luis,, Sandberg, Rickard,, Ntzouni, M., Schraermeyer, Ulrich,, Gerri, C., Anton Lennikov, Steffensen, John F, Mammadzada, Parviz, Lennikov, A., Lasse Dahl Jensen, Mammadzada, P., Neil Lagali, Peebo, B., Qiaolin Deng, Giatrellis, Sarantis, Cao, Renhai,, Kele, Julianna,, Mukwaya, Anthony, del Peso, L., Sandberg, R., Kele, J., Cao, R., Andre, Helder,, Peebo, Beatrice, Beatrice Peebo, Lagali, Neil,, Rickard Sandberg, Parviz Mammadzada, Michele Marass, Steffensen, John F.,, Cao, Yihai,, Mukwaya, Anthonny,, Cao, Y., Lennikov, Anton,, Renhai Cao, del Peso, Luis, Anthony Mukwaya, Mukwaya, Anthonny, Ramskold, Daniel,, Hildesjö, Camilla,, Peebo, Beatrice,, Kele, Julianna, Sandberg, Rickard, Ntzouni, Maria, Luis del Peso, Julianna Kele, Ulrich Schraermeyer, Dahl Jensen, L., Ramskold, D., Deng, Qiaolin,, Steffensen, J., Taylor, Michael, Deng, Q., Claudia Gerri, Ramskold, Daniel, Ali, Zaheer, Cao, Yihai, Ali, Zaheer,, Dahl Jensen, Lasse, Ali, Z., Giatrellis, S., Ntzouni, Maria,, Biesemeier, Antje,, Giatrellis, Sarantis,, Lennikov, Anton, Jensen, Lasse,, Marass, Michele, Antje Biesemeier, Gerri, Claudia, Peso, Luis del, Anders Kvanta, Jensen, Lasse, Zaheer Ali, Kvanta, Anders,, Deng, Qiaolin, John F. Steffensen, Gerri, Claudia,, Mukwaya, A., Andre, H., Lagali, N., Schraermeyer, Ulrich, Biesemeier, Antje, Daniel Ramsköld, Camilla Hildesjö, Jensen, Lasse Dahl, Kvanta, A., Steffensen, John F., Hildesjö, Camilla, Lagali, Neil, Marass, M., Taylor, Michael,, Biesemeier, A., Hildesjo, C., Cao, Renhai, Andre, Helder, Taylor, M., Kvanta, Anders, Helder Andre, Maria Ntzouni, Sarantis Giatrellis, Schraermeyer, U., Michael Taylor, Mammadzada, Parviz,, Yihai Cao, Mammadzada, P,, Ali, Z, Ramskold, D, Mukwaya, A, Giatrellis, S,, Biesemeier, A, Marass, M, Ntzouni, M, Lennikov, A, Cao, R   +114 more
core   +1 more source

Pericytes and Lung Vascular Remodeling. [PDF]

Arterioscler Thromb Vasc Biol
Pericytes are mural cells that line capillaries throughout the brain, retina, lung, and other organs, where they support capillary homeostasis through direct contact and paracrine crosstalk with capillary endothelium. Despite being described more than a century ago, their contributions to health and vascular diseases remain unclear,
Moss ME, Smit MC, Klouda T, Zhao Z, Alves G, Kim Y, Baek SH, Li Y, Yuan K.   +8 more
europepmc   +3 more sources

ATP-dependent chromatosome remodeling [PDF]

, 2008
Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina, Becker, Peter B., Maier, Verena K.   +2 more
core   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source