Results 1 to 10 of about 298,261 (120)

Perillaldehyde improves cognitive function in vivo and in vitro by inhibiting neuronal damage via blocking TRPM2/NMDAR pathway

Chinese Medicine, 2021
Background Vascular cognitive dysfunction in patients with vascular dementia (VD) is a kind of severe cognitive dysfunction syndrome caused by cerebrovascular diseases.
Yue Qiu, Xian-jun Xue, Geng Liu, Miao-miao Shen, Chun-yan Chao, Jie Zhang, Ya-qi Guo, Qian-qian Niu, Ya-nan Yu, Yu-ting Song, Huan-huan Wang, Shuang-xi Wang, Yu-jing Chen, Lin-hua Jiang, Peng Li, Ya-ling Yin   +15 more
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Puerarin Alleviates Vascular Cognitive Impairment in Vascular Dementia Rats

Frontiers in Behavioral Neuroscience, 2021
Cerebral ischemia triggers vascular dementia (VD), which is characterized by memory loss, cognitive deficits, and vascular injury in the brain. Puerarin (Pur) represents the major isoflavone glycoside of Radix Puerariae, with verified neuroprotective ...
Tiantian Zhu, Tiantian Zhu, Tiantian Zhu, Moli Zhu, Moli Zhu, Moli Zhu, Yue Qiu, Yue Qiu, Yue Qiu, Zeqing Wu, Zeqing Wu, Zeqing Wu, Ning Huang, Ning Huang, Ning Huang, Guangrui Wan, Guangrui Wan, Guangrui Wan, Jian Xu, Jian Xu, Jian Xu, Ping Song, Ping Song, Ping Song, Shuangxi Wang, Shuangxi Wang, Shuangxi Wang, Yaling Yin, Yaling Yin, Yaling Yin, Peng Li, Peng Li, Peng Li   +32 more
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Endothelial discoidin domain receptor 1 senses flow to modulate YAP activation

Nature Communications, 2023
Mechanotransduction in endothelial cells is critical to maintain vascular homeostasis and can contribute to disease development, yet the molecules responsible for sensing flow remain largely unknown.
Jiayu Liu, Chuanrong Zhao, Xue Xiao, Aohan Li, Yueqi Liu, Jianan Zhao, Linwei Fan, Zhenhui Liang, Wei Pang, Weijuan Yao, Wei Li, Jing Zhou   +11 more
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Hypoxia inducible factor-1α is an important regulator of macrophage biology

Heliyon, 2023
Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate
Bingquan Qiu, Piaoliu Yuan, Xiaojuan Du, Hongfang Jin, Junbao Du, Yaqian Huang   +5 more
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aFGF Targeted Mediated by Novel Nanoparticles-Microbubble Complex Combined With Ultrasound-Targeted Microbubble Destruction attenuates Doxorubicin-Induced Heart Failure via Anti-Apoptosis and Promoting Cardiac Angiogenesis

Frontiers in Pharmacology, 2021
The purpose of this study was to evaluate the protective effect of acidic fibroblast growth factor targeted mediated by novel nanoparticles–cationic lipid microbubbles complex (aFGF–NP + CPMBs) combined with ultrasound targeted microbubble destruction ...
Nan-Qian Zhou, Nan-Qian Zhou, Nan-Qian Zhou, Zhi-Xin Fang, Zhi-Xin Fang, Zhi-Xin Fang, Ning Huang, Ning Huang, Ning Huang, Yue Zuo, Yue Qiu, Yue Qiu, Yue Qiu, Li-Juan Guo, Ping Song, Ping Song, Ping Song, Jian Xu, Jian Xu, Jian Xu, Guang-rui Wan, Guang-rui Wan, Guang-rui Wan, Xin-Qiao Tian, Ya-ling Yin, Peng Li, Peng Li, Peng Li   +27 more
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Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Nonalcoholic Steatohepatitis and Atherosclerosis in LDLR-/- Hamsters

Research
Combined hyperlipidemia (CHL) manifests as elevated cholesterol and triglycerides, associated with fatty liver and cardiovascular diseases. Emerging evidence underscores the crucial role of the intestinal microbiota in metabolic disorders.
Guolin Miao, Jiabao Guo, Wenxi Zhang, Pingping Lai, Yitong Xu, Jingxuan Chen, Lianxin Zhang, Zihao Zhou, Yufei Han, Gonglie Chen, Jinxuan Chen, Yijun Tao, Lemin Zheng, Ling Zhang, Wei Huang, Yuhui Wang, Xunde Xian   +16 more
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The Buerger’s rabbit model: a closer step to unravelling thromboangiitis obliterans?

Thrombosis Journal
Objective Thromboangiitis obliterans (TAO) remains clinical challenging due to its rarity and underwhelming management outcomes. This study aimed to describe a novel TAO rabbit model that demonstrates a closer resemblance to TAO.
Jia-Long Li, Kristine J. S. Kwan, Xue-Guang Lin, Jie Wang, Bo Chen, Yi-Jie Lu, Bo Wang, Shi-Shuai Xie, Jiong Zhou, Bo Yu, Ying Deng, Shuai Jiang, Jing-Dong Tang   +12 more
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Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank

Scientific Reports
Phenotypic age acceleration (PhenoAgeAccel) is a novel biological indicator estimates an individual’s mortality risk. The primary aim of this study was to evaluate the association between PhenoAge and PhenoAgeAccel with incident cardiovascular diseases ...
Kristine J. S. Kwan, Shi-Shuai Xie, Hai-Lei Li, Xue-Guang Lin, Yi-Jie Lu, Bo Chen, Kai-Xin Ge, Shu-Ya Tang, Hui Zhang, Shuai Jiang, Jing-Dong Tang   +10 more
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SMARCB1 orchestrates cellular plasticity and oncogenic pathways in typical and chondroid chordomas

Scientific Reports
Chordomas are rare, aggressive tumors of the axial skeleton with limited treatment options. Genetic alterations in SMARCB1, a tumor suppressor gene, have been implicated in poorly differentiated chordomas, but their role in typical and chondroid subtypes
Weihai Liu, Moksada Regmi, Shikun Liu, Ying Xiong, Yuwei Dai, Yingjie Wang, Jun Yang, Chenlong Yang   +7 more
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Single-cell transcriptomic analysis identifies vascular smooth muscle cell transcriptional programs associated with human carotid plaque remodeling

Frontiers in Molecular Biosciences
BackgroundVascular smooth muscle cells (VSMCs) contribute to plaque structure and exhibit diverse transcriptional programs in human atherosclerosis. Although human plaque single-cell studies have established substantial VSMC heterogeneity, an important ...
Yi-Jie Lu, Yi-Jie Lu, Xue-Guang Lin, Ting Wang, Fan-Xuan Huang, Ying Deng, Ying Deng, Shuai Jiang, Jing Dong Tang, Bo Yu   +9 more
doaj   +1 more source