Results 31 to 40 of about 532,737 (293)

Haemodynamic changes during prone positioning in anaesthetised chronic cervical myelopathy patients

Indian Journal of Anaesthesia, 2019
Background and Aims: Anaesthetised patients, when positioned prone, experience hypotension and reduction in cardiac output. Associated autonomic dysfunction in cervical myelopathy patients predisposes them to haemodynamic changes.
Nitin Manohar, Venkatapura J Ramesh, Muthuchellappan Radhakrishnan, Dhritiman Chakraborti   +3 more
doaj   +1 more source

Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model

Cells, 2021
Background: Cardiovascular dysfunction is linked to insulin-resistant states. In this paper, we analyzed whether the severe hepatic insulin resistance of an inducible liver-specific insulin receptor knockout (iLIRKO) might generate vascular insulin ...
Almudena Gómez-Hernández, Natalia de las Heras, Andrea R. López-Pastor, Gema García-Gómez, Jorge Infante-Menéndez, Paula González-López, Tamara González-Illanes, Vicente Lahera, Manuel Benito, Óscar Escribano   +9 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Role of oxygenation and vascularization in drug resistance [PDF]

Cytotechnology, 1998
Oxygenation status and tumor vascularization seem to be important factors in determining therapeutic effectiveness and patient prognosis. An abundance of data on tumor oxygenation and vascularization is available and it clearly shows that most human solid tumors are heterogeneously oxygenated and vascularized. They contain hypoxic regions. Such regions
Manfred Volm, Jürgen Mattern
openaire   +3 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

FEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria, Cèlia Dobaño‐López, Patricia Pérez‐Galán, Christine Bezombes   +3 more
wiley   +1 more source

Effect of propofol on cerebral blood flow in patients with severe traumatic brain injury undergoing decompression craniectomy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Objective To analyze the effect of propofol on cerebral blood flow (CBF) in patients with severe traumatic brain injury (sTBI). Methods A total of 60 patients of sTBI undergoing unilateral decompression craniectomy in the Department of Neurosurgery from ...
Shao⁃bo REN, Li⁃hong LI
doaj  

Gangliosides Contribute to Vascular Insulin Resistance [PDF]

International Journal of Molecular Sciences, 2019
Insulin in physiological concentrations is important to maintain vascular function. Moreover, vascular insulin resistance contributes to vascular impairment. In the elderly, other factors including hypertension, dyslipidemia, and chronic inflammation amplify senescence of vascular endothelial and smooth muscle cells.
Norihiko Sasaki, Yoko Itakura, Masashi Toyoda   +2 more
openaire   +2 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Anxiety increases the blood pressure response during exercise

Motriz: Revista de Educacao Fisica, 2019
Aim: The hypothesis that higher levels of anxiety promote greater blood pressure (BP) responses during physical exercise is tested. The hypothesis that metaborreflex response is increased in an anxious individual is tested as well. Methods: There were
Diana de Medeiros Andrade, Josária Ferraz Amaral, Patrícia Fernandes Trevizan, Edgar Toschi-Dias, Lilian Pinto da Silva, Mateus Camaroti Laterza, Daniel Godoy Martinez   +6 more
doaj   +1 more source