Results 61 to 70 of about 795,255 (381)

Tradeoffs between energy efficiency and mechanical response in fluid flow networks [PDF]

arXiv, 2021
Transport networks are typically optimized, either by evolutionary pressures in biological systems or by human design in engineered structures. In the case of systems such as the animal vasculature, the transport of fluids is hindered by the inherent viscous resistance to flow while being kept in a dynamic state by the pulsatile nature of the heart and
arxiv  

Effective control of pulmonary vascular resistance with inhaled nitric oxide after cardiac operation [PDF]

, 1996
Increased pulmonary vascular resistance may greatly complicate the perioperative management of cardiac surgical patients. Inhaled nitric oxide may be a promising new therapy to selectively lower pulmonary vascular resistance.
Fullerton, David A., Grover, Frederick L., Jaggers, James, Jones, Stephen D., McIntyre, Robert C., Piedalue, Fran   +5 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

The influence of perfusion solution on renal graft viability assessment [PDF]

, 2012
BACKGROUND: Kidneys from donors after cardiac or circulatory death are exposed to extended periods of both warm ischemia and intra-arterial cooling before organ recovery.
CH Wilson, CH Wilson, D Shoskes, G Kootstra, JH Lee, JV Bonventre, JW Daemen, KJ Livak, MA Gok, MA Gok, MA Gok, MD Kay, MH Booster, MM El-Mas, MT Gravel, N Ahmad, N Ahmad, NR Brook, P Bell, RA Cowley, RT Currin, S Balupuri, SF Bronk, SR Johnson, TJ Wheatley, Y Lin, ZA Stewart   +26 more
core   +1 more source

Maternal haemodynamic function differs in pre‐eclampsia when it is associated with a small‐for‐gestational‐age newborn: a prospective cohort study [PDF]

, 2021
Objective To describe maternal haemodynamic differences in gestational hypertension with small‐for‐gestational‐age babies (HDP + SGA), gestational hypertension with appropriate‐for‐gestational‐age babies (HDP‐only) and control pregnancies.
Binder, J, Gutierrez, J, Khalil, A, Perry, H, Thilaganathan, B   +4 more
core   +1 more source

Gangliosides Contribute to Vascular Insulin Resistance [PDF]

International Journal of Molecular Sciences, 2019
Insulin in physiological concentrations is important to maintain vascular function. Moreover, vascular insulin resistance contributes to vascular impairment. In the elderly, other factors including hypertension, dyslipidemia, and chronic inflammation amplify senescence of vascular endothelial and smooth muscle cells.
Norihiko Sasaki, Yoko Itakura, Masashi Toyoda   +2 more
openaire   +2 more sources

Circulating tumor cells: advancing personalized therapy in small cell lung cancer patients

Molecular Oncology, EarlyView.
Small cell lung cancer (SCLC) is an aggressive form of lung cancer that spreads rapidly to secondary sites such as the brain and liver. Cancer cells circulating in the blood, “circulating tumor cells” (CTCs), have demonstrated prognostic value in SCLC, and evaluating biomarkers on CTCs could guide treatment decisions such as for PARP inhibitors ...
Prajwol Shrestha, Steven Kao, Veronica K. Cheung, Wendy A. Cooper, Nico van Zandwijk, John E. J. Rasko, Dannel Yeo   +6 more
wiley   +1 more source

The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment [PDF]

Elie Besserer-Offroy, et al. Pharmacol Res, Epub 9 March 2018, 2018
The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease.
arxiv   +1 more source

Pulmonary Hypertension in Elderly Patients with Diastolic Dysfunction and Preserved Ejection Fraction [PDF]

, 2013
: Purpose: Patients with diastolic dysfunction may have a disproportionate degree of elevation in pulmonary pressure, particularly in the elderly. Higher pulmonary vascular resistance in the elderly patients with heart failure but preserved ejection ...
Aragam JR, Bouchard JL, Bourge R, Capomolla S, Delgado JF, Enriquez-Sarano M, Fareed Collado, Fiack C, Gatzka CD, Grossman W, Hayward CS, Kelly R, Kessler KM, Khouri SJ, Kitzman DW, Lam C, Majid Afshar, Mitchell GF, Moraes DL, Neuman Y, Nishimura RA, Oh JK, Rami Doukky, Redfield MM, Redfield MM, Shapiro B, Shapiro V, Simonneau G, Smulyan H, Vaitkevicius PV, Willens HJ, Willens HJ   +31 more
core   +3 more sources

Genomic landscape and preclinical models of angiosarcoma

Molecular Oncology, EarlyView.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton, Bozhi Liu, Lauren E. Gartenhaus, Jason A. Hanna   +3 more
wiley   +1 more source