Results 61 to 70 of about 850,668 (354)

Central and peripheral pathogenetic forms of type 2 diabetes: a proof-of-concept study

Endocrine Connections, 2016
Hypothesis Previous studies provide evidence that glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) should not be considered as interchangeable alternatives in the diagnosis of the same type 2 diabetes, but as indicators of its different ...
Dmitry M Davydov, Malik K Nurbekov
doaj   +1 more source

Pulmonary arterial remodeling revealed by microfocal x-ray tomography [PDF]

, 2001
Animal models and micro-CT imaging are useful for understanding the functional consequences of, and identifying the genes involved in, the remodeling of vascular structures that accompanies pulmonary vascular disease.
Dawson, Christopher A, Dhyani, Anita H., Haworth, Steven Thomas, Karau, Kelly L., Molthen, Robert C.   +4 more
core   +1 more source

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Vascular nitric oxide resistance in type 2 diabetes

Cell Death and Disease, 2023
Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO• in both the macro- and microvessels, is a common state in type 2 diabetes (T2D) associated with developing cardiovascular events and death.
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi   +3 more
doaj   +1 more source

Yield Performance of Locally Selected Cocoa Clones in North Luwu [PDF]

, 2015
Participatory selection in North Luwu District selected some locally cocoa clones, of which MCC 01 and MCC 02 the most promising to be developed as clonal material.
Imran, I. (Imran), Sari, I. A. (Indah), Soesilo, A. W. (Agung)   +2 more
core   +3 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Perioperative challenges and outcome after surgical correction of post-myocardial infarction ventricular septal rupture: A retrospective single center study

Annals of Cardiac Anaesthesia
Background: Ventricular septal rupture (VSR) is a rare but grave complication of acute myocardial infarction (AMI). It is a mechanical complication of myocardial infarction where patients may present either in a compensated state or in cardiogenic shock.
Kedar Bangal
doaj   +1 more source

Adhering to a Tai Chi Chuan Exercise Program Improves Vascular Resistance and Cardiac Function

International Journal of Gerontology, 2011
Background: Cardiac function is an important predictor for life expectancy in elderly subjects. Tai Chi Chuan (TCC) is a generalized tolerable exercise for the aged population. The current study evaluated the effects of TCC on the vascular compliance and
Yin-Tsen Huang, Chun-Hsiung Wang, Yi-Fan Wu   +2 more
doaj   +1 more source

Improving guidance for the correctability of congenital cardiovascular shunts with increased pulmonary vascular resistance

International Journal of Cardiology Congenital Heart Disease, 2021
Background: Based upon expert opinion, guidelines have been proposed for the correctability of congenital cardiovascular shunts with increased pulmonary vascular resistance. This study reports the accuracy of published guidelines using a dataset from the
Ronald W. Day
doaj   +1 more source