Results 61 to 70 of about 4,471,992 (283)
Tradeoffs between energy efficiency and mechanical response in fluid flow networks [PDF]
arXiv, 2021 Transport networks are typically optimized, either by evolutionary pressures in biological systems or by human design in engineered structures. In the case of systems such as the animal vasculature, the transport of fluids is hindered by the inherent viscous resistance to flow while being kept in a dynamic state by the pulsatile nature of the heart and
arxiv
Gangliosides Contribute to Vascular Insulin Resistance [PDF]
International Journal of Molecular Sciences, 2019 Insulin in physiological concentrations is important to maintain vascular function. Moreover, vascular insulin resistance contributes to vascular impairment. In the elderly, other factors including hypertension, dyslipidemia, and chronic inflammation amplify senescence of vascular endothelial and smooth muscle cells.
Norihiko Sasaki +2 more
openaire +2 more sources
Vascular nitric oxide resistance in type 2 diabetes
Cell Death and Disease, 2023 Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO• in both the macro- and microvessels, is a common state in type 2 diabetes (T2D) associated with developing cardiovascular events and death.
Zahra Bahadoran +3 more
doaj +1 more source
Reduction in Hindquarter Vascular Resistance Supports 5-HT7 Receptor Mediated Hypotension
Frontiers in Physiology, 2021 The 5-HT7 receptor is the primary mediator of both the acute (<hours) and chronic (day-week) decreases in mean arterial pressure (MAP) during low dose 5-HT infusion in rats.
Bridget M. Seitz +2 more
doaj +1 more source
Mechanical response in elastic fluid flow networks [PDF]
arXiv, 2021 The dynamics of flow within a material transport network is dependent upon the dynamics of its power source. Responding to a change of these dynamics is critical for the fitness of living flow networks, e.g. the animal vasculature, which are subject to frequent and sudden shifts when the pump (the heart) transitions between different steady states. The
arxiv
The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment [PDF]
Elie Besserer-Offroy, et al. Pharmacol Res, Epub 9 March 2018, 2018 The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease.
arxiv +1 more source
The Pan African Medical Journal, 2019 INTRODUCTION: Sympathetic and Renin-Angiotensin-Aldosterone systems play crucial roles in blood pressure response to increased salt intake. This study investigated the effects of angiotensin receptor blocker (ARB) and sympathetic excitation on the ...
Francis Muyiwa Agbaraolorunpo +3 more
doaj +1 more source
Efficient Inference of Spatially-varying Gaussian Markov Random Fields with Applications in Gene Regulatory Networks [PDF]
arXiv, 2022 In this paper, we study the problem of inferring spatially-varying Gaussian Markov random fields (SV-GMRF) where the goal is to learn a network of sparse, context-specific GMRFs representing network relationships between genes. An important application of SV-GMRFs is in inference of gene regulatory networks from spatially-resolved transcriptomics ...
arxiv
Advanced Biomedical Research, 2015 Background: The pulsatility index (PI), measured by transcranial Doppler (TCD) ultrasonography, can reflect vascular resistance induced by cerebral small-vessel disease (SVD).
Abbas Ghorbani +2 more
doaj +1 more source
New England Journal of Medicine, 1998 BACKGROUND Primary (idiopathic) pulmonary hypertension is a progressive, fatal disease. Conventional therapy with anticoagulant and vasodilator drugs may improve symptoms and survival among selected patients, but there is no evidence that the disease can
V. McLaughlin +3 more
semanticscholar +1 more source