Results 71 to 80 of about 969,324 (357)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Changes in central and peripheral hemodynamic parameters during blood donation

Frontiers in Cardiovascular Medicine
BackgroundBlood donation is a common procedure, yet its acute effects on central and peripheral hemodynamics are not fully understood. This study aimed to systematically quantify immediate cardiovascular changes induced by whole blood donation in healthy
Babak Yazdani, Gökhan Yücel, Gökhan Yücel, Katrin Schulz, Sabine Kayser, Behnam Shaygi, Gerhard Schumacher, Janine Poschauko, Bernhard K. Krämer, Daniel Duerschmied, Daniel Duerschmied, Anna Hohneck, Anna Hohneck, Anna Hohneck   +13 more
doaj   +1 more source

Reduction in Hindquarter Vascular Resistance Supports 5-HT7 Receptor Mediated Hypotension

Frontiers in Physiology, 2021
The 5-HT7 receptor is the primary mediator of both the acute (<hours) and chronic (day-week) decreases in mean arterial pressure (MAP) during low dose 5-HT infusion in rats.
Bridget M. Seitz, Stephanie W. Watts, Gregory D. Fink   +2 more
doaj   +1 more source

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Adhering to a Tai Chi Chuan Exercise Program Improves Vascular Resistance and Cardiac Function

International Journal of Gerontology, 2011
Background: Cardiac function is an important predictor for life expectancy in elderly subjects. Tai Chi Chuan (TCC) is a generalized tolerable exercise for the aged population. The current study evaluated the effects of TCC on the vascular compliance and
Yin-Tsen Huang, Chun-Hsiung Wang, Yi-Fan Wu   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Regulation of Pulmonary Vascular Smooth Muscle Contractility in Pulmonary Arterial Hypertension: Implications for Therapy

Frontiers in Physiology, 2017
There are two primary components that produce pulmonary arterial hypertension (PAH); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary ...
Melissa A. Lyle, Jonathan P. Davis, Frank V. Brozovich   +2 more
doaj   +1 more source

Vascular nitric oxide resistance in type 2 diabetes

Cell Death and Disease, 2023
Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO• in both the macro- and microvessels, is a common state in type 2 diabetes (T2D) associated with developing cardiovascular events and death.
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi   +3 more
doaj   +1 more source

Vascular Injury After Whole Thoracic X-Ray Irradiation in the Rat [PDF]

, 2009
Purpose To study vascular injury after whole thoracic irradiation with single sublethal doses of X-rays in the rat and to develop markers that might predict the severity of injury.
Fish, B. L., Ghosh, S. N., Jacobs, Elizabeth R., Medhora, Meetha, Molthen, Robert C., Moulder, John E., Mäder, M., Wu, Q.   +7 more
core   +1 more source