Results 171 to 180 of about 2,150,532 (298)

Coordinated inflammatory macrophage and vascular smooth muscle cell remodeling signatures in human atherosclerosis: An integrative single-cell and bulk transcriptomic analysis. [PDF]

J Cell Commun Signal
Dong X, Hu X, Liu Q, Dong Y, Xuan Y, Wang M, Chang S, Lu T, Han Z.   +8 more
europepmc   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Dynamic insights into cellular mechanics and membrane undulations in vascular smooth muscle cells. [PDF]

Am J Physiol Cell Physiol
Khatiwada N, Sanyour HJ, Hammam IA, Li Z, McLean J, Dwamena A, Perez A, See GE, Wang H, Liu M, Hong Z.   +10 more
europepmc   +1 more source

Close relation of arterial ICC-like cells to the contractile phenotype of vascular smooth muscle cell [PDF]

, 2007
Gordienko, DV, Povstyan, O.V., Povstyan, OV, Oleksandr V. Povstyan, Gordienko, D.V., Vladimír Pucovský, Ray F. Moss, Bolton, T.B., Dmitri V. Gordienko, Bolton, TB, Moss, R.F., Harhun, M.I., Maksym I. Harhun, Thomas B. Bolton, Pucovský, V, Harhun, MI, Pucovsky, Vladimir, Moss, RF   +17 more
core   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

Hypotonicity-Induced WNK1 Phosphorylation Prevents H₂O₂-Induced Apoptosis in Vascular Smooth Muscle Cells. [PDF]

Basic Clin Pharmacol Toxicol
Zhang Y, Lin W, Lu F, Liang Z, Huang C, Mingming M, Sijia L, Ruiping P, Zhou J, Guan Y, Liang G, Lv X.   +11 more
europepmc   +1 more source

Designing Tissue Function Through Embedded Bioprinting Architectures

Advanced Science, EarlyView.
Embedded bioprinting enables soft, cell‐dense constructs to be fabricated within supporting bath environments. This review introduces a function‐guided framework linking target tissue functions to architectural requirements, supporting bath selection, bioink design, printing dynamics, and validation assays.
Qi Li, Yifei Cao, Jiaxin Lin, Huayong Yang, Hongzhao Zhou   +4 more
wiley   +1 more source

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source

Sphingolipid Signaling in Vascular Smooth Muscle Cells during Development and Diseases. [PDF]

JMA J
Dahal I, Sanderson C, Saito J.
europepmc   +1 more source

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source