Results 201 to 210 of about 2,150,532 (298)

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Heme-NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells. [PDF]

Adv Sci (Weinh)
Liu T, Zhang M, Zhu L, Ke H, de Souza A, Li Q, Castella D, Lehnert N, Zhang L, Blood AB.   +9 more
europepmc   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Diverse effects of calcineurin in vascular smooth muscle cells: physiological activators and the controversial actions of clinical inhibitors. [PDF]

Front Pharmacol
Nolze A, Grossmann C.
europepmc   +1 more source

Expert Consensus on the Management of Obesity in Older Adults (2026 Edition)

AGING MEDICINE, EarlyView.
This graphical abstract summarizes a safety‐first framework for managing obesity in older adults, with attention to age, functional status, comorbidities, and sarcopenia risk. Key assessments include BMI, waist measures, body fat percentage, skeletal muscle mass, and comprehensive geriatric evaluation. Management prioritizes reducing visceral fat while
Qi Pan, Lixin Guo
wiley   +1 more source

Role of Inositol Hexakisphosphate Kinases in Vascular Smooth Muscle Cell Calcification. [PDF]

Int J Mol Sci
Bahiraii S, Jannat I, Plösser S, Razazian M, Voelkl J, Alesutan I.   +5 more
europepmc   +1 more source

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, EarlyView.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

Neferine inhibits vascular smooth muscle cell proliferation and migration in atherosclerosis by targeting CYS130 and PHE252 in PTEN. [PDF]

Front Pharmacol
Jin Q, Liu Q, Ruan C, Xie Z, Gao X, Jiang Y, Jiang F, Xie B.   +7 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

<i>FGF18</i> aggravates angiotensin II-induced vascular smooth muscle cell dysfunction via the FGFR-ERK/AKT-GSK3β/β-catenin pathway. [PDF]

J Thorac Dis
He Y, Chen T, Xiang Y, Li D, Zhang H, Wu Z, He Y.   +6 more
europepmc   +1 more source