Results 251 to 260 of about 2,150,532 (298)
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Leptin and Vascular Smooth Muscle Cells
Current Pharmaceutical Design, 2014This review concerns the influence of leptin on vascular smooth muscle cells (VSMC). VSMC express different isoforms of the leptin receptor (Ob-R) able to activate a wide range of intracellular signalling pathways, mediating many relevant biological actions.
Mariella, Trovati +5 more
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1996
Smooth Muscle Tissue. The visceral mesenchyma (splanchnopleura) is the principal source for smooth muscle tissue. It also forms the layer-shaped muscle and connective tissue strata of the vessel walls. The vascular system of the human embryo develops from blood islets in the middle of the third week, shortly before somite formation, when the embryo can
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Smooth Muscle Tissue. The visceral mesenchyma (splanchnopleura) is the principal source for smooth muscle tissue. It also forms the layer-shaped muscle and connective tissue strata of the vessel walls. The vascular system of the human embryo develops from blood islets in the middle of the third week, shortly before somite formation, when the embryo can
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Oxygen sensors in vascular smooth muscle
Journal of Applied Physiology, 1994Inhibition or activation of cellular function due to acute decreases in PO2 can be considered in terms of two different processes: 1) a sensor that monitors PO2 decreases and 2) transduction systems directed from the O2 sensor to reactions that control cellular function.
Y, Katayama +3 more
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Intracellular Signaling in Vascular Smooth Muscle
1993The two major modalities of pharmacomechanical coupling, inositol 1,4,5, trisphosphate induced Ca2+ release and modulation of Ca(2+)-sensitivity, are reviewed. Recent studies show that although changes in cytoplasmic Ca2+ play the major role in regulating smooth muscle contraction, agonists can also significantly affect the contractile state by ...
A V, Somlyo, A P, Somlyo
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Gap junctions in vascular smooth muscle
Acta Physiologica Scandinavica, 1998Gap junction channels are the only class of channels which span two closely apposed plasma membranes. There are over a dozen identified subunit proteins or connexins. Three generic types of gap junction channels are possible. They are the homotypic, heterotypic and heteromeric types, each of which has a distinct connexin distribution.
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Actions of Nicorandil on Vascular Smooth Muscles
Journal of Cardiovascular Pharmacology, 1987The action of nicorandil on vascular smooth muscles has been studied in vitro using the microelectrode, Ca-transient, isometric tension recording methods, and the bioassay methods of cyclic nucleotides and inositol phospholipids. Nicorandil increased Ca-insensitive K conductance and hyperpolarized the membrane and thus prevented the activation of the ...
K, Sumimoto +6 more
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Effects of capsaicin on vascular smooth muscle
Naunyn-Schmiedeberg's Archives of Pharmacology, 1986Acute administration of capsaicin in vitro produced either vascular smooth muscle contraction (cat middle cerebral artery) or smooth muscle relaxation (guinea pig carotid artery and thoracic aorta). Prior in vivo treatment with capsaicin abolished the relaxation response of guinea pig vessels to acute capsaicin.
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Activation of cPLA2 in Vascular Smooth Muscle
1999Force regulation in vascular smooth muscle is under the control of a variety of lipid-dependent second messengers, such as inositol 1,4,5 trisphosphate and diacylglycerol (Hashimoto et al.,1986; Gu et al., 1991). Our laboratory has demonstrated that norepinephrine can induce force in rat tail artery via the stimulation of IP3 production and the ...
E F, LaBelle, E, Polyak
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MicroRNA and Vascular Smooth Muscle Cells
2011Vascular smooth muscle cells (VSMCs) exhibit extraordinary plasticity during postnatal development. Vascular injury initiates VSMC phenotypic switch from the contractile to proliferative phenotype, which plays a central role in vascular lesion formation and diverse vascular diseases.
Changqing, Xie +2 more
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Regulation of force in vascular smooth muscle
Journal of Molecular and Cellular Cardiology, 2003Vascular smooth muscle contraction plays a defining role in the regulation and maintenance of blood pressure, and its deregulation is associated with many clinical syndromes including hypertension, coronary vasospasm and congestive heart failure. Over the past 20 years, there has been a growing understanding of the regulation of 20 kDa myosin light ...
Ozgur, Ogut, Frank V, Brozovich
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