Results 121 to 130 of about 6,256,490 (293)

Finite element and mechanobiological modelling of vascular devices [PDF]

, 2011
There are two main surgical treatments for vascular diseases, (i) percutaneous stent deployment and (ii) replacement of an atherosclerotic artery with a vascular graft or tissue engineered blood vessel.
Zahedmanesh, Houman
core   +2 more sources

Endothelial–Vascular Smooth Muscle Cells Interactions in Atherosclerosis

Frontiers in Cardiovascular Medicine, 2018
Atherosclerosis is a chronic progressive inflammatory process that can eventually lead to cardiovascular disease (CVD). Despite available treatment, the prevalence of atherosclerotic CVD, which has become the leading cause of death worldwide, persists ...
Manna Li, Ming Qian, Kathy Kyler, Jian Xu   +3 more
doaj   +1 more source

A Hydrogen Sulfide–Releasing Dynamic Hydrogel Modulates Coordinated Neurovascular, Immune, and Angiogenic Responses for Scar‐Suppressed Diabetic Wound Repair

Advanced Science, EarlyView.
ROS‐Responsive H2S Hydrogel (HAPPF) Coordinated Regeneration for High‐Quality Diabetic Wound Repair.A self‐regulating dynamic hydrogel is developed to deliver a fluorogenic H2S donor in response to excessive ROS. Released H2S acts as a master regulator to resolve chronic inflammation (M2 polarization), restore VEGF‐driven angiogenesis, and rebalance ...
Xuyang Ning, Ziqiang Zhou, Bangming Li, Hong Lu, Haoyang Wen, Zhoulong Huang, Gang Li, Ping Hu   +7 more
wiley   +1 more source

Exosomal micro ribonucleic acid-154-5p derived from vascular smooth muscle cell mediates intracranial aneurysm phenotype in vitro via myosin light chain kinase targeting

Journal of International Medical Research
Objective The molecular pathogenesis of intracranial aneurysms remains undefined despite its central role in aneurysmal subarachnoid hemorrhage, a major cause of stroke and shock.
Jinhai Song, Wenkang Luan, Liang Chu, Pengjie Pan, Yao Qian, Yunpeng Lu   +5 more
doaj   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Arterial Blood‐Mediated Deep‐Tissue Photoacoustic Oximetry

Advanced Science, EarlyView.
The arterial prior method (APM+) for photoacoustic oximetry is introduced, which leverages the high arterial blood oxygenation to calibrate the fluence at the artery and estimate the oxygenation of the surrounding tissue, thus circumventing the spectral coloring problem. APM+’s accuracy and consistency are shown in a series of phantom and in vivo human
Karteekeya Sastry, Junhao Zhu, Joshua Olick‐Gibson, Li Lin, Lei Li, Jigmi Basumatary, Yang Zhang, Lihong V. Wang   +7 more
wiley   +1 more source

NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension

JCI Insight
NKX2-5 is a member of the homeobox-containing transcription factors critical in regulating tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth muscle cell phenotypic modulation in vitro and in vascular remodeling ...
Ioannis Papaioannou, Athina Dritsoula, Ping Kang, Reshma S. Baliga, Sarah L. Trinder, Emma Cook, Xu Shiwen, Adrian J. Hobbs, Christopher P. Denton, David J. Abraham, Markella Ponticos   +10 more
doaj   +1 more source

Mechanism of action and potential therapeutic targets of TGF-β-related signaling pathway and its downstream miRNA expression in pulmonary arterial hypertension

Frontiers in Pharmacology
Pulmonary hypertension is a major cardiovascular disease characterized by the persistent elevation of pulmonary artery pressure, leading to vascular remodeling, fibrosis, and endothelial dysfunction.
Yimo Huang, Wende Ma, Cen Guo, Cen Guo, Xiaoling Su   +4 more
doaj   +1 more source

Smooth Muscle Cells in Vascular Remodeling [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Ning, Shi, Xiaohan, Mei, Shi-You, Chen
openaire   +2 more sources

The investigation of corpus cavernosum smooth muscle dysfunction in low-flow priapism. [PDF]

, 2007
Prolonged low-flow (ischaemic) priapism results in a progressive alteration of the microenvironment within the corpus cavemosum with the development of hypoxia, acidosis and glucopenia and a reduction in the responsiveness to a-adrenergic receptor ...
Muneer, A., Muneer, Asif
core