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Production of Endothelin by Vascular Smooth Muscle Cells
Journal of Cardiovascular Pharmacology, 1991Endothelin (ET) production by cultured vascular smooth muscle cells isolated from rat and rabbit aortae was measured by a specific radioimmunoassay. Vascular smooth muscle cells released ET at a rate of 0.6 (range of 0.1-1) fmol/10(5) cells/24 h compared to 45 (range of 10-80) fmol/10(5) cells/h for endothelial cells.
KANSE SM +6 more
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Thrombin and Proliferation of Vascular Smooth Muscle Cells
Circulation Research, 1995Thrombin is a well-established promoter of vascular SMC proliferation in vitro. A similar role has been suggested but not yet proven in vivo. The effect is mediated via selective receptors expressed on vascular SMCs in vitro. Activation of the thrombin receptor leads to a number of intracellular signaling events as well as to stimulation of endogenous ...
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Regulation of vascular smooth muscle cells by micropatterning
Biochemical and Biophysical Research Communications, 2003Vascular smooth muscle cells (SMCs) undergo morphological and phenotypic changes when cultured in vitro. To investigate whether SMC morphology regulates SMC functions, bovine aortic SMCs were grown on micropatterned collagen strips (50-, 30-, and 20-microm wide).
Rahul G, Thakar +4 more
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Lysolecithin actions on vascular smooth muscle cells
Biochemical and Biophysical Research Communications, 1992Oxidation of low density lipoprotein increases its atherogenic potential. During oxidation there is an extensive conversion of lecithin to lysolecithin. In rat aortic smooth muscle cells, 2-25 micrograms/ml lysolecithin elevated cytosolic calcium concentration up to 560%.
Locher R +4 more
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Calcium Channels in Vascular Smooth Muscle Cells
Journal of Vascular Research, 2008Control of intracellular Ca2+ ([Ca2+]<sub>i</sub>) is critical to vascular smooth muscle function. Calcium channels are the major route by which Ca2+ enters the smooth muscle cell. This article reviews the types of calcium channel present in vascular smooth muscle cells and their physiological and biochemical regulation.
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Vascular smooth muscle cells and calcification in atherosclerosis
American Heart Journal, 2004Vascular calcification is a prominent feature of atherosclerosis but the mechanisms underlying vascular calcification are still obscure. Since bone-associated proteins such as osteonectin, osteocalcin, and matrix Gla protein have been detected in calcified vascular tissues, calcification has been considered to be an organized, regulated process similar
Astrid, Trion, Arnoud, van der Laarse
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The roles of autophagy in vascular smooth muscle cells
International Journal of Cardiology, 2016Autophagy, which is an evolutionarily conserved mechanism and links to several cellular pathways, impacts vascular smooth muscle cells (VSMCs) survival and function. Activation of autophagy by intercellular and/or extracellular stimuli has protective effects on VSMCs against cell death, while on the contrary, overloading autophagy has been recognized ...
Shi, Tai +4 more
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Pathophysiological Role of the Vascular Smooth Muscle Cell
Journal of Cardiovascular Pharmacology, 1990The vascular smooth muscle cell of the arterial media plays a predominant role in functional and structural alterations of the arterial wall in pathophysiological processes such as arterial hypertension, atheroma, or normal aging. The observed alterations are related to the three activities of the vascular smooth muscle cell, namely contractility ...
J B, Michel +5 more
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Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis
Journal of the American Heart Association, 2023Shu Ye +2 more
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Cellular Crosstalk between Endothelial and Smooth Muscle Cells in Vascular Wall Remodeling
International Journal of Molecular Sciences, 2021Luis Miguel Blanco-Colio
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