Vascular Stiffness in Aging and Disease [PDF]
Frontiers in Physiology, 2021 The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases.
Stephen F. Vatner +5 more
doaj +5 more sources
Vascular aging, the vascular cytoskeleton and aortic stiffness [PDF]
Exploration of Medicine, 2021 Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC).
Lova Prasadareddy Kajuluri +2 more
doaj +4 more sources
Inter- and intradialytic fluid volume changes and vascular stiffness parameters in patients on hemodialysis. [PDF]
PLoS ONE, 2022 BackgroundWhether fluid overload is associated with vascular stiffness parameters in hemodialysis (HD) patients has not been fully elucidated. We hypothesized that interdialytic fluid accumulation increases vascular stiffness parameters, which improves ...
Aya Lafta +6 more
doaj +2 more sources
Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD [PDF]
JCI InsightIKK2/NF-κB pathway–mediated inflammation in vascular smooth muscle cells (VSMCs) has been proposed to be an etiologic factor in medial calcification and stiffness.
Shinobu Miyazaki-Anzai +5 more
doaj +2 more sources
Characterization of di‐gital, tri‐gital, and tetra‐gital temporal movement of systolic blood pressure on the arterial pulse waveform of rats at different vascular stiffness [PDF]
Animal Models and Experimental MedicineBackground An arterial stiffness is an indicator of many cardiovascular diseases. The temporal position of systolic blood pressure (BP) on aorta pulse waveform is assumed to gradually shift on the waveform in response to increasing/decreasing vascular ...
Anton Misak +3 more
doaj +2 more sources
A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. [PDF]
PLoS ONE, 2013 BACKGROUND: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community ...
Masashi Kitagawa +13 more
doaj +5 more sources
Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension [PDF]
, 2012 Objectives: Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value $155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify ...
Arturi, F +8 more
core +12 more sources
Frontiers in Cardiovascular Medicine, 2023 BackgroundArterial stiffness and medial vascular calcification, leading to isolated systolic blood pressure (BP), are major cardiovascular risk factors in patients with chronic kidney disease (CKD) and mineral bone disorders (MBD).
Richard Larivière +9 more
doaj +1 more source
Substrate stiffness differentially impacts autophagy of endothelial cells and smooth muscle cells
Bioactive Materials, 2021 Stiffening of blood vessels is one of the most important characteristics in the process of many cardiovascular pathologies such as atherosclerosis, angiosteosis, and vascular aging.
Mi Hu +9 more
doaj +1 more source
Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]
, 2018 BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna +10 more
core +4 more sources