Vascular Stiffness in Aging and Disease [PDF]
Frontiers in Physiology, 2021 The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases.
S. Vatner +5 more
semanticscholar +4 more sources
Inhibition of the Histone Methyltransferase EZH2 Induces Vascular Stiffness. [PDF]
Clin Sci (Lond), 2023 Vascular stiffness increases with aging, obesity and hypertension and predicts cardiovascular risk. The levels of histone H3-lysine-27 methylation(H3K27me) and the histone methyltransferase EZH2 both decrease in aging vessels, driving vascular stiffness.
Jaime Ibarrola +5 more
semanticscholar +2 more sources
Association between one-hour post-load plasma glucose levels and vascular stiffness in essential hypertension [PDF]
PLoS ONE, 2012 Objectives: Pulse wave velocity (PWV) is a surrogate end-point for cardiovascular morbidity and mortality. A plasma glucose value $155 mg/dl for the 1-hour post-load plasma glucose during an oral glucose tolerance test (OGTT) is able to identify ...
Arturi, F +8 more
core +22 more sources
Cystamine reduces vascular stiffness in Western diet-fed female mice.
Am J Physiol Heart Circ Physiol, 2021 Consumption of diets high in fat, sugar and salt (Western diet, WD) is associated with accelerated arterial stiffening, a major independent risk factor for cardiovascular disease (CVD). Obese women are more prone to develop arterial stiffening leading to
Francisco I. Ramirez-Perez +14 more
semanticscholar +2 more sources
Platelet-Derived Extracellular Vesicles Increase Col8a1 Secretion and Vascular Stiffness in Intimal Injury [PDF]
Front Cell Dev Biol, 2021 The arterial mechanical microenvironment, including stiffness, is a crucial pathophysiological feature of vascular remodeling, such as neointimal hyperplasia after carotid endarterectomy and balloon dilatation surgeries.
H. Bao +12 more
semanticscholar +2 more sources
Sacubitril/valsartan inhibits obesity-associated diastolic dysfunction through suppression of ventricular-vascular stiffness [PDF]
Cardiovasc Diabetol, 2021 Objective Cardiac diastolic dysfunction (DD) and arterial stiffness are early manifestations of obesity-associated prediabetes, and both serve as risk factors for the development of heart failure with preserved ejection fraction (HFpEF).
A. Aroor +8 more
semanticscholar +2 more sources
J Am Soc Nephrol, 2020 BACKGROUND Vascular calcification, a risk factor for cardiovascular disease, is common among patients with CKD and is an independent contributor to increased vascular stiffness and vascular risk in this patient group. Vitamin K is a cofactor for proteins
Miles D. Witham +20 more
semanticscholar +2 more sources
Cardiovascular Diabetology, 2021 Advanced glycation end-products are proteins that become glycated after contact with sugars and are implicated in endothelial dysfunction and arterial stiffening. We aimed to investigate the relationships between advanced glycation end-products, measured
A. Birukov +4 more
semanticscholar +1 more source
Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]
, 2018 Background: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
AortaGen Consortium, the +20 more
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Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer? [PDF]
, 2013 Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis.
A Evans +34 more
core +3 more sources