Vascular Stiffness in Aging and Disease [PDF]
Frontiers in Physiology, 2021 The goal of this review is to provide further understanding of increased vascular stiffness with aging, and how it contributes to the adverse effects of major human diseases.
Stephen F. Vatner +5 more
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Inhibition of the histone methyltransferase EZH2 induces vascular stiffness. [PDF]
Clin Sci (Lond), 2023 Vascular stiffness increases with aging, obesity and hypertension and predicts cardiovascular risk. The levels of histone H3-lysine-27 methylation(H3K27me) and the histone methyltransferase EZH2 both decrease in aging vessels, driving vascular stiffness.
Ibarrola J +5 more
europepmc +4 more sources
Association of the human gut microbiota with vascular stiffness. [PDF]
Sci Rep, 2023 Gut microbiota metabolites have been mechanistically linked to inflammatory pathway activation and atherosclerosis, which are major causes of vascular stiffness (VS).
Cuadrat RRC +8 more
europepmc +9 more sources
Inter- and intradialytic fluid volume changes and vascular stiffness parameters in patients on hemodialysis. [PDF]
PLoS ONE, 2022 BackgroundWhether fluid overload is associated with vascular stiffness parameters in hemodialysis (HD) patients has not been fully elucidated. We hypothesized that interdialytic fluid accumulation increases vascular stiffness parameters, which improves ...
Aya Lafta +6 more
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Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Signal Transduction and Targeted TherapyCardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by structural (e.g.,
Maximilian Jonathan Herzog +9 more
doaj +4 more sources
Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging [PDF]
Scientific ReportsArterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta and the ...
Callan D. Wesley +4 more
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Platelet-Derived Extracellular Vesicles Increase Col8a1 Secretion and Vascular Stiffness in Intimal Injury. [PDF]
Front Cell Dev Biol, 2021 The arterial mechanical microenvironment, including stiffness, is a crucial pathophysiological feature of vascular remodeling, such as neointimal hyperplasia after carotid endarterectomy and balloon dilatation surgeries.
Bao H +12 more
europepmc +2 more sources
Cystamine reduces vascular stiffness in Western diet-fed female mice.
Am J Physiol Heart Circ Physiol, 2022 Consumption of diets high in fat, sugar and salt (Western diet, WD) is associated with accelerated arterial stiffening, a major independent risk factor for cardiovascular disease (CVD). Obese women are more prone to develop arterial stiffening leading to
Ramirez-Perez FI +14 more
europepmc +2 more sources
VASCULAR WALL STIFFNESS IN PATIENTS WITH ANKYLOSING SPONDYLITIS: RESULTS OF A MULTICENTER STUDY
Klinicist, 2015 Objective: to study some vascular wall stiffness parameters in patients with ankylosing spondylitis (AS) without clinically manifest cardio vascular diseases. Subjects and methods.
I. Z. Gaydukova +5 more
doaj +2 more sources
Activation of the IKK2/NF-κB pathway in VSMCs inhibits calcified vascular stiffness in CKD [PDF]
JCI InsightIKK2/NF-κB pathway–mediated inflammation in vascular smooth muscle cells (VSMCs) has been proposed to be an etiologic factor in medial calcification and stiffness.
Shinobu Miyazaki-Anzai +5 more
doaj +2 more sources