Results 41 to 50 of about 2,119,107 (327)

Smooth Muscle Cell Stiffness Syndrome – Revisiting the Structural Basis of Arterial Stiffness

Frontiers in Physiology, 2015
In recent decades, the pervasiveness of increased arterial stiffness in patients with cardiovascular disease has become increasingly apparent. Though this phenomenon has been well documented in humans and animal models of disease for well over a century,
Nancy L. Sehgel, Nancy L. Sehgel, Stephen F. Vatner, Gerald A Meininger   +3 more
doaj   +1 more source

Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial.

Journal of the American Society of Nephrology, 2020
BACKGROUND Vascular calcification, a risk factor for cardiovascular disease, is common among patients with CKD and is an independent contributor to increased vascular stiffness and vascular risk in this patient group. Vitamin K is a cofactor for proteins
M. Witham, J. Lees, Myra White, Margaret M Band, Samira Bell, D. Chantler, Ian Ford, Roberta L. Fulton, G. Kennedy, Roberta Littleford, I. McCrea, D. McGlynn, Maurizio Panarelli, M. Ralston, E. Rutherford, Alison Severn, Nicola Thomson, J. Traynor, A. D. Struthers, K. Wetherall, Patrick B. Mark   +20 more
semanticscholar   +1 more source

Progression of endothelial dysfunction, atherosclerosis, and arterial stiffness in stable kidney transplant patients: a pilot study. [PDF]

, 2020
BACKGROUND: Kidney transplant patients suffer from vascular abnormalities and high cardiovascular event rates, despite initial improvements post-transplantation. The nature of the progression of vascular abnormalities in the longer term is unknown.
Banerjee, D, Hojs, N, Junarta, J, Kaski, JC, Lowe-Jones, R, Ramphul, R   +5 more
core   +1 more source

Mechanisms of Increased Vascular Stiffness Down the Aortic Tree in Aging, Pre-Menopausal Female Monkeys.

American Journal of Physiology. Heart and Circulatory Physiology, 2020
OBJECTIVE Protection against increased vascular stiffness in young women is lost after menopause. However, little is known about vascular stiffness in older, pre-menopausal females, because most of the prior work has been conducted in rodents, which live
Denis Babici, R. Kudej, Tara McNulty, Jie Zhang, Marko Oydanich, Tolga Berkman, K. Nishimura, S. Bishop, D. Vatner, S. Vatner   +9 more
semanticscholar   +1 more source

Substrate stiffness and VE-cadherin mechano-transduction coordinate to regulate endothelial monolayer integrity. [PDF]

, 2017
The vascular endothelium is subject to diverse mechanical cues that regulate vascular endothelial barrier function. In addition to rigidity sensing through integrin adhesions, mechanical perturbations such as changes in fluid shear stress can also ...
Andresen Eguiluz, Roberto C, Kaylan, Kerim B, Leckband, Deborah E, Underhill, Gregory H   +3 more
core   +1 more source

RhoBTB1 reverses established arterial stiffness in angiotensin II–induced hypertension by promoting actin depolymerization

JCI Insight, 2022
Arterial stiffness predicts cardiovascular disease and all-cause mortality, but its treatment remains challenging. Mice treated with angiotensin II (Ang II) develop hypertension, arterial stiffness, vascular dysfunction, and a downregulation of Rho ...
Shi Fang, Jing Wu, John J. Reho, Ko-Ting Lu, Daniel T. Brozoski, Gaurav Kumar, Alec M. Werthman, Sebastiao Donato Silva Jr., Patricia C. Muskus Veitia, Kelsey K. Wackman, Angela J. Mathison, Bi Qing Teng, Chien-Wei Lin, Frederick W. Quelle, Curt D. Sigmund   +14 more
doaj   +1 more source

Adipokines and Arterial Stiffness in Obesity

Medicina, 2021
Adipokines are active molecules with pleiotropic effects produced by adipose tissue and involved in obesity-related metabolic and cardiovascular diseases. Arterial stiffness, which is a consequence of arteriosclerosis, has been shown to be an independent
Ioana Para, Adriana Albu, Mihai D. Porojan   +2 more
doaj   +1 more source

Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging

PLoS ONE, 2020
Purpose Pulse wave velocity (PWV), an indicator of vascular stiffness, increases with age and is increasingly recognized as an independent risk factor for cardiovascular disease (CVD).
Sunao Shimizu, J. Mimura, Takanori Hasegawa, Eigo Shimizu, S. Imoto, Michiko Tsushima, S. Kasai, Hiromi Yamazaki, Yusuke Ushida, H. Suganuma, H. Tomita, Masayuki Yamamoto, S. Nakaji, K. Itoh   +13 more
semanticscholar   +1 more source

Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study [PDF]

, 2014
Introduction: Excess aldosterone is associated with increased cardiovascular risk. Aldosterone has a permissive effect on vascular fibrosis. Cardiovascular magnetic resonance imaging (CMR) allows study of vascular function by measuring aortic ...
A McCurley, A Rudolph, A Tomaschitz, B Fink, B Strauch, B Strauch, C Catena, C Delles, C Delles, CB Stehr, D Rizzoni, DA Calhoun, E M Freel, E P McQuarrie, EM Freel, G Bernini, GE Callera, GF Mitchell, GP Rossi, JM Connell, JW Funder, K Gaddam, L U Zimmerli, LU Zimmerli, MJ van Trijp, MR Robinson, NC Edwards, OJ Rider, OJ Rider, P B Mark, P Milliez, P Rerkpattanapipat, PB Mark, R Holaj, R Rocha, RB Stacey, S Boyle, S Laurent, T Indra, WJ Rogers, YH Lin   +40 more
core   +1 more source

Elevated Exercise Blood Pressure in Middle Aged Women is associated with altered Left Ventricular and Vascular Stiffness.

Journal of applied physiology, 2020
Women are at higher risk for developing heart failure with preserved ejection fraction (HFpEF). We examined the utility of peak exercise blood pressure (BP) in identifying pre-clinical features of HFpEF, namely vascular and cardiac stiffness in middle ...
S. Sarma, E. Howden, G. Carrick-Ranson, Justin S. Lawley, C. Hearon, M. Samels, Braden Everding, S. Livingston, B. Adams-Huet, M. D. Palmer, B. Levine   +10 more
semanticscholar   +1 more source