Results 51 to 60 of about 128,544 (288)

Relative Contributions of Age and Atherosclerosis to Vascular Stiffness [PDF]

Clinical and Translational Science, 2008
AbstractTo determine the relative contributions of aging and atherosclerosis to vascular stiffness, we studied aortic stiffness, plaque, and elastin in 8‐, 16‐, 25‐, and 34‐week‐old male ApoE‐KO and C57BL/6J control mice (N = 48). Stiffness increased gradually in both strains up to 25 weeks (p < 0.05), and dramatically between 25 and 34 weeks in ...
Linda C, Santelices, Sarah J, Rutman, Rachelle, Prantil-Baun, David A, Vorp, Joseph M, Ahearn   +4 more
openaire   +2 more sources

Age and vascular aging: an unexplored frontier

Frontiers in Cardiovascular Medicine, 2023
Vascular age is an emerging field in cardiovascular risk assessment. This concept includes multifactorial changes in the arterial wall, with arterial stiffness as its most relevant manifestation, leading to increased arterial pressure and pulsatile flow ...
Laura del Mar González, Sara P. Romero-Orjuela, Fernando J. Rabeya, Valeria del Castillo, Darío Echeverri   +4 more
doaj   +1 more source

A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. [PDF]

PLoS ONE, 2013
BACKGROUND: Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans. In humans, low serum Klotho levels are related to the prevalence of cardiovascular diseases in community ...
Masashi Kitagawa, Hitoshi Sugiyama, Hiroshi Morinaga, Tatsuyuki Inoue, Keiichi Takiue, Ayu Ogawa, Toshio Yamanari, Yoko Kikumoto, Haruhito Adam Uchida, Shinji Kitamura, Yohei Maeshima, Kazufumi Nakamura, Hiroshi Ito, Hirofumi Makino   +13 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ARTERIAL STIFFNESS AS A RISK FACTOR FOR CEREBRAL VASCULAR LESIONS

Artery Research, 2018
Increased arterial stiffness, a biomarker of vascular aging, is a recognized subclinical organ damage, and may thus serve as predictor of cardiovascular disease.
Dariusz Gasecki
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Impact of Vitamin D Supplementation on Arterial Vasomotion, Stiffness and Endothelial Biomarkers in Chronic Kidney Disease Patients

, 2014
Background: Cardiovascular events are frequent and vascular endothelial function is abnormal in patients with chronic kidney disease (CKD). We demonstrated endothelial dysfunction with vitamin D deficiency in CKD patients; however the impact of ...
Chitalia, N, Hampson, G, Tooth, L, Ismail Tuan, Nihil Chitalia, Debasish Banerjee (539268), Chitalia Nihil, Laura Tooth, Banerjee, D, Ismail, T, Laura Tooth (539265), Geeta Hampson (68251), David Goldsmith (539267), Banerjee Debasish, Boa, F, Juan Carlos Kaski, Kaski Juan Carlos, Tooth Laura, Hampson Geeta, Boa Frances, Nihil Chitalia (539263), Juan Carlos Kaski (248043), Frances Boa (539266), Goldsmith David, Tuan Ismail (539264), Debasish Banerjee, Kaski, JC, David Goldsmith, Geeta Hampson, Tuan Ismail, Goldsmith, D, Frances Boa   +31 more
core   +1 more source

Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging

Scientific Reports
Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta and the ...
Callan D. Wesley, Cedric H. G. Neutel, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns   +4 more
doaj   +1 more source

Matrix Stiffness Induces Pericyte-Fibroblast Transition Through YAP Activation

Frontiers in Pharmacology, 2021
Vascular pericytes, important mural cells that retain progenitor cell properties and protect vascular integrity in healthy tissues, are often associated with tumor development, but their functions in cancer invasion remain elusive.
Feng Feng, Feng Feng, Xueyan Feng, Xueyan Feng, Di Zhang, Di Zhang, Qilong Li, Qilong Li, Li Yao, Li Yao   +9 more
doaj   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source