Results 141 to 150 of about 202,203 (296)

Prevalence of Early Vascular Aging Syndrome in Men Working Under Noise Exposure

open access: yesАрхивъ внутренней медицины
Noise can be one of the factors provoking the premature development of changes in the artery wall associated with age. Aim: to assess the stiffness of the vascular wall and the prevalence of early vascular aging syndrome in men of working age, depending ...
M. D. Rudoi
doaj   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

open access: yesAdvanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim   +6 more
wiley   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

open access: yesAdvanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni   +15 more
wiley   +1 more source

Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part I

open access: yesPulse
Background: Engaging in habitual resistance exercise training (RET; also known as strength training) causes systemic health effects beyond those caused by aerobic/endurance exercise training alone.
Denis J. Wakeham   +2 more
doaj   +1 more source

Survivin modulates stiffness-induced vascular smooth muscle cell motility

open access: yesAPL Bioengineering
Arterial stiffness is a contributor to cardiovascular diseases (CVDs) and is associated with the aberrant migration of vascular smooth muscle cells (VSMCs). However, the mechanisms driving VSMC migration in stiff environments remain unclear. We recently demonstrated that survivin is upregulated in mouse and human VSMCs cultured on stiff hydrogels ...
Thomas Mousso   +8 more
openaire   +3 more sources

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

open access: yesAdvanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi   +2 more
wiley   +1 more source

Prospects for a comprehensive assessment of sclerostin, arterial calcification and stiffness in the context of coronary heart disease

open access: yesSiberian Journal of Life Sciences and Agriculture
Background. Coronary heart disease is accompanied by increased calcification and vascular stiffness, which is associated with an increased risk of adverse cardiovascular events. This manuscript focuses on the contribution of sclerostin to the development
Irina A. Snimshchikova   +3 more
doaj   +1 more source

Parameter Inference in the Pulmonary Circulation of Mice [PDF]

open access: yes, 2017
This study focuses on parameter inference in a pulmonary blood cir- culation model for mice. It utilises a fluid dynamics network model that takes selected parameter values and aims to mimic features of the pulmonary haemody- namics under normal ...
Colebank, Mitchel   +6 more
core  

Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues

open access: yesAdvanced Healthcare Materials, EarlyView.
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman   +7 more
wiley   +1 more source

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