Results 31 to 40 of about 7,952,783 (243)

Vascular miR‐181b controls tissue factor‐dependent thrombogenicity and inflammation in type 2 diabetes [PDF]

, 2020
BACKGROUND: Diabetes mellitus is characterized by chronic vascular inflammation leading to pathological expression of the thrombogenic full length (fl) tissue factor (TF) and its isoform alternatively-spliced (as) TF. Blood-borne TF promotes factor (
Chakraborty, Aritra, Dörner, Andrea, Friebel, Julian, Krueger, Andreas, Landmesser, Ulf, Rauch, Ursula, Ruf, Wolfram, Saffarzadeh, Mona, Stratmann, Bernd, Ta Bao, Loc, Tabaraie, Termeh, Tschoepe, Diethelm, Winter, Samantha J., Witkowski, Marco, Witkowski, Mario   +14 more
core   +1 more source

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

Cell Reports, 2015
Normalization of the tumor vasculature is an emerging concept shown to improve anti-cancer therapy. However, there are currently no clinical interventions that effect long-lasting normalization.
Anna Johansson-Percival, Zhi-Jie Li, Devina D. Lakhiani, Bo He, Xiao Wang, Juliana Hamzah, Ruth Ganss   +6 more
doaj   +1 more source

Targeting Epigenetic Mechanisms in Vascular Aging

Frontiers in Cardiovascular Medicine, 2022
Environment, diseases, lack of exercise, and aged tendency of population have becoming crucial factors that induce vascular aging. Vascular aging is unmodifiable risk factor for diseases like diabetes, hypertension, atherosclerosis, and hyperlipidemia ...
Zhongxiao Lin, Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu, YiZhun Zhu   +8 more
doaj   +1 more source

MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase [PDF]

, 2019
Nicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling.
Chen, Jiwang, Chen, Tianji, Dong, Yangbasai, Gao, Hui, Machado, Roberto F., Song, Yang, Wang, Yifang, Zhao, Shuangping   +7 more
core   +1 more source

Targeting drug delivery in the vascular system: Focus on endothelium

Advanced Drug Delivery Reviews, 2020
The bloodstream is the main transporting pathway for drug delivery systems (DDS) from the site of administration to the intended site of action. In many cases, components of the vascular system represent therapeutic targets. Endothelial cells, which line
P. Glassman, J. Myerson, Laura T. Ferguson, R. Kiseleva, V. Shuvaev, J. Brenner, V. Muzykantov   +6 more
semanticscholar   +1 more source

Efficacy of tumor-targeting Salmonella typhimurium A1-R in combination with anti-angiogenesis therapy on a pancreatic cancer patient-derived orthotopic xenograft (PDOX) and cell line mouse models. [PDF]

, 2014
The aim of the present study was to examine the efficacy of tumor-targeting Salmonella typhimurium A1-R treatment following anti-vascular endothelial growth factor (VEGF) therapy on VEGF-positive human pancreatic cancer.
Bouvet, Michael, Chishima, Takashi, Endo, Itaru, Hiroshima, Yukihiko, Hoffman, Robert M, Ichikawa, Yasushi, Maawy, Ali, Matsuyama, Ryusei, Miwa, Shinji, Momiyama, Masashi, Mori, Ryutaro, Murakami, Takashi, Sato, Sho, Tanaka, Kuniya, Yamamoto, Mako, Yano, Shuya, Zhang, Yong, Zhao, Ming   +17 more
core   +2 more sources

Novel Therapies Targeting Vascular Endothelium

Endothelium, 2006
Endothelial dysfunction has been identified as a major mechanism involved in all the stages of atherogenesis. Evaluation of endothelial function seems to have a predictive role in humans, and therapeutic interventions improving nitric oxide bioavailability in the vasculature may improve the long-term outcome in healthy individuals, high-risk subjects ...
Tousoulis, Dimitris, Antoniades, Charalambos, Koumallos, Nikolaos, Marinou, Kyriakoula, Stefanadi, Elli, Latsios, George, Stefanadis, Christodoulos   +6 more
openaire   +3 more sources

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited [PDF]

, 2012
The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2)
Dumont, Daniel J., Plate, Karl H., Scholz, Alexander   +2 more
core   +1 more source

Diffusion-Weighted Magnetic Resonance Imaging Allows Noninvasive In Vivo Monitoring of the Effects of Combretastatin A-4 Phosphate after Repeated Administration

Neoplasia: An International Journal for Oncology Research, 2005
The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 ...
Harriet C. Thoeny, Frederik De Keyzer, Feng Chen, Vincent Vandecaveye, Erik K. Verbeken, Bisan Ahmed, Xihe Sun, Yicheng Ni, Hilde Bosmans, Robert Hermans, Allan van Oosterom, Guy Marchal, Willy Landuyt   +12 more
doaj   +1 more source