Results 11 to 20 of about 1,860,910 (290)

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core   +6 more sources

Development of a Combined Lipid-Based Nanoparticle Formulation for Enhanced siRNA Delivery to Vascular Endothelial Cells

Pharmaceutics, 2022
Low transfection efficiency in endothelial cells (EC) is still a bottleneck for the majority of siRNA-based vascular delivery approaches. In this work, we developed a lipid-based nanoparticle (LNP) formulation based on a combination of a permanently ...
Yutong He, Dongdong Bi, Josée A. Plantinga, Grietje Molema, Jeroen Bussmann, Jan A. A. M. Kamps   +5 more
doaj   +1 more source

Targeting the Blood–Brain Tumor Barrier with Tumor Necrosis Factor-α

Pharmaceutics, 2022
The blood–brain tumor barrier represents a major obstacle for anticancer drug delivery to brain tumors. Thus, novel strategies aimed at targeting and breaching this structure are of great experimental and clinical interest.
Angelo Corti, Teresa Calimeri, Flavio Curnis, Andres J. M. Ferreri   +3 more
doaj   +1 more source

Co-Administration of Vadimezan and Recombinant Coagulase-NGR Inhibits Growth of Melanoma Tumor in Mice [PDF]

Advanced Pharmaceutical Bulletin, 2021
Purpose: Tumor vascular targeting appeared as an appealing approach to fight cancer, though, the results from the clinical trials and drugs in the market were proved otherwise.
Amir Daei Farshchi Adli, Rana Jahanban-Esfahlan, Khaled Seidi, Davoud Farajzadeh, Ramezan Behzadi, Nosratollah Zarghami   +5 more
doaj   +1 more source

Targeting vascular (endothelial) dysfunction [PDF]

British Journal of Pharmacology, 2016
AbstractCardiovascular diseases are major contributors to global deaths and disability‐adjusted life years, with hypertension a significant risk factor for all causes of death. The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, circulation of blood cells, inflammation and ...
Andreas, Daiber, Sebastian, Steven, Alina, Weber, Vladimir V, Shuvaev, Vladimir R, Muzykantov, Ismail, Laher, Huige, Li, Santiago, Lamas, Thomas, Münzel   +8 more
openaire   +2 more sources

Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy

Cell Reports, 2020
Summary: Due to limited current therapies, metastases are the primary cause of mortality in cancer patients. Here, we employ a fusion compound of the cytokine LIGHT and a vascular targeting peptide (LIGHT-VTP) that homes to angiogenic blood vessels in ...
Bo He, Anna Johansson-Percival, Joseph Backhouse, Ji Li, Gabriel Yin Foo Lee, Juliana Hamzah, Ruth Ganss   +6 more
doaj   +1 more source

Vascular targeting of antithrombotic agents [PDF]

IUBMB Life, 2011
AbstractIn this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti‐thrombotic agents to fibrin, platelets, red blood cells and endothelium.
Ronald, Carnemolla, Vladimir R, Muzykantov   +1 more
openaire   +2 more sources

Vascular targeted therapies in oncology [PDF]

Cell and Tissue Research, 2008
Neovascularization is intimately involved in tumor survival, progression, and spread, factors known to contribute significantly to treatment failures. Thus, strategies targeting the tumor blood vessel support network may offer not only unique therapeutic opportunities in their own right, but also novel means of enhancing the efficacies of conventional ...
Siemann, Dietmar W, Horsman, Michael R
openaire   +2 more sources

Targeted treatment of vascular anomalies

International Journal of Women's Dermatology, 2021
Vascular anomalies comprise an array of congenital developmental disorders that can lead to significant disfigurement and physiologic disarray. The vast multitude of clinical phenotypes has inherently led to misdiagnosis and patients and families enduring long diagnostic odysseys of medical care.
Ashley T. Ng, Richard L. Tower, Beth A. Drolet   +2 more
openaire   +3 more sources

Tumour dose response to the antivascular agent ZD6126 assessed by magnetic resonance imaging [PDF]

, 2003
ZD6126 is a vascular targeting agent that disrupts the tubulin cytoskeleton of proliferating neo-endothelial cells. This leads to the selective destruction and congestion of tumour blood vessels in experimental tumours, resulting in extensive ...
J R Griffiths, McIntyre, D. J O, Blakey, D. C., Checkley, D, Blakey, DC, Griffiths, J. R., A J Ryan, Howe, F. A., D Checkley, McIntyre, DJ, Waterton, JC, D J O McIntyre, Robinson, S. P., S P Robinson, Robinson, SP, S E Ashton, F A Howe, D C Blakey, Griffiths, JR, Waterton, J. C., Ryan, AJ, Ryan, A. J., Tessier, JJ, Howe, FA, Checkley, D., Tessier, J. J., Ashton, SE, Ashton, S. E., J J Tessier, J C Waterton   +29 more
core   +1 more source