Results 21 to 30 of about 1,860,910 (290)

Increased Targeting Area in Tumors by Dual-Ligand Modification of Liposomes with RGD and TAT Peptides

Pharmaceutics, 2022
Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids drastically improve the pharmacokinetics of chemotherapeutics and result in more manageable or reduced side-effects.
Mohamadreza Amin, Mercedeh Mansourian, Peter C. Burgers, Bahareh Amin, Mahmoud Reza Jaafari, Timo L. M. ten Hagen   +5 more
doaj   +1 more source

Tumour vessel remodelling: new opportunities in cancer treatment

Vascular Biology, 2020
Tumour growth critically depends on a supportive microenvironment, including the tumour vasculature. Tumour blood vessels are structurally abnormal and functionally anergic which limits drug access and immune responses in solid cancers.
Ruth Ganss
doaj   +1 more source

Light-enhanced VEGF121/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment

Frontiers in Immunology, 2023
BackgroundImmune-checkpoint inhibitors (ICIs) represent a revolution in cancer therapy and are currently implemented as standard therapy within several cancer indications.
Ane Sager Longva, Kristian Berg, Anette Weyergang   +2 more
doaj   +1 more source

Targeting Epigenetic Mechanisms in Vascular Aging

Frontiers in Cardiovascular Medicine, 2022
Environment, diseases, lack of exercise, and aged tendency of population have becoming crucial factors that induce vascular aging. Vascular aging is unmodifiable risk factor for diseases like diabetes, hypertension, atherosclerosis, and hyperlipidemia ...
Zhongxiao Lin, Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu, YiZhun Zhu   +8 more
doaj   +1 more source

Coupling and robustness of intra-cortical vascular territories [PDF]

, 2012
Vascular domains have been described as being coupled to neuronal functional units enabling dynamic blood supply to the cerebral cyto-architecture. Recent experiments have shown that penetrating arterioles of the grey matter are the building blocks for ...
Plouraboué, Franck, Guibert, Romain, Risser, Laurent, Fonta, Caroline   +3 more
core   +1 more source

Intratumoral LIGHT Restores Pericyte Contractile Properties and Vessel Integrity

Cell Reports, 2015
Normalization of the tumor vasculature is an emerging concept shown to improve anti-cancer therapy. However, there are currently no clinical interventions that effect long-lasting normalization.
Anna Johansson-Percival, Zhi-Jie Li, Devina D. Lakhiani, Bo He, Xiao Wang, Juliana Hamzah, Ruth Ganss   +6 more
doaj   +1 more source

Diffusion-Weighted Magnetic Resonance Imaging Allows Noninvasive In Vivo Monitoring of the Effects of Combretastatin A-4 Phosphate after Repeated Administration

Neoplasia: An International Journal for Oncology Research, 2005
The noninvasive assessment of anticancer treatment efficacy is very important for the improvement of therapeutic window. The purpose of the present study was to evaluate the antitumoral effects of the vascular targeting agent, combretastatin A-4 ...
Harriet C. Thoeny, Frederik De Keyzer, Feng Chen, Vincent Vandecaveye, Erik K. Verbeken, Bisan Ahmed, Xihe Sun, Yicheng Ni, Hilde Bosmans, Robert Hermans, Allan van Oosterom, Guy Marchal, Willy Landuyt   +12 more
doaj   +1 more source

Radiotherapy in combination with vascular-targeted therapies [PDF]

Radiology and Oncology, 2010
Given the critical role of tumor vasculature in tumor development, considerable efforts have been spent on developing therapeutic strategies targeting the tumor vascular network. A variety of agents have been developed, with two general approaches being pursued.
Ćirić, Eva, Serša, Gregor
openaire   +4 more sources

Targeting tumor vasculature [PDF]

, 2009
Targeting tumor vasculature is the common theme for the three separate studies presented in this thesis. The studies comprise the roles of components of three signaling pathways (networks) in several steps of blood vessel formation, and related tumor ...
Samaržija, Ivana
core   +1 more source

Rat Tumor Response to the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid as Measured by Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Plasma 5-Hydroxyindoleacetic Acid Levels, and Tumor Necrosis

Neoplasia: An International Journal for Oncology Research, 2006
The dose-dependent effects of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) on rat GH3 prolactinomas were investigated in vivo. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used to assess tumor blood flow/permeability pretreatment ...
Lesley D. McPhail, Dominick J.O. McIntyre, Christian Ludwig, Philip Kestell, John R. Griffiths, Lloyd R. Kelland, Simon P. Robinson   +6 more
doaj   +1 more source