Results 31 to 40 of about 1,860,910 (290)

Recent advances of nanotechnology-based tumor vessel-targeting strategies

Journal of Nanobiotechnology, 2021
Tumor vessels can provide oxygen and nutrition for solid tumor tissue, create abnormal tumor microenvironment (TME), and play a vital role in the development, immune escape, metastasis and drug resistance of tumor.
Dongjie Zhu, Yang Li, Zhengjia Zhang, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Ting Zhao, Cheng Lu, Yuanyan Liu   +8 more
doaj   +1 more source

The Vascular-Targeting Fusion Toxin VEGF121/rGel Inhibits the Growth of Orthotopic Human Bladder Carcinoma Tumors

Neoplasia: An International Journal for Oncology Research, 2005
Vascular endothelial growth factor. (VEGF) and its receptors. (FLT-1 and KDR) are overexpressed by human bladder cancer cells and tumor endothelial cells, respectively.
Khalid Mohamedali, Daniel Kedar, Paul Sweeney, Ashish Kamat, Darren W. Davis, Beryl Y. Eve, Samuel Huang, Philip E. Thorpe, Colin P. Dinney, Michael G. Rosenblum   +9 more
doaj   +1 more source

The Microtubule-Targeting Agent Pretubulysin Impairs the Inflammatory Response in Endothelial Cells by a JNK-Dependent Deregulation of the Histone Acetyltransferase Brd4

Cells, 2023
The anti-inflammatory effects of depolymerizing microtubule-targeting agents on leukocytes are known for a long time, but the potential involvement of the vascular endothelium and the underlying mechanistic basis is still largely unclear.
Tobias F. Primke, Rebecca Ingelfinger, Mohammed A. F. Elewa, Igor Macinkovic, Andreas Weigert, Matthias P. Fabritius, Christoph A. Reichel, Angelika Ullrich, Uli Kazmaier, Luisa D. Burgers, Robert Fürst   +10 more
doaj   +1 more source

Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin

eLife, 2020
Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include ...
Ross O Smith, Takeshi Ninchoji, Emma Gordon, Helder André, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh   +7 more
doaj   +1 more source

Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study

Frontiers in Pharmacology, 2023
Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong, Li Ping Wong, Haridah Alias, Kit Mun Tan, Pooi Fong Wong, Dharmani Devi Murugan, Zhijian Hu, Yulan Lin   +7 more
doaj   +1 more source

The Collaborative Big Bang and Introduction to the European Vascular Research Collaborative.

, 2022
2European Vascular Research Collaborative: Salome ...
European Vascular Research, Collaborative, Meecham, Lewis   +1 more
core   +1 more source

Targeting of Tumor Neovasculature with GrB/VEGF121, a Novel Cytotoxic Fusion Protein

Biomedicines, 2017
Angiogenesis is a critical process in numerous diseases, and intervention in neovascularization has therapeutic value in several disease settings, including ocular diseases, arthritis, and in tumor progression and metastatic spread.
Khalid A. Mohamedali, Michael G. Rosenblum   +1 more
doaj   +1 more source

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Photoacoustics, 2022
Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse and progression. This study aimed to develop a new technological platform for the visualization of small and flat urothelial lesions of high-grade ...
Elisa Alchera, Matteo Monieri, Mirko Maturi, Irene Locatelli, Erica Locatelli, Silvia Tortorella, Angelina Sacchi, Angelo Corti, Manuela Nebuloni, Roberta Lucianò, Filippo Pederzoli, Francesco Montorsi, Andrea Salonia, Sandra Meyer, Jithin Jose, Pierangela Giustetto, Mauro Comes Franchini, Flavio Curnis, Massimo Alfano   +18 more
doaj   +1 more source

Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcoichinol-O-Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model

Neoplasia: An International Journal for Oncology Research, 2004
Tumor vasculature is an attractive therapeutic target as it differs structurally from normal vasculature, and the destruction of a single vessel can lead to the death of many tumor cells.
Dominick J.O. McIntyre, Simon P. Robinson, Franklyn A. Howe, John R. Griffiths, Anderson J. Ryan, David C. Blakey, Ian S. Peers, John C. Waterton   +7 more
doaj   +1 more source

Multimodal imaging of breast cancer metastasis targeting and antimetastatic nanotherapy [PDF]

, 2016
INTRODUCTION: As opposed to the routine use of nanomedicines for drug targeting to solid tumors, the highest medical need refers to targeting and treating metastasis.
Rijcken, Cristianne, Kiessling, Fabian, Pola, Robert, Chemical Biology and Drug Discovery, Lammers, Twan, Ehling, Josef, Sub Drug targeting, Sub General Pharmaceutics, Storm, G, Von Stillfried, Saskia, Rizzo, Larissa   +10 more
core   +2 more sources