Results 81 to 90 of about 7,952,783 (243)

Targeting cancer stem cell pathways for cancer therapy

Signal Transduction and Targeted Therapy, 2020
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been considered promising therapeutic targets for cancer therapy. These cells have self-renewal capacity and differentiation potential and contribute to multiple tumor ...
Liqun Yang, Pengfei Shi, Gaichao Zhao, Jie Xu, Wen Peng, Jiayi Zhang, Guanghui Zhang, Xiaowen Wang, Z. Dong, Fei Chen, H. Cui   +10 more
semanticscholar   +1 more source

Targeting β1-integrin inhibits vascular leakage in endotoxemia

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Compromised vascular integrity is associated with capillary leakage in sepsis, but effective therapies stabilizing the vasculature are lacking.
Laura Hakanpaa, E. A. Kiss, Guillaume Jacquemet, I. Miinalainen, Martina Lerche, Camilo Guzmán, E. Mervaala, L. Eklund, J. Ivaska, P. Saharinen   +9 more
semanticscholar   +1 more source

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Asian Journal of Pharmaceutical Sciences, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan Wang   +4 more
doaj   +1 more source

Tumor Delivery of Chemotherapy Combined with Inhibitors of Angiogenesis and Vascular Targeting Agents

Frontiers in Oncology, 2013
Numerous angiogenesis-vascular targeting agents have been admitted to the ranks of cancer therapeutics; most are used in polytherapy regimens. This review looks at recent progress and our own preclinical experience in combining angiogenesis inhibitors ...
M. Cesca, Francesca Bizzaro, M. Zucchetti, R. Giavazzi   +3 more
semanticscholar   +1 more source

Targeting Vascular Stiffness

Arteriosclerosis, Thrombosis, and Vascular Biology
Artery stiffening, a biomechanical vascular property closely related to but separate from hypertension, is a strong and independent cardiovascular disease risk factor that also predicts end-organ failure. Decreased aortic compliance elevates the mechanical load on the myocardium, increases peripheral pulse pressure which damages high-flow organs ...
openaire   +2 more sources

Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 [PDF]

, 2018
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined.
Chen, Jiwang, Comhair, Suzy, Machado, Roberto F., Natarajan, Viswanathan, Singla, Sunit, Sysol, Justin R., Zhao, Shuangping   +6 more
core   +1 more source

Targeting Tumor Vascular CD99 Inhibits Tumor Growth

Frontiers in Immunology, 2019
CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker
Elisabeth J. M. Huijbers, Inge M. van der Werf, Lisette D. Faber, Lena D. Sialino, Pia van der Laan, Hanna A. Holland, Anca M. Cimpean, Victor L. J. L. Thijssen, Judy R. van Beijnum, Arjan W. Griffioen   +9 more
doaj   +1 more source

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth

Journal of Pathology, 2018
Aggressive tumor cells can adopt an endothelial cell‐like phenotype and contribute to the formation of a tumor vasculature, independent of tumor angiogenesis.
V. Thijssen, Y. Paulis, P. Nowak‐Sliwinska, Katrin Deumelandt, K. Hosaka, P. Soetekouw, A. Cîmpean, M. Raica, P. Pauwels, J. J. van den Oord, V. Tjan-Heijnen, M. Hendrix, C. Heldin, Yihai Cao, A. Griffioen   +14 more
semanticscholar   +1 more source

Circulating micrornas associated with glycemic impairment and progression in Asian Indians. [PDF]

, 2015
Aims/hypothesisAsian Indians have a high incidence of type 2 diabetes, but factors associated with glycemic progression in this population are not understood.
Aouizerat, Bradley E, Flowers, Elena, Gadgil, Meghana, Kanaya, Alka M   +3 more
core   +1 more source

Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]

, 2018
Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core