Results 41 to 50 of about 463,789 (285)
Role of innate immune cells in multiple sclerosis
Frontiers in ImmunologyMultiple sclerosis (MS) is a chronic autoimmune, inflammatory and neurodegenerative disease affecting the central nervous system (CNS). MS is associated with a complex interplay between neurodegenerative and inflammatory processes, mostly attributed to ...
Carolina Prado +5 more
doaj +1 more source
Numerical simulation of solid tumor blood perfusion and drug delivery during the “vascular normalization window” with antiangiogenic therapy [PDF]
, 2011 This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2011 Hindawi PublishingTo investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network ...
Cai, Y +6 more
core +2 more sources
Carbonic anhydrase, its inhibitors and vascular function
Frontiers in Molecular BiosciencesIt has been known for some time that Carbonic Anhydrase (CA, EC 4.2.1.1) plays a complex role in vascular function, and in the regulation of vascular tone.
Andrea García-Llorca +4 more
doaj +1 more source
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor [PDF]
, 2019 Ovarian cancer is the fifth leading cause of cancer-related deaths in women. In the past 20 years, the canonical types of drugs used to treat ovarian cancer have not been replaced and the survival rates have not changed.
Abramovich, Dalhia Nurit +7 more
core +1 more source
The Horizontal Raphe of the Human Retina and its Watershed Zones
Vision, 2019 The horizontal raphe (HR) as a demarcation line dividing the retina and choroid into separate vascular hemispheres is well established, but its development has never been discussed in the context of new findings of the last decades.
Christian Albrecht May, Paul Rutkowski
doaj +1 more source
The Vasculature in Prediabetes [PDF]
Circulation Research, 2018 The frequency of prediabetes is increasing as the prevalence of obesity rises worldwide. In prediabetes, hyperglycemia, insulin resistance, and inflammation and metabolic derangements associated with concomitant obesity cause endothelial vasodilator and fibrinolytic dysfunction, leading to increased risk of cardiovascular and renal disease. Importantly,
David H, Wasserman +2 more
openaire +2 more sources
Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]
, 2013 Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Abdominal Wall Vascular Injury by Drain Insertion After Anterior Lumbar Spinal Fusion
Journal of Orthopaedics, Trauma and Rehabilitation, 2016 A 64-year-old gentleman presented with haemoglobin drop and an increase in fresh blood output in abdominal drain after anterior lumbar spinal fusion. Urgent re-exploration was performed, and injury to abdominal wall vessel during drain insertion leading ...
Wai Kit Ng, Tun Hing Lui, Wai Kit Ngai
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source