Results 21 to 30 of about 22,615 (195)

Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy

Nature Communications, 2021
Stroke profoundly disrupts cortical excitability which impedes recovery, but how stroke affects inhibitory interneurons is poorly understood. Here, the authors show that functional impairments after stroke are associated with the disruption of a highly ...
Mohamad Motaharinia, Kim Gerrow, Roobina Boghozian, Emily White, Sun-Eui Choi, Kerry R. Delaney, Craig E. Brown   +6 more
doaj   +1 more source

Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma

Nature Communications, 2022
Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling ...
Sruthi Ravindranathan, Tenzin Passang, Jian-Ming Li, Shuhua Wang, Rohan Dhamsania, Michael Brandon Ware, Mohammad Y. Zaidi, Jingru Zhu, Maria Cardenas, Yuan Liu, Sanjeev Gumber, Brian Robinson, Anish Sen-Majumdar, Hanwen Zhang, Shanmuganathan Chandrakasan, Haydn Kissick, Alan B. Frey, Susan N. Thomas, Bassel F. El-Rayes, Gregory B. Lesinski, Edmund K. Waller   +20 more
doaj   +1 more source

Enhanced Mortality to Metastatic Bladder Cancer Cell Line MB49 in Vasoactive Intestinal Peptide Gene Knockout Mice

Frontiers in Endocrinology, 2017
To identify if the absence of the vasoactive intestinal peptide (VIP) gene enhances susceptibility to death from metastatic bladder cancer, two strains of mice were injected with MB49 murine bladder cancer cells.
Niely Mirsaidi, Niely Mirsaidi, Matthew P. Burns, Matthew P. Burns, Steve A. McClain, Edward Forsyth, Jonathan Li, Jonathan Li, Brittany Dukes, Brittany Dukes, David Lin, David Lin, Roxanna Nahvi, Roxanna Nahvi, Jheison Giraldo, Jheison Giraldo, Megan Patton, Ping Wang, Ke Lin, Edmund Miller, Edmund Miller, Edmund Miller, Timothy Ratliff, Timothy Ratliff, Sayyed Hamidi, Scott Crist, Scott Crist, Ken-Ichi Takemaru, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema   +33 more
doaj   +1 more source

Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

Frontiers in Pharmacology, 2021
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established.
Kotaro Sakamoto, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Kenji Ishimoto, Kenji Ishimoto, Nobumasa Hino, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Satoshi Asano, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +16 more
doaj   +1 more source

Calcitonin Gene-Related Peptide (CGRP) in Cerebrovascular Disease

The Scientific World Journal, 2002
Cerebral blood vessels are innervated by sensory nerves that store several neurotransmitters among which calcitonin gene-related peptide (CGRP) is the most abundant. In primary headaches, there is a clear association between the head pain and the release
Lars Edvinsson
doaj   +1 more source

Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

Nature Communications, 2018
Long-range GABAergic hippocampal neurons project to cortical and subcortical areas, while vasoactive intestinal peptide (VIP+) interneurons can inhibit other GABAergic neurons.
Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi, Lisa Topolnik   +9 more
doaj   +1 more source

Select cognitive deficits in Vasoactive Intestinal Peptide deficient mice

BMC Neuroscience, 2008
Background The neuropeptide vasoactive intestinal peptide (VIP) is widely distributed in the adult central nervous system where this peptide functions to regulate synaptic transmission and neural excitability.
Hagopian Arkady, Dragich Joanna M, Loh Dawn H, Chaudhury Dipesh, Colwell Christopher S   +4 more
doaj   +1 more source

Effect of Da Vinci Robot Radical Gastrectomy on Gastrointestinal Motility and Gastrointestinal Hormones of Gastric Cancer Patients

Zhongliu Fangzhi Yanjiu, 2019
Objective To investigate the effect of Da Vinci robot radical gastrectomy on gastrointestinal motility and hormones of gastric cancer patients. Methods We selected 217 patients who underwent radical gastrectomy.
HAN Boqiang, MA Youwei, ZHANG Cheng, ZHOU Dangjun, LIU Hongbin, HAN Xiaopeng   +5 more
doaj   +1 more source

Pheochromocytoma Producing Vasoactive Intestinal Peptide [PDF]

Mayo Clinic Proceedings, 2002
The syndrome of watery diarrhea associated with hypokalemia and achlorhydria was originally described in 1958. Subsequently, this syndrome was shown to be caused by a neuroendocrine tumor secreting vasoactive intestinal peptide (VIP), and such tumors are almost always pancreatic in origin.
Stephen L, Smith, A L Jackson, Slappy, Thomas P, Fox, James S, Scolapio   +3 more
openaire   +2 more sources

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source