Results 31 to 40 of about 920,092 (279)

Development by Genetic Immunization of Monovalent Antibodies Against Human Vasoactive Intestinal Peptide Receptor 1 (VPAC1), New Innovative, and Versatile Tools to Study VPAC1 Receptor Function

Frontiers in Endocrinology, 2018
Multi-membrane spanning proteins, such as G protein-coupled receptors (GPCRs) and ion channels, are extremely difficult to purify as native proteins. Consequently, the generation of antibodies that recognize the native conformation can be challenging. By
Xavier Peyrassol, Toon Laeremans, Toon Laeremans, Toon Laeremans, Vannessa Lahura, Maja Debulpaep, Maja Debulpaep, Maja Debulpaep, Hassan El Hassan, Hassan El Hassan, Hassan El Hassan, Jan Steyaert, Jan Steyaert, Marc Parmentier, Marc Parmentier, Ingrid Langer   +15 more
doaj   +1 more source

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Nature Communications, 2022
Vasoactive intestinal polypeptide receptor 2 (VIP2R) is involved in immunity. Here, the authors report two cryo-EM structures of the VIP2R–Gs in complex with the endogenous peptide ligand PACAP27, revealing a unique interaction mode between PACAP27 and ...
Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Li-Hua Zhao, Tian Xia, Yi Jiang, H. Eric Xu, Dehua Yang, Ming-Wei Wang   +15 more
doaj   +1 more source

Screening of a specific peptide binding to VPAC1 receptor from a phage display peptide library. [PDF]

PLoS ONE, 2013
BACKGROUND/PURPOSE: The VPAC1 receptor, a member of the vasoactive intestinal peptide receptors (VIPRs), is overexpressed in the most frequently occurring malignant tumors and plays a major role in the progression and angiogenesis of a number of ...
Bo Tang, Zhexu Li, Dingde Huang, Lei Zheng, Qianwei Li   +4 more
doaj   +1 more source

Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival.

American Journal of Pathology, 2018
Corneal transplantation is the most prevalent form of tissue transplantation. The success of corneal transplantation mainly relies on the integrity of corneal endothelial cells (CEnCs), which maintain graft transparency.
Vannarut Satitpitakul, Zhongmou Sun, Kunal Suri, A. Amouzegar, K. Katikireddy, U. Jurkunas, A. Kheirkhah, R. Dana   +7 more
semanticscholar   +1 more source

Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy

Nature Communications, 2021
Stroke profoundly disrupts cortical excitability which impedes recovery, but how stroke affects inhibitory interneurons is poorly understood. Here, the authors show that functional impairments after stroke are associated with the disruption of a highly ...
Mohamad Motaharinia, Kim Gerrow, Roobina Boghozian, Emily White, Sun-Eui Choi, Kerry R. Delaney, Craig E. Brown   +6 more
doaj   +1 more source

Enhanced Mortality to Metastatic Bladder Cancer Cell Line MB49 in Vasoactive Intestinal Peptide Gene Knockout Mice

Frontiers in Endocrinology, 2017
To identify if the absence of the vasoactive intestinal peptide (VIP) gene enhances susceptibility to death from metastatic bladder cancer, two strains of mice were injected with MB49 murine bladder cancer cells.
Niely Mirsaidi, Niely Mirsaidi, Matthew P. Burns, Matthew P. Burns, Steve A. McClain, Edward Forsyth, Jonathan Li, Jonathan Li, Brittany Dukes, Brittany Dukes, David Lin, David Lin, Roxanna Nahvi, Roxanna Nahvi, Jheison Giraldo, Jheison Giraldo, Megan Patton, Ping Wang, Ke Lin, Edmund Miller, Edmund Miller, Edmund Miller, Timothy Ratliff, Timothy Ratliff, Sayyed Hamidi, Scott Crist, Scott Crist, Ken-Ichi Takemaru, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema, Anthony Szema   +33 more
doaj   +1 more source

Generation of KS-133 as a Novel Bicyclic Peptide with a Potent and Selective VIPR2 Antagonist Activity that Counteracts Cognitive Decline in a Mouse Model of Psychiatric Disorders

Frontiers in Pharmacology, 2021
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established.
Kotaro Sakamoto, Lu Chen, Tatsunori Miyaoka, Mei Yamada, Teruaki Masutani, Kenji Ishimoto, Kenji Ishimoto, Kenji Ishimoto, Nobumasa Hino, Shinsaku Nakagawa, Shinsaku Nakagawa, Shinsaku Nakagawa, Satoshi Asano, Yukio Ago, Yukio Ago, Yukio Ago, Yukio Ago   +16 more
doaj   +1 more source

Calcitonin Gene-Related Peptide (CGRP) in Cerebrovascular Disease

The Scientific World Journal, 2002
Cerebral blood vessels are innervated by sensory nerves that store several neurotransmitters among which calcitonin gene-related peptide (CGRP) is the most abundant. In primary headaches, there is a clear association between the head pain and the release
Lars Edvinsson
doaj   +1 more source

Therapeutic Efficacy of Stable Analogues of Vasoactive Intestinal Peptide against Pathogens*

Journal of Biological Chemistry, 2014
Background: Antimicrobial properties of the anti-inflammatory neuropeptide VIP are limited by its unstable nature. Results: The VIP derivatives protected against polymicrobial sepsis and cutaneous leishmaniasis by selectively killing pathogens through ...
J. Campos-Salinas, A. Cavazzuti, F. O'Valle, I. Forte-Lago, M. Caro, S. Beverley, M. Delgado, E. González-Rey   +7 more
semanticscholar   +1 more source

Connectivity and network state-dependent recruitment of long-range VIP-GABAergic neurons in the mouse hippocampus

Nature Communications, 2018
Long-range GABAergic hippocampal neurons project to cortical and subcortical areas, while vasoactive intestinal peptide (VIP+) interneurons can inhibit other GABAergic neurons.
Ruggiero Francavilla, Vincent Villette, Xiao Luo, Simon Chamberland, Einer Muñoz-Pino, Olivier Camiré, Kristina Wagner, Viktor Kis, Peter Somogyi, Lisa Topolnik   +9 more
doaj   +1 more source