Results 201 to 210 of about 9,502 (211)

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

The FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Effect of erenumab versus other migraine preventive medications on cardiovascular and cerebrovascular outcomes: A United States claims database‐based observational cohort study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective To estimate the real‐world risk of cardiovascular events among patients with migraine treated with erenumab and other migraine preventive medications. Background Migraine preventive treatment with calcitonin gene‐related peptide (CGRP) pathway inhibitors, such as erenumab and others, may theoretically result in cardiovascular effects
David W. Dodick, Stewart J. Tepper, Jessica Ailani, Ani C. Khodavirdi, Nico Pannacciulli, Alan Fu, Shia T. Kent, Karminder Gill, Robert Urman, Sam S. Oh   +9 more
wiley   +1 more source

Development and pharmacological characterization of novel multi‐ calcitonin gene‐related peptide and pituitary adenylate cyclase‐activating peptide receptor antagonists

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objective This study aimed to provide proof‐of‐concept that multi‐receptor antagonist peptides can be generated by covalently linking independent antagonist peptides that block calcitonin gene‐related peptide (CGRP8‐37) or pituitary adenylate cyclase‐activating peptide (PACAP)/vasoactive intestinal peptide (VIP) (PACAP6‐38) activity ...
Zoe Tasma, Andrew Siow, Paul W. R. Harris, Margaret A. Brimble, Debbie L. Hay, Christopher S. Walker   +5 more
wiley   +1 more source

Short-Term Estrogen Augments Both Nitric Oxide-Mediated and Non-Nitric Oxide-Mediated Endothelium-Dependent Forearm Vasodilation in Postmenopausal Women

, 1997
Hirofumi Tagawa, Hiroaki Shimokawa, Tatsuya Tagawa, Mari Kuroiwa‐Matsumoto, Yoshitaka Hirooka, Akira Takeshita   +5 more
openalex   +1 more source

Type 2 Inflammation and Its Role in Dermatologic Diseases

International Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis, prurigo nodularis, and chronic spontaneous urticaria are immune‐mediated, inflammatory skin conditions characterized by intense itch and disease‐specific skin lesions. Despite their different clinical presentations, the three diseases are unified by an aberrant type 2 immune response involving type 2 cytokines, immune cells,
Raj Chovatiya, Jason E. Hawkes, Douglas DiRuggiero, Leigh Ann Pansch, Elizabeth Simcox, Tayler Gonzalez   +5 more
wiley   +1 more source

Ceratonia siliqua Protects Testicular Tissue in Ischemia/Reperfusion Injury

International Journal of Urology, EarlyView.
ABSTRACT Objectives Testicular torsion is a urological emergency with a risk of resulting in loss of testicular function due to ischemia/reperfusion injury (I/R) injury caused by oxidative stress. Ceratonia siliqua is known to decrease oxidative stress in urological pathologies. We investigated the protective effects of C.
Şahika Yardim, Murat Dursun, İlayda Sözmen, Abdurrahman Fatih Aydin, Ateş Kadioğlu, Ünal Uslu, Elif Kervancioğlu Demirci   +6 more
wiley   +1 more source

The Synergetic Effect of Periodontal Therapy and TNF‐α Inhibitor for the Treatment of Comorbid Periodontitis and Psoriasis

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To assess the adjunctive effect of periodontal therapy on psoriasis‐related outcomes in a combined experimental model of ligature‐induced periodontitis and Imiquimod (IMQ)‐induced psoriasis. Also, this experiment aimed to study the impact of TNF‐α inhibitors on the periodontium.
Crystal Marruganti, Carlo Gaeta, Chiara Falciani, Elisa Cinotti, Pietro Rubegni, Mario Alovisi, Nicola Scotti, Andrea Baldi, Cristiana Bellan, Chiara Defraia, Elena Bertaggia, Fabio Fiorino, Silvia Valensin, Erika Bellini, Antonella De Rosa, Filippo Graziani, Francesco D'Aiuto, Simone Grandini   +17 more
wiley   +1 more source

Revisiting the thrifty substrate hypothesis: Ketone bodies as cardioprotective fuels in diabetes and SGLT2 inhibitor therapy

Journal of Diabetes Investigation, EarlyView.
SGLT2 inhibitors increase circulating β‐hydroxybutyrate (β‐OH‐B), a ketone body that may enhance cardiac efficiency in HFrEF. The “thrifty substrate hypothesis” suggests β‐OH‐B provides more ATP per oxygen consumed than glucose or fatty acids. Clinical studies by Nielsen et al. and Solis‐Herrera et al. show that β‐OH‐B infusion improves cardiac output,
Yoriyasu Suzuki, Tetsuya Amano
wiley   +1 more source

Erectile dysfunction in dermatology and venereology: From aetiopathogenic mechanisms to practical considerations for dermato‐venereologists

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Multiple inflammatory, infectious and autoimmune dermato‐venereological conditions are associated with erectile dysfunction (ED) due to underlying intricate vasculogenic, neurogenic, endocrine and psychogenic mechanisms. It is recommended that practitioners screen dermatology patients for ED and associated comorbidities, provide personalized lifestyle ...
Andrei Tanasov, George‐Sorin Tiplica
wiley   +1 more source

Skin development in the gray short‐tailed opossum (Monodelphis domestica)—From skin respiration to thermoregulation

Journal of Anatomy, EarlyView.
The skin development in the gray short‐tailed opossum (Monodelphis domestica) has been examined using histological, morphometric, and μCT methods. During a long period of postnatal development, the structural differentiation of the skin results in a functional shift from transcutaneous gas exchange to thermoregulation in later life. Abstract Marsupials
Kirsten Ferner
wiley   +1 more source