Results 201 to 210 of about 204,625 (386)

Sphingosine‐1‐Phosphate Receptor Modulators for the Treatment of Ulcerative Colitis: A Narrative Review Focusing on Safety

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Ulcerative colitis is a chronic immune‐mediated inflammatory disease of the colon that causes considerable morbidity and increases the risk of colorectal cancer. Several targeted therapies have been developed for moderate‐to‐severe ulcerative colitis, significantly improving its management.
Massimo C. Fantini   +4 more
wiley   +1 more source

Impaired Endothelium‐Dependent Vasodilation in Patients With Insulin‐Dependent Diabetes Mellitus

open access: yesCirculation, 1993
M. Johnstone   +5 more
semanticscholar   +1 more source

Heat Stress and Placental Abruption: A Space–Time Stratified Case‐Crossover Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To examine whether heat stress, measured by wet bulb globe temperature (WBGT), a comprehensive heat stress index is associated with placental abruption within 7 days. Design A space–time‐stratified case‐crossover design. Setting All 11 regions in Japan during the warm season (June–September) from 2011 to 2020.
Shuhei Terada   +3 more
wiley   +1 more source

Vasodilation by Medroxalol Mediated by β2-Adrenergic Receptor Stimulation

open access: bronze, 1983
Richard C. Dage   +2 more
openalex   +1 more source

Impaired endothelium-dependent and independent vasodilation in patients with Type 2 (non-insulin-dependent) diabetes mellitus [PDF]

open access: bronze, 1992
Gary E. McVeigh   +7 more
openalex   +1 more source

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

open access: yesAging Cell, EarlyView.
This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante   +24 more
wiley   +1 more source

Regular Aerobic Exercise Prevents and Restores Age-Related Declines in Endothelium-Dependent Vasodilation in Healthy Men

open access: yesCirculation, 2000
C. Desouza   +6 more
semanticscholar   +1 more source

Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice

open access: yesAging Cell, EarlyView.
Senolytic therapy restores neurovascular function, blood–brain barrier integrity, and cognitive performance in aged mice by targeting endothelial senescence. Findings highlight that brain microvascular endothelial cells are highly vulnerable to aging‐induced senescence, and early intervention in middle age may be the most effective strategy to prevent ...
Boglarka Csik   +20 more
wiley   +1 more source

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