Results 211 to 220 of about 204,625 (386)

Dietary Restriction Mitigates Vascular Aging, Modulates the cGAS‐STING Pathway and Reverses Macrophage‐Like VSMC Phenotypes in Progeroid DNA‐Repair‐Deficient Ercc1Δ/− Mice

open access: yesAging Cell, EarlyView.
Dietary restriction mitigates vascular aging in DNA‐repair‐deficient Ercc1Δ/− mice by reducing extracellular matrix remodeling, inflammation, oxidative stress, and switching of vascular smooth muscle cells to a macrophage‐like phenotype. Our findings suggest that the cGAS‐STING pathway plays a key role in vascular aging and that the benefits of dietary
S. J. M. Stefens   +14 more
wiley   +1 more source

β-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia. [PDF]

open access: yesAm J Physiol Heart Circ Physiol
Jacob DW   +8 more
europepmc   +1 more source

BubR1 Insufficiency Drives Transcriptomic Alterations and Pathology Associated With Cardiac Aging and Heart Failure

open access: yesAging Cell, EarlyView.
Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun   +13 more
wiley   +1 more source

Suppression of insulin-induced sympathetic activation and vasodilation by dexamethasone in humans. [PDF]

open access: bronze, 1993
Urs Scherrer   +5 more
openalex   +1 more source

Treatment of Early‐Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Bipolar disorder (BD), characterized by extreme mood shifts between mania and depression, can manifest in childhood, and pose treatment challenges. Treatment for full‐criteria BD I or II in children has been partially described in the literature, but major uncertainties exist regarding non‐classic presentations, which were ...
Demitri F. Papolos   +2 more
wiley   +1 more source

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