Results 61 to 70 of about 204,625 (386)

Gel-forming antagonist provides a lasting effect on CGRP-induced vasodilation

Frontiers in Pharmacology, 2022
Migraine affects ∼15% of the adult population, and the standard treatment includes the use of triptans, ergotamines, and analgesics. Recently, CGRP and its receptor, the CLR/RAMP1 receptor complex, have been targeted for migraine treatment due to their ...
Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu   +2 more
doaj   +1 more source

Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]

, 2004
<p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C., Harazny, J., Hilgers, K.F., Michelson, G., Oehmer, S., Schmieder, R.E.   +5 more
core   +1 more source

In vivo Stimulus-Induced Vasodilation Occurs without IP3 Receptor Activation and May Precede Astrocytic Calcium Increase

Journal of Neuroscience, 2013
Calcium-dependent release of vasoactive gliotransmitters is widely assumed to trigger vasodilation associated with rapid increases in neuronal activity. Inconsistent with this hypothesis, intact stimulus-induced vasodilation was observed in inositol 1,4 ...
Krystal Nizar, Hana Uhlířová, Peifang A. Tian, P. Saisan, Qun Cheng, L. Reznichenko, Kimberly L. Weldy, Tyler C. Steed, Vishnu B. Sridhar, Christopher L. MacDonald, Jianxia Cui, Sergey L. Gratiy, S. Sakadžić, D. Boas, T. I. Beka, G. Einevoll, Ju Chen, E. Masliah, A. Dale, G. Silva, A. Devor   +20 more
semanticscholar   +1 more source

Rational Design of Metal–Organic Frameworks for Pancreatic Cancer Therapy: from Machine Learning Screening to In Vivo Efficacy

Advanced Materials, EarlyView.
This work explores the MOF landscape to select a single, optimal candidate for successfully delivering cancer drugs (gemcitabine, paclitaxel, SN‐38) into tough pancreatic tumors. Machine learning and simulations guide this search, demonstrating colloidal stability, excellent biocompatibility, cellular uptake, and sustained release.
Francesca Melle, Dhruv Menon, João Conniot, Jon Ostolaza‐Paraiso, Sergio Mercado, Jhenifer Oliveira, Xu Chen, Bárbara B. Mendes, João Conde, David Fairen‐Jimenez   +9 more
wiley   +1 more source

Skeletal Muscle Hyperemia: A Potential Bridge Between Post-exercise Hypotension and Glucose Regulation

Frontiers in Physiology, 2022
For both healthy individuals and patients with type 2 diabetes (T2D), the hemodynamic response to regular physical activity is important for regulating blood glucose, protecting vascular function, and reducing the risk of cardiovascular disease.
Thomas K. Pellinger, Chi-An W. Emhoff
doaj   +1 more source

Examining the role of insulin in the regulation of cardiovascular health [PDF]

, 2013
A substantial body of evidence has reported that insulin has direct actions on the cardiovascular system independent of its systemic effects on plasma glucose or lipids.
Salt, Ian P.
core   +1 more source

A Highly Adaptable Hydrogen Bond Re‐Orientation (HyBRO) Strategy for Multiscale Vasculature Fabrication

Advanced Materials, EarlyView.
A novel hydrogen bond re‐orientation (HyBRO) strategy enables three‐dimensional (3D) printing of vascular microchannel networks with high accuracy. By switching sacrificial material interactions with nonsolvents, HyBRO prevents swelling and deformation, enabling accurate hierarchical channels spanning a tenfold size range.
Zhencheng Liao, Yu Liu, Chonghao Chen, Iek Man Lei, Lei Dong, Chunming Wang   +5 more
wiley   +1 more source

Nanostructured 316L Stainless Steel Stent Surfaces Improve Corrosion Resistance, and Enhance Endothelization and Hemocompatibility

Advanced Materials Interfaces, EarlyView.
This study investigates the impact of nanostructured surface modification on corrosion resistance, HUVEC functions, and platelet interactions of 316L SS for cardiovascular stents. Nanostructured surfaces enhanced HUVEC proliferation, migration, and angiogenesis‐related gene expression while reducing platelet adhesion and hemolysis.
Yasar Kemal Erdogan, Pelin Mutlu, Batur Ercan   +2 more
wiley   +1 more source

Differential effects of EPA vs. DHA on postprandial vascular function and the plasma oxylipin profile in men [PDF]

, 2016
Our objective was to investigate the impact of EPA versus DHA, on arterial stiffness and reactivity, and underlying mechanisms (with a focus on plasma oxylipins), in the postprandial state.
Aedin Cassidy, Anne Marie Minihane, Armah, Asmar, Balakumar, Berry, Bonetti, Chong, Conquer, David Vauzour, Feelisch, Fischer, Flammer, Frömel, Hallund, Hickson, Huang, Ingrid Fleming, Jackson, Janner, Janner, Khader Awwad, Lauer, Lind, Lithander, Macready, Martin, Michaelis, Miller, Mitchell, Moerland, Mori, Morin, Morin, Mozaffarian, Mozaffarian, Mustafa, Neil Rigby, Noemi Tejera, Nürnberger, Pase, Psychogios, Pucci, Purcell, Ras, Rontoyanni, Ruiz-Lopez, Salem, Saravanan, Schebb, Schächinger, Seán McManus, Shearer, Shearer, Shen, Siasos, Strassburg, Vauzour, Vlachopoulos, Wang, Wang, West, Wilson, Ye   +63 more
core   +1 more source

Sex- and limb-specific differences in the nitric oxide-dependent cutaneous vasodilation in response to local heating.

American Journal of Physiology. Regulatory Integrative and Comparative Physiology, 2014
Local heating of the skin is commonly used to assess cutaneous microvasculature function. Controversy exists as to whether there are limb or sex differences in the nitric oxide (NO)-dependent contribution to this vasodilation, as well as the NO synthase (
A. Stanhewicz, J. Greaney, W. Kenney, L. Alexander, Stanhewicz Ae, Greaney Jl, Kenney Wl, Alexander Lm Sex, L. Alexander   +8 more
semanticscholar   +1 more source