Results 71 to 80 of about 103,739 (262)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Integrating endothelium-derived hyperpolarization, nitric oxide, and prostacyclin pathways: the multimodal potential of human tissue kallikrein-1

Vascular Biology
Endothelial cells regulate vascular tone by releasing nitric oxide (NO) and prostacyclin (PGI2), as well as by initiating hyperpolarization of vascular smooth muscle cells through K+ channels and myoendothelial coupling.
Paolo Madeddu, Styliani Goulopoulou, David Wambeke   +2 more
doaj   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

Vasomotor responses are similar between outbred UM-HET3 and inbred C57BL/6J male and female mouse mesenteric resistance arteries

Frontiers in Physiology
ObjectiveGenetically diverse UM-HET3 (HET3) mice have emerged as a more robust model of human large artery dysfunction than the commonly used inbred C57BL/6J (C57) mice. However, HET3 resistance artery function has not been examined.
Robin C. Looft-Wilson, Surya Naraynan, Kathleen Salmon, Ethan Wunibald, Brian Simmons, Connor Haitz, Vishakha Shah, Margaret Xu   +7 more
doaj   +1 more source

Biomarkers of lung congestion and injury in acute heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 781-789, April 2025.
Abstract Acute heart failure (AHF) classification and management are primarily based on lung congestion and/or hypoperfusion. The quantification of the vascular and tissue lung damage is not standard practice though biomarkers of lung injury may play a relevant role in this context.
Marco Guazzi, Gabriele Novello, Francesca Bursi, Anna Caretti, Noemi Furlotti, Ross Arena, Paola Argiento, Julio Núñez, Antoni Bayes‐Genis, Marco Metra   +9 more
wiley   +1 more source

Dilatory effects and safety of a polyphenol-rich extract of Steganotaenia araliacea Hochst (Apiaceae) on rat aortic rings

Frontiers in Pharmacology
BackgroundHypertension is a major global public health concern. Many communities in developing countries still rely on medicinal plants as a source of primary healthcare for treatment of hypertension instead of conventional antihypertensive drugs ...
Newton Simfukwe, Lavina Prashar, James Nyirenda, Fastone Mathew Goma, Christian Chinyere Ezeala   +4 more
doaj   +1 more source

The Role of the NO/cGMP Pathway and SKCa and IKCa Channels in the Vasodilatory Effect of Apigenin 7-Glucoside

Molecules
This study aimed to elucidate the vasorelaxant mechanism of action for apigenin 7-glucoside (A7G) by integrating computational and ex vivo pharmacological approaches.
Maria Luiza Fidelis da Silva, Erdi Can Aytar, Arquimedes Gasparotto Junior   +2 more
doaj   +1 more source

Effects of flow‐controlled expiration on oxygenation and early recovery in horses undergoing general anaesthesia

Equine Veterinary Journal, EarlyView.
Abstract Background FLow‐controlled EXpiration (FLEX) has been shown to significantly enhance oxygenation in horses under clinical and experimental conditions. Objectives To compare pulmonary gas exchange during early recovery following general anaesthesia in horses ventilated with FLEX compared with conventional intermittent positive pressure ...
Allison Mika, Jerrianne Brandly, Alycia Frampton, Hope Douglas, Miranda Starr, Henry Benchimol, Klaus Hopster   +6 more
wiley   +1 more source

Levosimendan in Cardiogenic Shock: A Review of Mechanisms, Clinical Evidence, and Therapeutic Use

Reviews in Cardiovascular Medicine
Levosimendan is a calcium-sensitizing inodilator that has attracted renewed attention for a potential role in the management of cardiogenic shock (CS).
Stefano Salvini, Valeria Trivelloni, Ilenia Monaco, Fatima Samet Bouhaik, Insaf Chouarfia, Iheb Guefrachi, Yassine Bencharef, Mounia Sedrati, Charaf Mouhand, Dario Bottigliero   +9 more
doaj   +1 more source

Donkwa Enriched With Goron‐Tula (Azanza garckeana) Modulates Sexual Behavior and Activity of Enzymes Linked With Erectile Dysfunction in High‐Fat Diets/ Streptozotocin‐Induced (STZ/HFD) Diabetic Rats

Food Chemistry International, EarlyView.
(A) Mount number, (B) mount latency, (C) intromission number, and (D) intromission latency are the parameters of sexual behavior. Met = metformin. D100 = 100 Donkwa. D90G10 = 90% Donkwa + 10% Goron‐Tula. D85G15 = 85% Donkwa + 15% Goron‐Tula. D80G20 = 80% Donkwa + 20% Goron‐Tula. The mean ± standard error of the mean (SEM) expressed the results. *Values
O. T. Mamukuyomi, O. S. Ijarotimi, A. A. Badejo   +2 more
wiley   +1 more source