Results 91 to 100 of about 51,762 (264)

Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans [PDF]

, 2015
Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined.
Alexander, Alexander, Angelo, Badejo, Bailey, Baliga, Basu, Chen, Cosby, D'Souza, Dejam, DiFabio, Doyle, Furchgott, Ghosh, Gladwin, Golwala, Greenstein, Huellner, Huffman, Irvine, Johansson, Keith, Kollau, Koppaka, Larsen, Li, Lundberg, Mackenzie, Madhani, Maher, Maher, Marti, Ormerod, Paneni, Pawson, Perlman, Pinder, Tiso, Totzeck   +39 more
core   +2 more sources

Searching the ideal inhaled vasodilator: From nitric oxide to prostacyclin [PDF]

, 2002
Today, the technique to directly administer vasodilators via the airway to treat pulmonary hypertension and to improve pulmonary gas exchange is widely accepted among clinicians.
Habler, Oliver, Kemming, Gregor, Kisch-Wedel, Hille, Kleen, Martin, Welte, M., Zwissler, Bernhard   +5 more
core   +1 more source

Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials

Pediatric Anesthesia, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of prophylactic dexmedetomidine in preventing Junctional Ectopic Tachycardia (JET) and its impact on postoperative recovery in pediatric congenital heart surgery, restricting analysis to prospective trials. Methods We systematically searched PubMed, Scopus, and CENTRAL through October 16, 2025, for
Michelle Singh, Arjun Anilkumar, Rohit Vondivillu Srinivasan, Jasim Abdul Jabbar, Naghul Malaichamy, Rethin Jayaraman   +5 more
wiley   +1 more source

Case Report: Acral vasculitis induced by Immune Checkpoint Inhibitors: a case series and literature review

Frontiers in Oncology
IntroductionImmune Checkpoint Inhibitors (ICIs) may cause various immune- related Adverse Events (irAEs). Of these events, vascular involvement is still considered an uncommon irAEs and generally concerns large or medium vessels.
Valérian Rivet, Benoit Guillon, Vincent Sibaud, Jérémie Dion, Andréa Pastissier, Karen Delavigne, Pierre Cougoul, Odile Rauzy, Thibault Comont   +8 more
doaj   +1 more source

Development of an ex vivo model for the study of cerebrovascular function utilizing isolated mouse olfactory artery [PDF]

, 2015
OBJECTIVE: Cerebral vessels, such as intracerebral perforating arterioles isolated from rat brain, have been widely used as an ex vivo model to study the cerebrovascular function associated with cerebrovascular disorders and the therapeutic effects of ...
Dietrich, Hans H., Han, Byung Hee, Lee, Hyung-Jin, Zipfel, Gregory J.   +3 more
core   +2 more sources

Hormone Replacement Therapy for Menopausal Symptoms and the Risk of Cardiometabolic Disease: Current Evidence and Future Directions

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background The transition through menopause is accompanied by a series of adverse metabolic changes which are associated with an increased risk of cardiometabolic disease, a major cause of mortality in women after midlife. Whilst the indication for menopausal hormone replacement therapy (HRT) is the control of menopausal symptoms ...
Jiawen Dong, Sarah Hillman, Sharon Dixon, Anupa Shah, Radha Venkatakrishnan, Jeremy W. Tomlinson   +5 more
wiley   +1 more source

Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study

São Paulo Medical Journal
CONTEXT AND OBJECTIVES: Assessment of central blood pressure (BP) has grown substantially over recent years because evidence has shown that central BP is more relevant to cardiovascular outcomes than peripheral BP.
Renan Oliveira Vaz-de-Melo, Luiz Tadeu Giollo-Júnior, Débora Dada Martinelli, Heitor Moreno-Júnior, Marco Antônio Mota-Gomes, José Paulo Cipullo, Juan Carlos Yugar-Toledo, José Fernando Vilela-Martin   +7 more
doaj   +1 more source

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B [PDF]

, 2015
Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels
A Adebiyi, A Cheong, A Cogolludo, A Moreno-Dominguez, AJ Wilson, AM Brainard, B Kyle, B Razani, B Razani, C Dart, C Dart, Carl P. Nelson, CL Moore, CP Nelson, CP Nelson, DP McEwen, DW Carr, EA Aiello, EA Aiello, EA Ko, EA Ko, F Plane, GC Wellman, GI Purves, H Li, H Miyoshi, HS Mason, IA Greenwood, J Couet, J Moral-Sanz, JB Stott, JD Scott, JD Turner, Jennifer L. Brignell, JM Quayle, Jonathon M. Willets, JR Martens, KD Luykenaar, KS Park, LF Santana, LJ Sampson, LM Davies, M Colledge, Mark S. Shapiro, Matthew D. Perry, MF Navedo, MG Gold, MT Nelson, NM Alto, NN Orie, Noel W. Davies, O Clement-Chomienne, P Skroblin, R. A. John Challiss, RD Rainbow, RD Rainbow, RD Rainbow, RH Cox, RT Dobrowsky, SA Barman, VM Coghlan, Y Hayabuchi, Y Hayabuchi, Y Hayabuchi, Y Yang   +64 more
core   +2 more sources

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source