Results 111 to 120 of about 1,544,203 (251)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Subchronic Exposure to Arsenic and Nickel Triggers Nitrosative Stress and Histological Alterations in the Rat Liver

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3868-3881, November 2026.
ABSTRACT Environmental exposure to heavy metals poses a threat to human health. Several studies documented harmful effects on the liver after arsenic and nickel exposure at concentrations beyond permissible limits. Nevertheless, the impact of a simultaneous exposure to both elements on hepatic biochemistry and histology remains unelucidated. Therefore,
Thainá Iasbik‐Lima, Luiz Otávio Guimarães‐Ervilha, Isabela Pereira da Silva Bento, Renê Chagas da Silva, Mariana Machado‐Neves   +4 more
wiley   +1 more source

Effect of amlodipine on the circulating renin‐angiotensin‐aldosterone system in healthy cats

Journal of Veterinary Internal Medicine
Background Systemic hypertension (SH) is a common cardiovascular disease in older cats that is treated primarily with the calcium channel blocker amlodipine besylate (AML).
Tatiana M. Garcia Marrero, Jessica L. Ward, Melissa A. Tropf, Agnes Bourgois‐Mochel, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Debosmita Kundu, Jonathan P. Mochel   +8 more
doaj   +1 more source

Ability of the PulseCO Algorithm to Assess Changes in Stroke Volume Induced by Changes in Vascular Tone

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 10, November 2026.
ABSTRACT Background Vasoconstriction during anesthesia can influence stroke volume (SV) by preload modulation, making accurate SV monitoring essential to guide vasopressor therapy. Since gold standard methods like pulmonary artery catheterization and lithium dilution provide only intermittent estimates, continuous and less invasive arterial pulse ...
Jonathan Winther Olsen, Henrik Wolsted, Rune Sort, Mirjana Cihoric, Nicolai Bang Foss, Jakob Højlund   +5 more
wiley   +1 more source

Inhibitory effect of hypertonic mannitol on vasoconstrictor and vasodilator responses of isolated coronary arteries

, 1978
The effect of hypertonic mannitol on pressor responses to vasoactive agents was studied in isolated canine coronary arteries perfused with physiologic salt solution at a constant flow.
G. H. Templeton, V. S. Krishnamurty, H. R. Adams, J. T. Willerson   +3 more
core   +1 more source

Recent Pathophysiological Insights Are Advancing the Treatment of Venous Thromboembolism

JACC: Basic to Translational Science
Summary: Venous thromboembolism, defined as deep vein thrombosis and pulmonary embolism, is the third leading cause of cardiovascular deaths globally. Long-term complications of unresolved venous thrombi include post-thrombotic syndrome in the legs and ...
Satish Singh, PhD, Pardeep Kumar, MSc, Sudesh K. Yadav, PhD, Farouc A. Jaffer, MD, PhD, Guy L. Reed, MD   +4 more
doaj   +1 more source

Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?

Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley   +1 more source

Perspectives from Alzheimer's Disease Research Centers site directors on the early steps and the lasting impact

Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract Since the groundbreaking work of Alois Alzheimer in the early 1900s, Alzheimer's disease research has evolved immensely, most notably with the establishment of the Alzheimer's Disease Research Centers (ADRC). Fueled by the vision and funding of the National Institute on Aging (NIA), ADRCs have created a legacy through their work standardizing ...
John H. Growdon, John C. Morris, Ronald C. Petersen, Mary Sano, Lon S. Schneider   +4 more
wiley   +1 more source

Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues

Scientific Reports
People of all age categories and lifestyles suffer to different extents from hypertension. Accordingly, this necessitates the rise of new ways to defeat this enemy.
Marian W. Aziz, Khaled O. Mohamed, Doaa B. Farag, Amira Karam Khalifa, Zeinab Mahmoud   +4 more
doaj   +1 more source

Cancer and Hypertension: Shared Mechanisms, Treatment Interactions, and Clinical Management

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Cancer and hypertension (HTN) frequently coexist, and their relationship is increasingly recognized as a clinically relevant intersection between oncology and cardiovascular medicine. However, the extent to which this association reflects shared risk factors, common biological mechanisms, or treatment‐related effects remains incompletely ...
Peizhi Jia, Daxin Chen, Jingting Wang, Yupei Guo, Jinhong Liu, Jiumao Lin   +5 more
wiley   +1 more source