Results 121 to 130 of about 51,762 (264)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Cardiovascular β‐Adrenergic Receptor Distribution and Function: Influence of Species, Sex, Age, and Tissue

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Estrogen modulates β‐AR signaling in a context‐dependent manner influenced by species, sex, age, tissue, and vascular health, highlighting challenges in translating findings from experimental models to human cardiovascular physiology. ABSTRACT Cardiovascular diseases remain the leading global cause of morbidity and mortality, with notable sex‐specific ...
Basant Elsaid, Irakli Kopaliani, Birgit Zatschler, Ansam Seif, Stephan Speier, Andreas Deussen   +5 more
wiley   +1 more source

Implementation of OMOP and ConcePTION Common Data Models in CPRD GOLD: Risk of Bleeding and Cardiovascular Outcomes From Anticoagulant Use

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1574-1583, June 2026.
The impact of the choice of common data model (CDM) approach on the study results in a real‐world evidence (RWE) study is unknown. We aimed to determine potential differences in the results of an RWE study when data were mapped to two different CDMs, ConcePTION and OMOP. With the same instance of CPRD GOLD, data were mapped to both CDMs. Using the same
Nicholas B. Hunt, Patrick Souverein, Marloes Bazelier, Nicola Barclay, Antonella Delmestri, Miriam Sturkenboom, Daniel Prieto‐Alhambra, Helga Gardarsdottir, Olaf Klungel   +8 more
wiley   +1 more source

Effect of amlodipine on the circulating renin‐angiotensin‐aldosterone system in healthy cats

Journal of Veterinary Internal Medicine
Background Systemic hypertension (SH) is a common cardiovascular disease in older cats that is treated primarily with the calcium channel blocker amlodipine besylate (AML).
Tatiana M. Garcia Marrero, Jessica L. Ward, Melissa A. Tropf, Agnes Bourgois‐Mochel, Emilie Guillot, Oliver Domenig, Lingnan Yuan, Debosmita Kundu, Jonathan P. Mochel   +8 more
doaj   +1 more source

Recent Pathophysiological Insights Are Advancing the Treatment of Venous Thromboembolism

JACC: Basic to Translational Science
Summary: Venous thromboembolism, defined as deep vein thrombosis and pulmonary embolism, is the third leading cause of cardiovascular deaths globally. Long-term complications of unresolved venous thrombi include post-thrombotic syndrome in the legs and ...
Satish Singh, PhD, Pardeep Kumar, MSc, Sudesh K. Yadav, PhD, Farouc A. Jaffer, MD, PhD, Guy L. Reed, MD   +4 more
doaj   +1 more source

Hyperkinetic Movement Disorder as the First Manifestation of Moyamoya Disease in a 15‐Year‐Old: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Physicians evaluating pediatric movement disorders, especially chorea, should consider a broad differential diagnosis, including vascular etiologies such as moyamoya disease. Prompt recognition, appropriate neuroimaging, and early diagnosis are crucial for guiding management and optimizing patient outcomes.
Lina Okar, Reema Gowda, Hadeel Alzoubi, Karthik Narayanan, Maxwell Wallace   +4 more
wiley   +1 more source

Quantitative Assessment of Myocardial Perfusion in Physiological and Pathological Hypertrophy Using Myocardial Contrast Echocardiography

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Myocardial hypertrophy can be classified into physiological and pathological types based on etiology, with significant differences in clinical outcomes. This study utilized myocardial contrast echocardiography to quantitatively assess myocardial microcirculatory perfusion in patients with different types of hypertrophy.
Liu Chunyao, Jiang Ruihan, Li Kai, Lin Mingming, Wang Xiaofan, Lv Qifeng, Song Xiaoxia, Tian Yu, Sun Juanjuan, Sun Pin   +9 more
wiley   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Synthesis of potent vasodilating agents: in silico and in vitro evaluation of 6-(4-substitutedphenyl)-3-pyridazinone derivatives as potential hydralazine analogues

Scientific Reports
People of all age categories and lifestyles suffer to different extents from hypertension. Accordingly, this necessitates the rise of new ways to defeat this enemy.
Marian W. Aziz, Khaled O. Mohamed, Doaa B. Farag, Amira Karam Khalifa, Zeinab Mahmoud   +4 more
doaj   +1 more source

The Role of Nootropic Supplements in Sports: Enhancing Cognitive and Physical Performance Simultaneously

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
The review examines the nootropic effects of substances used in sports through their impact on neurotransmission, neuroendocrine control, energy production, synaptic plasticity, and neurovascular connections. The four key neurotransmitters dopamine, acetylcholine, serotonin, and GABA function to control motivation, attention, fatigue perception, and ...
Zheng Yi
wiley   +1 more source