Results 41 to 50 of about 53,380 (285)

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source

An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat [PDF]

, 2015
In the absence of an ability to absorb fluid by cellular uptake mechanisms, fluid movement in vivo from the perfused rat intestine is absorptive when the diastolic blood pressure is normal or very low but is secretory when blood pressure falls below ...
Lucas, Michael, Morrison, James
core   +1 more source

Differential sensitivity of basal and acetylcholine-induced activity of nitric oxide to blockade by asymmetric dimethylarginine (ADMA) in the rat aorta [PDF]

, 2010
<b>Background and purpose</b>: Previous work has shown that NG-monomethyl-l-arginine (l-NMMA) paradoxically inhibits basal, but not ACh-stimulated activity of nitric oxide in rat aorta.
Archer, Boger, Cocks, De Gennaro Colonna, Dora, Dudzinski, Feng, Fleming, Frew, Fulton, Gallis, Hobbs, Jackson, Jin, Leiper, Liu, Martin, Martin, Miller, Moore, Olken, Overend, Palmer, Rapoport, Rees, Rees, Siroen, Vallance, Vallance, Vladimirova-Kitova   +29 more
core   +3 more sources

Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]

, 2020
Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar, Banno, Bekendam, Bi, Chagas, Chagas, Chang, Chen, Chung, Dang, De Bona, Dutta-Roy, Essex, Essex, Essex, Ghoshal, Giamogante, Giamogante, Holbrook, Inoue, Jarvis, Jasuja, Jayakumar, Jordan, Kang, Kehrel, Kim, Lahav, Lakowicz, Lescano, Lin, Lu, Mangin, Masuda, Navarro-Nuñez, Park, Raffaelli, Raturi, Sharma, Sousa, Stopa, Taylor, Trnkova, Wang, Ware, Wendelboe   +45 more
core   +1 more source

Long-Term Prognostic and Hemodynamic Outcomes of Intensive Immunosuppressive Therapy in Patients With Pulmonary Arterial Hypertension Associated With Connective Tissue Disease. [PDF]

Int J Rheum Dis
ABSTRACT Background Intensive immunosuppressive therapy (IIT) is recommended for PAH associated with connective tissue disease (CTD‐PAH). However, the long‐term effects of IIT on pulmonary hemodynamics in this population remain unexplored. Additionally, its effectiveness in patients with systemic sclerosis (SSc)‐associated PAH (SSc‐PAH) is poorly ...
Yamada K, Yaoita N, Satoh T, Yamamoto S, Yamada Y, Chiba N, Komaru K, Sato H, Kikuchi N, Suzuki H, Nochioka K, Tatebe S, Miyata S, Ishii T, Yasuda S.   +14 more
europepmc   +2 more sources

A guide to reactive oxygen species in tumour hypoxia: measurement and therapeutic implications

Molecular Oncology, EarlyView.
Hypoxia reshapes tumour redox landscapes by altering compartmental ROS production (mitochondria, NOX, ER, peroxisomes). Accurate interpretation requires oxygen‐contextualised measurement (live biosensors, chemical probes, EPR, LC–MS) and awareness of artefacts (reoxygenation, probe specificity).
Lina Hacker, Elysia Sarsam, Stuart J. Conway, Ester M. Hammond   +3 more
wiley   +1 more source

Recombinant interleukin-1β dilates steelhead trout coronary microvessels : effect of temperature and role of the endothelium, nitric oxide and prostaglandins [PDF]

, 2015
© 2015. Published by The Company of Biologists Ltd. Acknowledgements We thank Wenjuan Xu and Xin Xu (Hein Lab) for their excellent instruction in microvessel techniques, Dr David Heeley (Biochemistry Department, MUN) for assistance with selecting an ...
Amelio, Amelio, Andreakis, Bataillard, Beasley, Berne, Buonocore, Chilian, Chiu, Combes, Costa, Dinarello, Duling, Duncan, Fago, Farrell, Farrell, Farrell, Farrell, Fritsche, Gamperl, Gamperl, Gamperl, Gollock, González-Domenech, Graff, Gräns, Hein, Helwig, Hirafuji, Holland, Hong, Hong, Imbrogno, Ishizaka, Jedrzejowska-Szypulka, Jennings, Kanno, Kiceniuk, Kuo, Kuo, Kågström, Leon, Lepiller, Lin, Lüscher, Maher, Marceau, McKean, McNeill, Miller, Mollace, Mustafa, Mustafa, Nilsson, Oliveira, Olson, Olson, Olson, Olson, Osuka, Park, Peddie, Peddie, Perry, Proescholdt, Pérez-Casanova, Radin, Rossi, Salvemini, Schiltz, Shi, Shibata, Shimokawa, Taniguchi, Tsujino, Vassalle, Wang, Warner, Warner, Zou, Zou   +81 more
core   +3 more sources

Perfusable Brain Microvascular Network‐On‐Chip Model to Study Flavivirus NS1‐Induced Endothelial Dysfunction

Advanced Functional Materials, EarlyView.
This study presents a microfluidic brain microvascular network‐on‐chip (BMVasChip) to investigate endothelial barrier dysfunction caused by flavivirus non‐structural protein 1 (NS1), including virus‐ and time‐dependent vascular damage, leakiness, and dysfunction.
Monika Rajput, Yen‐Ting Tung, Yu‐Chi Chen, Min Jae Song, Marc Ferrer, Emily M. Lee   +5 more
wiley   +1 more source

Characterizing cardiac involvement in chronic kidney disease using CMR—a systematic review [PDF]

, 2018
Purpose of Review: The aim of the review was to identify and describe recent advances (over the last 3 years) in cardiac magnetic resonance (CMR) imaging in patients with chronic kidney disease (CKD).
Mangion, Kenneth, Mark, Patrick B., McDowell, Kirsty, Rutherford, Elaine   +3 more
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source