Results 21 to 30 of about 51,762 (264)

Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair [PDF]

, 2015
A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of ...
Olson, Eric N., van Rooij, Eva
core   +1 more source

Anti-migraine agents from an immunological point of view

Journal of Translational Medicine, 2021
The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs.
Bakri M. Assas
doaj   +1 more source

Present and future pharmacotherapeutic agents in heart failure: an evolving paradigm [PDF]

, 2016
Many conditions culminate in heart failure (HF), a multi-organ systemic syndrome with an intrinsically poor prognosis. Pharmacotherapeutic agents that correct neurohormonal dysregulation and haemodynamic instability have occupied the forefront of ...
Abozguia, AIRE Study Group, Alexander, Alexander, Alexander, Alexander, Ashrafian, Bailey, Bailey, Basu, Beadle, Braunwald, Brown, Burgoyne, Chaitman, Chatterjee, Chung, CIBIS-II Study Group, Cleland, Clerc, Cohn, Cohn, Cohn, CONSENSUS Trial Study Group, Conway, Cook, Dai, Digitalis Investigation Group, Doenst, Dzau, Dzau, Faris, Flather, Follath, Foster, Fox, Fox, Fragasso, Furberg, Gheorghiade, Gladwin, Goffart, Granger, Greenberg, Guazzi, Guazzi, Heymans, Hobbs, Holubarsch, Horowitz, Horowitz, Kantor, Kapil, Kato, Kennedy, Kennedy, Kostis, Larsen, Lee, Lopaschuk, Luiken, Lundberg, Maher, Maier, Mancini, Mann, Mann, Massie, Mccormack, Mcdowell, Mcmurray, Mcmurray, Merit-Hf Study Group, Munzel, Munzel, Neglia, Neubauer, Ormerod, Packer, Packer, Paul, Pawson, Pfeffer, Pfeffer, Pitt, Pitt, Rathore, Rauchhaus, Redfield, Rona, Sack, Sarraf, Schmidt-Schweda, Schrauwen, Schwarz, Shah, Shah, Siddiqi, Singh, SOLVD Investigators, Stanley, Swedberg, Szwed, Taylor, Teerlink, Tilemann, Torre-Amione, Totzeck, Turcani, Unger, Van Der Vusse, Van Faassen, Vardeny, Webb, Yin, Yusuf, Zamani, Zannad, Zannad, Zhang   +119 more
core   +1 more source

The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation [PDF]

, 2004
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the ...
Furman W.R., Karzai W., Karzai W., Marin J.L., Russell W.J.   +4 more
core   +2 more sources

Direct Vasodilators and Sympatholytic Agents

Journal of Cardiovascular Pharmacology and Therapeutics, 2015
Direct vasodilators and sympatholytic agents were some of the first antihypertensive medications discovered and utilized in the past century. However, side effect profiles and the advent of newer antihypertensive drug classes have reduced the use of these agents in recent decades.
Meghan N, McComb, James Y, Chao, Tien M H, Ng   +2 more
openaire   +2 more sources

Requirement for sphingosine kinase 1 in mediating phase 1 of the hypotensive response to anandamide in the anaesthetised mouse [PDF]

, 2019
In the isolated rat carotid artery, the endocannabinoid anandamide induces endothelium-dependent relaxation via activation of the enzyme sphingosine kinase (SK).
Alganga, Husam, Ballantyne, Margaret D., Ewart, Marie-Ann, Fertig, Bracy, Greig, Fiona H., Kazi, Zeshan H., Kennedy, Simon, Nather, Katrin, Pyne, Nigel J., Pyne, Susan, Zaborska, Karolina E.   +10 more
core   +2 more sources

Sudden sensorineural hearing loss – A contemporary review of management issues

Journal of Otology, 2020
Sudden sensorineural hearing loss (SSNHL) is an enigmatic entity, with obscure pathophysiology and debatable efficacy of the treatment agents used. An underlying cause is identified in only 10–15% of cases.
Anup Singh, David Victor Kumar Irugu
doaj   +1 more source

Pulmonary Hypertension Registry of Kerala, India (PRO-KERALA): One-year outcomes

Indian Heart Journal, 2022
Background: Short term outcomes of patients with pulmonary hypertension are not available from low and middle-income countries including India. Methods: We conducted a prospective study of 2003 patients with pulmonary hypertension, from 50 centres ...
S. Harikrishnan, Avinash Mani, Sanjay G, Ashishkumar M, Jaideep Menon, Rajesh G, R. Krishna Kumar, A. George Koshy, Thankachan V. Attacheril, Raju George, Eapen Punnose, S.M. Ashraf, Arun SR, Mohammed Cholakkal, Panniyammakal Jeemon, Stigi Joseph, Unni Govindan, Johny Joseph, Koshy Eapen, Madhu Sreedharan, Anil Kumar, K. Venugopal   +21 more
doaj   +1 more source

Alpha1 -adrenergic stimulation selectively enhances endothelium-mediated vasodilation in rat cremaster arteries. [PDF]

, 2018
We have systematically investigated how vascular smooth muscle α1 -adrenoceptor activation impacts endothelium-mediated vasodilation in isolated, myogenically active, rat cremaster muscle 1A arteries.
Braun, Andrew P, Davis, Michael J, Hill, Michael A, Mishra, Ramesh C, Rahman, Mohammad M, Wulff, Heike   +5 more
core   +1 more source

The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats

Archives of Plastic Surgery, 2015
Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied.
Utku Can Dölen, Nezih Sungur, Gökhan Koca, Onur Ertunç, Ayşe Tülay Bağcı Bosi, Uğur Koçer, Meliha Korkmaz   +6 more
doaj   +1 more source