Results 21 to 30 of about 30,809 (165)

The Role of the ACE2/MasR Axis in Ischemic Stroke: New Insights for Therapy

Biomedicines, 2021
Ischemic stroke remains the leading cause of neurologically based morbidity and mortality. Current stroke treatment is limited to two classes of FDA-approved drugs: thrombolytic agents (tissue plasminogen activator (tPA)) and antithrombotic agents ...
Mansoureh Barzegar, Karen Y. Stokes, Oleg Chernyshev, Roger E. Kelley, Jonathan S. Alexander   +4 more
doaj   +1 more source

Aminophylline shortage and current recommendations for reversal of vasodilator stress: an ASNC information statement endorsed by SCMR

Journal of Cardiovascular Magnetic Resonance, 2018
Pharmacologic reversal of serious or intolerable side effects (SISE) from vasodilator stress is an important safety and comfort measure for patients experiencing such effects. While typically performed using intravenous aminophylline, recurrent shortages
Aiden Abidov, Vasken Dilsizian, Rami Doukky, W. Lane Duvall, Christopher Dyke, Michael D. Elliott, Fadi G. Hage, Milena J. Henzlova, Nils P. Johnson, Ronald G. Schwartz, Gregory S. Thomas, Andrew J. Einstein   +11 more
doaj   +1 more source

Impact of a TAK-1 inhibitor as a single or as an add-on therapy to riociguat on the metabolic reprograming and pulmonary hypertension in the SUGEN5416/hypoxia rat model

Frontiers in Pharmacology, 2023
Background: Despite increasing evidence suggesting that pulmonary arterial hypertension (PAH) is a complex disease involving vasoconstriction, thrombosis, inflammation, metabolic dysregulation and vascular proliferation, all the drugs approved for PAH ...
Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Daniel Morales-Cano, Jose Luis Izquierdo-García, Jose Luis Izquierdo-García, Jose Luis Izquierdo-García, Bianca Barreira, Bianca Barreira, Bianca Barreira, Sergio Esquivel-Ruiz, Sergio Esquivel-Ruiz, Sergio Esquivel-Ruiz, Maria Callejo, Maria Callejo, Maria Callejo, Rachele Pandolfi, Rachele Pandolfi, Rachele Pandolfi, Palmira Villa-Valverde, Palmira Villa-Valverde, Ignacio Rodríguez, Ignacio Rodríguez, Angel Cogolludo, Angel Cogolludo, Angel Cogolludo, Jesus Ruiz-Cabello, Jesus Ruiz-Cabello, Jesus Ruiz-Cabello, Francisco Perez-Vizcaino, Francisco Perez-Vizcaino, Francisco Perez-Vizcaino, Laura Moreno, Laura Moreno, Laura Moreno   +35 more
doaj   +1 more source

Direct Vasodilators and Sympatholytic Agents

Journal of Cardiovascular Pharmacology and Therapeutics, 2015
Direct vasodilators and sympatholytic agents were some of the first antihypertensive medications discovered and utilized in the past century. However, side effect profiles and the advent of newer antihypertensive drug classes have reduced the use of these agents in recent decades.
Meghan N, McComb, James Y, Chao, Tien M H, Ng   +2 more
openaire   +2 more sources

Anti-migraine agents from an immunological point of view

Journal of Translational Medicine, 2021
The new wave of anti-migraine agents is nothing less than a milestone in our battle to manage this devastating disease. However, concerns have recently increased regarding the safety of these drugs.
Bakri M. Assas
doaj   +1 more source

Sudden sensorineural hearing loss – A contemporary review of management issues

Journal of Otology, 2020
Sudden sensorineural hearing loss (SSNHL) is an enigmatic entity, with obscure pathophysiology and debatable efficacy of the treatment agents used. An underlying cause is identified in only 10–15% of cases.
Anup Singh, David Victor Kumar Irugu
doaj   +1 more source

Pulmonary Hypertension Registry of Kerala, India (PRO-KERALA): One-year outcomes

Indian Heart Journal, 2022
Background: Short term outcomes of patients with pulmonary hypertension are not available from low and middle-income countries including India. Methods: We conducted a prospective study of 2003 patients with pulmonary hypertension, from 50 centres ...
S. Harikrishnan, Avinash Mani, Sanjay G, Ashishkumar M, Jaideep Menon, Rajesh G, R. Krishna Kumar, A. George Koshy, Thankachan V. Attacheril, Raju George, Eapen Punnose, S.M. Ashraf, Arun SR, Mohammed Cholakkal, Panniyammakal Jeemon, Stigi Joseph, Unni Govindan, Johny Joseph, Koshy Eapen, Madhu Sreedharan, Anil Kumar, K. Venugopal   +21 more
doaj   +1 more source

The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats

Archives of Plastic Surgery, 2015
Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied.
Utku Can Dölen, Nezih Sungur, Gökhan Koca, Onur Ertunç, Ayşe Tülay Bağcı Bosi, Uğur Koçer, Meliha Korkmaz   +6 more
doaj   +1 more source

How do antihypertensive drugs work? Insights from studies of the renal regulation of arterial blood pressure.

Frontiers in Physiology, 2016
Though antihypertensive drugs have been in use for many decades, the mechanisms by which they act chronically to reduce blood pressure remain unclear.
Holly Digne-Malcolm, Matthew Charles Frise, Keith Leonard Dorrington   +2 more
doaj   +1 more source

RANDOMIZED EXPERIMENTAL STUDY OF TOPICAL VASODILATORS IN MICROSURGERY WITH COST ANALYSIS [PDF]

Acta Ortopédica Brasileira
Objective: Throughout microsurgical anastomosis, many surgeons use topical vasodilators in order to reduce pathological vasospasm. It was carried out an experimental study comparing the effectiveness of topical use of Nitroglycerin, Papaverine, Magnesium
Renato Polese Rusig, Debora Yumi Yoshimura Orlandin Alves, Amanda de Oliveira Silva Nascimento, Gustavo Bispo dos Santos, Rames Mattar Jr, Raquel Bernardelli Iamaguchi   +5 more
doaj   +1 more source