Results 171 to 180 of about 182,855 (396)

Compartmentalisation in cAMP signalling: A phase separation perspective

open access: yesBritish Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Static and Dynamic Balance Is Impaired in Patients With Long‐Term, Well‐Controlled Acromegaly: A Cross‐Sectional Study

open access: yesClinical Endocrinology, EarlyView.
ABSTRACT Objective Balance impairment is an underrecognized complication of acromegaly with potentially serious consequences for affected patients. In this study, we aimed to assess the balance in patients with long‐term acromegaly compared to non‐acromegalic controls. Design Cross‐sectional study.
Christian Rosendal   +4 more
wiley   +1 more source

Effectiveness of Octocog Alfa (BAY 81‐8973) to Treat People With Haemophilia A Enrolled in the ATHNdataset, Including Under‐Represented Subgroups

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Objectives To evaluate the real‐world effectiveness of octocog alfa (BAY 81‐8973; Kovaltry) in people with haemophilia A (PwHA), including under‐represented subgroups. Methods We retrospectively analysed the American Thrombosis and Hemostasis Network (ATHN) dataset to identify the characteristics, treatment/clinical histories and annualised ...
Martin Chandler   +4 more
wiley   +1 more source

Volume kinetics of lactated Ringer's solution in adult horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Fluid therapy in horses is primarily empirical. Evidence‐based quantification of the disposition of intravenous (IV) crystalloids used in clinical practice could enhance the effectiveness of fluid therapy. Objectives To determine the pharmacokinetics (i.e., volume kinetics: VK) and associated haemodynamic effects of IV lactated ...
William W. Muir   +3 more
wiley   +1 more source

Exploring the roles of conserved context‐dependent cis‐regulatory elements (cdCREs) in multicellularity, human health and disease

open access: yesThe FEBS Journal, EarlyView.
Conserved context‐dependent cis‐regulatory elements act as a major reservoir of disease‐associated polymorphisms in the human genome and are also affected by epigenetic change. This ‘state‐of‐the‐art’ review explores the latest developments in studying these enigmatic elements and how the effects of disease‐associated polymorphisms and environmentally ...
Andrew McEwan   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy