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Vasopressin and vasopressin receptors in brain edema

2020
Vasopressin is a peptide hormone produced in the hypothalamus and released from the posterior pituitary. Secretion of vasopressin is followed by activation of its receptors V1a, V1b, and V2 throughout the body. Each receptor type is responsible for a specific function of vasopressin.
J Paul Elliott   +2 more
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Biosynthesis of Vasopressin

Journal of Cardiovascular Pharmacology, 1986
The nonapeptide vasopressin is synthetized as part of a longer common precursor polypeptide, together with its carrier protein neurophysin and a glycopeptide of unknown function. The gene for this common precursor has been isolated and sequenced and shown to comprise three exons encoding, respectively, the protein domains approximately corresponding to
Dietmar Richter   +2 more
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Vasopressin and Vasopressin Antagonists in Heart Failure

2017
Despite the introduction of multiple new pharmacological agents over the past three decades in the field of heart failure (HF), overall prognosis remains poor. Hyponatremia is prevalent in HF patients and has been suggested as a contributor to poor response to standard therapy.
Finn Gustafsson   +1 more
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Vasopressin antagonists

Cellular and Molecular Life Sciences, 2006
Effects of vasopressin via V1a- and V2-receptors are closely implicated in a variety of water-retaining diseases and cardiovascular diseases, including heart failure, hyponatraemia, hypertension, renal diseases, syndrome of inappropriate antidiuretic hormone secretion, cirrhosis and ocular hypertension.
Lemmens, Rosa, Kamyar, Majid-Reza
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Vasopressin in the ICU

Current Opinion in Critical Care, 2004
Vasopressin is one of the most important endogenously released stress hormones during shock. In this review, studies published in the past year that add to our understanding of the use of vasopressin in the ICU are discussed.Endogenous vasopressin levels are inappropriately low in adults with severe sepsis but not in children with meningococcal septic ...
Keith R. Walley, Cheryl L. Holmes
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Vasopressin Receptors

Trends in Endocrinology & Metabolism, 2000
The biological effects of arginine vasopressin (AVP) are mediated by three receptor subtypes: the V1a and V1b receptors that activate phospholipases via Gq/11, and the V2 receptor that activates adenylyl cyclase by interacting with Gs. Isolation of the cDNAs encoding the V1a and V1b receptor subtypes explained the tissue variability of V1 antagonist ...
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Vasopressin and vasopressin antagonists in heart failure and hyponatremia

Current Heart Failure Reports, 2008
Increased synthesis of arginine vasopressin (AVP) plays a critical role in fluid retention and hyponatremia in patients with heart failure. The AVP receptor antagonists constitute a new class of agents that are promising in the management of hyponatremia and congestion.
Mihai Gheorghiade   +3 more
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Vasopressin

2016
Vasopressins (VPs) are mammalian VP family nonapeptides. VPs are composed of an intramolecular ring structure flanked by two cysteine residues and a C-terminal extension with a basic amino acid residue at position 8. VP causes antidiuresis, blood pressure elevation, stress response, metabolic actions, and various behaviors through three VP receptors. A
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Vasopressin studies in the rat

Pfl�gers Archiv f�r die Gesamte Physiologie des Menschen und der Tiere, 1968
A modification of Jeffers method for estimating antidiuretic hormone in body fluids is described. With this modification it is possible to detect antidiuretic activity corresponding to 0.25 μU of Vasopressin.
O. H. Gauer, P. S. Tata
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Renal microvascular effects of vasopressin and vasopressin antagonists

American Journal of Physiology-Renal Physiology, 1989
The effects of vasopressin (AVP) and vasopressin antagonists on lumen diameters of cortical afferent and efferent arterioles isolated from rabbit kidneys were examined. Over a concentration range of 10(-14) to 10(-7) M, AVP had no effect on lumen diameters of afferent arterioles, although the arterioles were responsive to norepinephrine.
R. M. Edwards, W. Trizna, L. B. Kinter
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