Results 61 to 70 of about 61,568 (194)

A Polyproline type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein‐protein Interaction Implicated in Breast Cancer

ChemBioChem, Accepted Article.
Given the essential role of protein‐protein interactions (PPIs) in cellular signalling pathways their selective modulation is of great therapeutic interest. Mimicry of secondary structural protein elements has emerged as a promising strategy, with various scaffolds reproducing recognition surfaces of α‐helical and β‐strand/sheet proteins.
James Luccarelli, Philip C. Simister, Andrew D. Hamilton, Stephan M. Feller, Sam Thompson   +4 more
wiley   +1 more source

A visual motor psychological test as a predictor to treatment in nocturnal enuresis [PDF]

, 2002
Background and Aims: The neurological control of bladder function and the ability to be dry at night involves not only the acquisition of normal daytime control, but also the establishment of a circadian rhythm in vasopressin release and the ability to ...
Barrow, S, Bosson, S, Holland, PC
core   +2 more sources

A Rare Case of Nitroglycerin Resistant Coronary Arterial Vasospasm During Coronary Artery Bypass Surgery

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary artery vasospasm following coronary artery bypass grafting (CABG) is a rare but potentially life‐threatening complication that can lead to myocardial ischemia, arrhythmias, and cardiogenic shock. Nitroglycerin‐resistant vasospasm, particularly involving the left main coronary artery (LMCA), poses significant diagnostic and ...
Dina Soliman, Cristian Castillo‐Rodriguez, Diego Cruz, John Abdelmalek   +3 more
wiley   +1 more source

An Efficient Thiol‐ene Mediated Protocol for Thiolated Peptide Synthesis and On‐Resin Diversification

Chemistry – A European Journal, EarlyView.
Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa, Conor Williams, Konstantin Raabe, Joshua T. McLean, Markus Muttenthaler, Eoin M. Scanlan   +5 more
wiley   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Nausea: Current knowledge of mechanisms, measurement and clinical impact [PDF]

, 2015
Nausea is a subjective sensation, which often acts as a signal that emesis is imminent. It is a widespread problem that occurs as a clinical sign of disease or as an adverse effect of a drug therapy or surgical procedure.
Aapro, Alphin, Andrews, Andrews, Andrews, André, Beleslin, Chelen, Chen, Cluny, Coil, Conder, Cross-Mellor, Cubeddu, Cubeddu, Cubeddu, Cubeddu, Cullen, Davidson, de la Puente-Redondo, Diemunsch, Doweck, Elwood, Fan, Foss, Fredrikson, Fredrikson, Gralla, Hahn, Hannah Kenward, Hay Kraus, Hickman, Hikasa, Holmes, Horn, Horn, Hornby, Hu, Japundzic-Zigon, Jenns, Jonathan Elliott, Karine Savary-Bataille, Kenward, Kim, Koch, Koch, Koivuranta, Kowalski, Krawiec, Kretzing, Kretzing, Kristal, Kvale, Lacasse, Le Bars, Leeser, Limebeer, Limebeer, Limebeer, Limebeer, Limebeer, Limebeer, Lucot, Ludovic Pelligand, Mantione, Mayer, Medleau, Melzack, Miller, Minami, Minami, Morrow, Morrow, Morrow, Muth, Napadow, Otto, Parker, Parker, Parker, Parker, Poli-Bigelli, Quimby, Rau, Ritter, Rock, Roila, Rossmeisl, Rowe, Sanger, Sanger, Schwartz, Sedlacek, Shelke, Soderpalm, Stern, Tatewaki, Tramer, Vaha-Vahe, Villablanca, Watson, Yamakuni, Yamamoto, Yap, Yu   +104 more
core   +1 more source

Recycling spent synthesis liquor for enhanced production of ZIF‐67: Characterization and morphological insights

ChemNanoMat, Accepted Article.
This study reports the preparation and characterization of ZIF‐67 through the recycling of spent synthesis liquor containing unreacted 2‐methylimidazole. Materials were characterized using XRD, SEM, N2 physisorption, and SAXS. The recycling enhanced the yield of ZIF‐67 while maintaining the dodecahedral rhombic morphology of the particles. In the first
Lucas Leocadio Battiston, Barbara Gerbelli, Fabiano Yokaichiya, Ivan Ricardo Barros, Kátia Dionísio Oliveira, Cícero Naves Ávila-Neto   +5 more
wiley   +1 more source

Epitaxy and Topotaxy in the Aragonite‐Calcite Polymorphism

Crystal Research and Technology, EarlyView.
At first distinguish epitaxy from topotaxy, which rule the main mechanisms of calcite‐aragonite transitions. Then, attempt to move from qualitative to quantitative descriptions of these transitions. Hence, it will deal with 2D (epitaxy) and 3D (topotaxy) conversions in the polymorphic system, in order to gain insight on their differences.
D. Aquilano, S. Frisia, S. Ghignone, M. Bruno   +3 more
wiley   +1 more source

Towards the convergent therapeutic potential of G protein‐coupled receptors in autism spectrum disorders

British Journal of Pharmacology, EarlyView., 2023
Abstract Autism spectrum disorders (ASDs) are diagnosed in 1/100 children worldwide, based on two core symptoms: deficits in social interaction and communication, and stereotyped behaviours. G protein‐coupled receptors (GPCRs) are the largest family of cell‐surface receptors that transduce extracellular signals to convergent intracellular signalling ...
Anil Annamneedi, Caroline Gora, Ana Dudas, Xavier Leray, Véronique Bozon, Pascale Crépieux, Lucie P. Pellissier   +6 more
wiley   +1 more source

A Simple Strategy for Co‐Immobilization of NADH‐Dependent Enzymes and NADH for Efficient Biocatalysis in Continuous Flow Reactors

ChemSusChem, EarlyView.
Polyethylenimine‐modified Cry3Aa‐formate dehydrogenase (FDH)/Cry3Aa‐leucine dehydrogenase (LDH) fusion particles entrapped in agarose beads enables efficient NADH recycling, thereby facilitating the continuous synthesis of chiral intermediates in a flow reactor.
Reza Yekta, Xu Xiong, Marianne M. Lee, Michael K. Chan   +3 more
wiley   +1 more source