Results 81 to 90 of about 53,940 (250)

Urinary alcohol and ethyl glucuronide as a screening tool for alcohol use in pregnancy: A multicenter prospective study

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
In this objective, anonymous study of 1053 women attending their first antenatal appointment, a surprisingly low percentage (0.38%) contained ethyl glucuronide (EtG), a metabolite of alcohol. These findings challenge previous studies that suggest that up to 60% of pregnant women in Ireland consume alcohol during pregnancy. Abstract Introduction Reports
Ciara A. McCormick, Grace Mealy, Caroline Donaghy, Patricia Gordon, Elizabeth Dunn, Pauline Carroll, Alfonso Rodriguez‐Herrera, Conrado M. Cusnaider, William Ebbitt, Peter A. McCormick, Fionnuala M. McAuliffe   +10 more
wiley   +1 more source

Tau‐targeting active immunotherapy slows progression and reduces pathology in mouse models of tauopathy

Brain Pathology, EarlyView.
The efficacy of the novel anti‐tau active immunotherapy, p5555kb, was tested using two mouse models of tau pathology. p5555kb inoculation increased the survival rate and reduced tau pathology in tau‐overexpressing P301L mice and decreased tau seeding in the brains of C57BL/6 mice injected with human‐purified Alzheimer's disease tau.
Christopher M. Brown, Jeanne K. Brooks, Louise Kelly, Madeline M. Vroom, Matthew Longo, Jean‐Cosme Dodart, Roxana Carare, Justin D. Boyd   +7 more
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

The Voice of a Disease: Why Food Noise Can No Longer Be Ignored!

Obesity, EarlyView.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies

Clinical Endocrinology, EarlyView.
ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley   +1 more source

The Association Between Vasopressin and Adverse Kidney Outcomes in Children and Young Adults Requiring Vasopressors on Continuous Renal Replacement Therapy

Critical Care Explorations
OBJECTIVES:. Continuous renal replacement therapy (CRRT) and shock are both associated with high morbidity and mortality in the ICU. Adult data suggest renoprotective effects of vasopressin vs. catecholamines (norepinephrine and epinephrine). We aimed to
Denise C. Hasson, MD, Katja M. Gist, DO, MSc, JangDong Seo, PhD, Erin K. Stenson, MD, Aaron Kessel, MD, MS, Taiki Haga, MD, MSc, Sara LaFever, MD, PhD, Maria Jose Santiago, MD, PhD, Matthew Barhight, MD, MS, David Selewski, MD, MSCR, Zaccaria Ricci, MD, Nicholas J. Ollberding, PhD, Natalja L. Stanski, MD, on behalf of the Worldwide Exploration of Renal Replacement Outcomes Collaborative in Kidney Disease (WE-ROCK) Collaborative, Emily Ahern, CPNP, DNP, Ayse Akcan Arikan, MD, Issa Alhamoud, MD, Rashid Alobaidi, MD, MSc, Pilar Anton-Martin, MD, PhD, Shanthi S. Balani, MD, Matthew Barhight, MD, MS, Abby Basalely, MD, MS, Amee M. Bigelow, MD, MS, Gabriella Bottari, MD, Andrea Cappoli, MD, Eileen A. Ciccia, MD, Michaela Collins, BA, Denise Colosimo, MD, Gerard Cortina, MD, Mihaela A. Damian, MD, MPH, Sara De la Mata Navazo, MD, Gabrielle DeAbreu, MD, Akash Deep, MD, Kathy L. Ding, BS, Kristin J. Dolan, MD, Sarah N. Fernandez Lafever, MD, PhD, Dana Y. Fuhrman, DO, MS, Ben Gelbart, MBBS, Katja M. Gist, DO, MSc, Stephen M. Gorga, MD, MSc, Francesco Guzzi, MD, Isabella Guzzo, MD, Taiki Haga, MD, Elizabeth Harvey, MD, Denise C. Hasson, MD, Taylor Hill-Horowitz, BS, Haleigh Inthavong, BS, MS, Catherine Joseph, MD, Ahmad Kaddourah, MD, MS, Aadil Kakajiwala, MD, MSCI, Aaron D. Kessel, MD, MS, Sarah Korn, DO, Kelli A. Krallman, BSN, MS, David M. Kwiatkowski, MD, Msc, Jasmine Lee, MSc, Laurance Lequier, MD, Tina Madani Kia, BS, Kenneth E. Mah, MD, MS, Eleonora Marinari, MD, Susan D. Martin, MD, Shina Menon, MD, Tahagod H. Mohamed, MD, Catherine Morgan, MD, MSc, Theresa A. Mottes, APRN, Melissa A. Muff-Luett, MD, Siva Namachivayam, MBBS, Tara M. Neumayr, MD, Jennifer Nhan Md, MS, Abigail O’Rourke, MD, Nicholas J. Ollberding, PhD, Matthew G. Pinto, MD, Dua Qutob, MD, Valeria Raggi, MD, Stephanie Reynaud, MD, Zaccaria Ricci, MD, Zachary A. Rumlow, DO, María J. Santiago Lozano, MD, PhD, Emily See, MBBS, David T. Selewski, MD, MSCR, Carmela Serpe, MSc, PhD, Alyssa Serratore, RN, MsC, Ananya Shah, BS, Weiwen V. Shih, MD, H. Stella Shin, MD, Cara L. Slagle, MD, Sonia Solomon, DO, Danielle E. Soranno, MD, Rachana Srivastava, MD, Natalja L. Stanski, MD, Michelle C. Starr, MD, MPH, Erin K. Stenson, MD, Amy E. Strong, MD, MSCE, Susan A. Taylor, MSc, Sameer V. Thadani, MD, Amanda M. Uber, DO, Brynna Van Wyk, ARNP, MSN, Tennille N. Webb, MD, MSPH, Huaiyu Zang, PhD, Emily E. Zangla, DO, Michael Zappitelli, MD, MSc, T. Christine, E. Alvarez, MHI, RN, Elizabeth Bixler, BS, Erica Blender Brown, MA, CRA, Cheryl L. Brown, BS, Ambra Burrell, BA, Anwesh Dash, BS, Jennifer L. Ehrlich, RN, MHA, Simrandeep Farma, HBSc, Kim Gahring, RN, BSN, CCRN, Barbara Gales, RN, Madison R. Hilgenkamp, Sonal Jain, MS, Kate Kanwar, BA, MS, Jennifer Lusk, BSN, RN, CCRN, Christopher J. Meyer, BA AA, Katherine Plomaritas, BSN, RN, Joshua Porter, BS, Jessica Potts, BSN, RN, Alyssa Serratore, BNurs, GDipNP(PIC), RN, MsC, Elizabeth Schneider, BS, Vidushi Sinha, BS, P. J. Strack, RN, BSN, CCRN, Sue Taylor, RN, Katherine Twombley, MD, Brynna Van Wyk, MSN, ARNP, CPNP, Samantha Wallace, MS, Janet Wang, BS, Megan Woods, BS, Marcia Zinger, RN, Alison Zong, BS   +130 more
doaj   +1 more source

Retinoic Acid Signalling Regulates Zebrafish Tooth Germ Repair Following Injury

Cell Proliferation, EarlyView.
Retinoic acid signalling may regulate the repair processes in a tooth germ injury model using Tg(scpp5:Dendra2‐NTR) zebrafish and the nitroreductase (NTR)/metronidazole (MTZ) system. ABSTRACT Although the role of retinoic acid (RA) signalling in odontogenesis is well established, its involvement in the repair of injured tooth germs remains unclear.
Qiqi Liu, Zhenan Zhang, Weifeng Hao, Chunyan Zhou, Deqin Yang   +4 more
wiley   +1 more source

Intravenous Oxytocin Has no Effect on Ad Libitum Food Intake or Postprandial Plasma Glucose Concentrations in Individuals With Obesity: A Randomised, Placebo‐Controlled, Double‐Blind, Crossover Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Introduction Oxytocin is expressed throughout the small intestine, suggesting a role for oxytocin in postprandial metabolism. Accordingly, single‐dose intranasal oxytocin reduces food intake and improves glucose tolerance. We investigated the effects of a continuous intravenous oxytocin infusion on ad libitum food intake, appetite sensations ...
Ida M. Gether, Vivian Kliim‐Hansen, Petur T. Olafsson, Miriam G. Pedersen, Casper K. Nielsen, Anne‐Marie Ellegaard, Mikkel B. Christensen, Jens F. Rehfeld, Jørn W. Helge, Jens J. Holst, Bolette Hartmann, Filip K. Knop, Lærke S. Gasbjerg, Asger B. Lund   +13 more
wiley   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

The Development and Validation of the Partial Denture Experience Questionnaire (P‐DEQ): Reliability and Validity

Gerodontology, EarlyView.
ABSTRACT Introduction This paper describes the development and preliminary validation of the Partial Denture Experience Questionnaire (P‐DEQ), a new, condition‐specific instrument designed to measure the multifaceted impacts of living with removable dentures. Methods The P‐DEQ was developed using a multi‐phase, mixed‐methods design. Item generation was
Barry J. Gibson, Nicolas Martin, Bilal El‐Dhuwaib, Gerry McKenna, Sandra Clifford, Alastair Lomax, Sarah R. Baker   +6 more
wiley   +1 more source