Results 51 to 60 of about 2,624 (282)

Analytical methods for the quantitative determination of oxytocin [PDF]

, 2010
Oxytocin is a clinically important nonapeptide that is used for the induction and/or augmentation of labor and is normally administered as a slow intravenous infusion diluted with normal saline or Ringer’s lactate solution. Oxytocin is also indicated for
Chaibva, F A, Walker, Roderick
core   +1 more source

Cellular Snowballing: Cell Adhesion and Migration Drive the Self‐Assembly of Cell‐Microgel Biohybrid Spheroids

Advanced Science, EarlyView.
A new class of biohybrid spheroids is engineered through the self‐assembly of adherent cells and extracellular matrix‐mimetic hydrogel microparticles (microgels). By mimicking a snowballing effect, this approach enables scalable formation of porous, millimeter‐scale spheroids with enhanced cell viability and molecular diffusion.
Zaman Ataie, Sina Kheirabadi, Changhao Li, Aneesh Risbud, Aswathy Sebastian, Istvan Albert, Sulin Zhang, Amir Sheikhi   +7 more
wiley   +1 more source

In vitro binding and receptor-mediated activity of terlipressin at vasopressin receptors V1 and V2

Journal of Experimental Pharmacology, 2017
Khurram Jamil,1 Stephen Chris Pappas,2 Krishna R Devarakonda1 1Clinical Development, Mallinckrodt Pharmaceuticals, Bedminster, 2Orphan Therapeutics, LLC, Lebanon, NJ, USA Abstract: Terlipressin, a synthetic, systemic vasoconstrictor with selective ...
Jamil K, Pappas SC, Devarakonda KR
doaj  

Caesarean myomectomy in a tertiary health facility in southern Nigeria: Report of a series of successful cases

Ibom Medical Journal
Uterine leiomyoma is the commonest tumour of the uterus with incidence of about 20-40% in reproductive age women. Treatment of leiomyoma during caesarean section remains a controversial subject in spite of advancement in medical treatment.
Eyong EM, Okpebri KO, Omoronyia EE, Emechebe CI, Ekabua JE   +4 more
doaj   +1 more source

Blutflußveränderungen in den kleinen Beckenarterien im Verlaufe physiologischer Spontanzyklen bei Frauen unterschiedlichen Alters - Untersuchung mittels transvaginaler Farbdopplersonographie [PDF]

, 2004
Das Ziel dieser Arbeit war es, im Rahmen eines explorativen Studiendesigns Durchblutungsverläufe mittels des Messparameters vmean (mittlere Blutflussgeschwindigkeit) durch transvaginale dopplersonographische Messungen in den Arteriae uteri-nae, Arteriae ...
Dörffel, Susanne, Prof. Dr. med. U. Deichert   +1 more
core   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

ELECTROENCEPHALOGRAPHIC AND BEHAVIORAL AROUSAL EFFECTS OF SMALL DOSES OF NICOTINE: A NEUROPSYCHOPHARMACOLOGICAL STUDY * [PDF]

, 1967
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75488/1/j.1749-6632.1967.tb13726.x ...
Domino, Edward F.
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Assoziation der vasoaktiven Prohormone Copeptin, MR-proADM und MR-proANP mit dem Metabolischen Syndrom, dem Typ 2 Diabetes und vorzeitiger Atherosklerose [PDF]

, 2017
Der Diabetes mellitus Typ 2 ist eine multifaktorielle Erkrankung mit hoher und weiter zunehmender Prävalenz. Um effektive Präventionsstrategien entwickeln zu können, ist ein besseres Verständnis der dem Diabetes vorausgehenden pathophysiologischen ...
Then, Cornelia
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